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Adverse
Effects
07-19-01-518 – January 2009
A
C
LYX
OMPONENT
Adverse effects that donors may experience during blood
separation and collection are similar to those sometimes
experienced during routine blood collection and apheresis.
Those similar to blood collection include:
• Light-headedness
• Fainting
• Vomiting
• Hyperventilation
• Hematoma formation at the site of venipuncture
• Syncopal reactions due to hypovolemia
Reactions that are unique to apheresis collection procedures
include:
• Allergic symptoms such as skin redness, itching, and hives
• Chills (induced by infusion of room temperature saline or
donor blood)
• Moderate hypocalcemia due to chelation of calcium by
unmetabolized citrate (caused by infusion of anticoagulants
containing citrate). This reaction is usually manifested by:
• Unusual taste or smell
• Tingling around the mouth or fingers
• Muscle discomfort, muscle twitching, or spasms
• Symptoms of severe hypocalcemia although rare include:
• Tetany
• Convulsions
• Cardiac arrythmias
Improper operating conditions may cause complications such as
blood loss, hemolysis, air embolism, and blood clotting.
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