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Glossary
a (alpha) The peak of the measured signal in a
time-resolved fluorescence measurement.
Abs See absorbance (optical density).
absorbance (optical density) (Abs) A logarithmic
function of the transmission of a wavelength of
light through a liquid.
log (I/I
), dimension [A]
0
bioluminescence Naturally occurring
chemiluminescence from light-emitting
organisms, e.g., glowworms, some deep-sea fish,
some bacteria and some fungi.
biometrics A method of verifying an individual's
identity based on a measurement of the
individual's physical feature(s) or repeatable
actions where those features and/or actions are
both unique to that individual and measurable.
chemiluminescence Luminescence as a result of
pure chemical reactions.
CFR See FDA Code of Federal Regulations.
closed system An environment in which system
access is controlled by persons who are
responsible for the content of electronic records
that are in the system.
COM port Serial RS-232 port.
computer system validation Confirmation by
examination and provision of objective evidence
that computer system specifications conform to
user needs and intended uses, and that all
requirements can be consistently fulfilled.
crossover point The point where the excitation and
emission spectra meet.
crosstalk Interfering signal from neighboring wells.
DDE See Drug Discovery Edition.
Thermo Fisher Scientific
Drug Discovery Edition (DDE) Drug Discovery
Edition of SkanIt Software. The DDE includes
features needed for compliance with FDA's
21CFR11.
See Also FDA Code of Federal Regulations.
decade Order of magnitude. A logarithmic value
that is used for presentation of dynamic range.
diffraction Spreading of light transmitted through
a narrow slit or reflected from a narrow groove.
digital signature An electronic signature based on
cryptographic methods of originator
authentication, computed by using a set of rules
and a set of parameters such that the identity of
the signer and the integrity of the data can be
verified.
dose-effect curve This is a graph drawn to show the
relationship between the dose of a drug or other
chemical and the magnitude of the graded effect
that it produces.
dynamic range Dynamic range refers to the range
of signals an instrument can read, from the
minimum to the maximum detectable. For
example, dynamic range of seven decades means
that the difference between the lowest and highest
signals that can be measured is 10
electronic record Any combination of text,
graphics, data, audio, pictorial, or other
information representation in digital form that
is created, modified, maintained, archived,
retrieved, or distributed by a computer system.
electronic signature A computer data compilation
of any symbol or series of symbols executed,
adopted, or authorized by an individual to be the
legally binding equivalent of the individual's
handwritten signature.
emission The release of light from a fluorochrome
when an electron falls from an excited state to a
lower energy state of the molecule.
EMU Emulation mode.
®
Thermo Scientific SkanIt
Software for Varioskan
7
.
®
User Manual
303
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