Investigating Contamination Issues - Thermo Scientific ISQ 7000 Hardware Manual

Investigating Contamination Issues

Thermo Scientific
Some chemical noise is common and difficult to eliminate completely.
Chemical noise is sometimes caused by:
• A septum bleed after a series of injections.
• A vial septum bleed, which occurs if more than one injection is made from a sample vial.
• Siloxane peaks that appear in the chromatogram at regular intervals from focusing at the
head of the column or in the injector.
Other possible contamination sources include hydrocarbon contamination of the carrier gas,
foreline pump, or cleaning solvents.
To minimize chemical noise, always wear clean, lint- and powder-free gloves when performing
maintenance on components that go inside the vacuum chamber and always use clean carrier
gas, filters, and liners.
IMPORTANT Many nitrile and latex gloves not certified for clean room use contain
silicone mold releasing agents that will contaminate the instrument. For this reason, clean
room gloves are strongly recommended when handling the ion source cartridge. We
recommend Cardinal Health CP100 Nitrile Cleanroom Gloves. See the ISQ 7000 Spare
Parts Guide for ordering information.
WARNING ELECTRICAL SHOCK HAZARD: When troubleshooting any issue that requires
removing a cover on the ISQ 7000 mass spectrometer, you should power-off and vent the
instrument to avoid harming yourself.
AVERTISSEMENT RISQUE D'ÉLECTROCUTION : lorsque vous cherchez à résoudre un
problème nécessitant d'enlever le couvercle du spectromètre de masse ISQ 7000, mettez
hors tension et ventilez l'instrument pour éviter de vous blesser.
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Troubleshooting
Investigating Contamination Issues
ISQ 7000 Hardware Manual 125