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Thermo Scientific Manuals
Laboratory Equipment
LTQ Series
Hardware manual
Thermo Scientific LTQ Series Hardware Manual
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Contents
Table of Contents
Bookmarks
Table of Contents
Table of Contents
Preface
Related Documentation
Getting a Trap-HCD License
Getting a New License Code
Installing a New License Code
Safety and Special Notices
Contacting Us
Chapter 1 Introduction
LTQ Series Mass Spectrometers
Overview of an LC/MS Analysis
Chapter 2 Functional Description
Overview
Figure 1. Functional Block Diagram of an LTQ Series System
Syringe Pump
Figure 2. Syringe Pump
Figure 3. Syringe Pump On/Off Button
Divert/Inject Valve
Leds and Button
Figure 4. Divert/Inject Valve Button and Leds
Divert Valve Positions
Injection Valve Operation
Figure 5. Divert Valve Positions
Mass Spectrometer
Figure 6. Inject Valve Positions
Figure 7. LTQ Series Front Panel Leds
Leds
Figure 8. Power Panel for the LXQ
Figure 9. Power Panel for the LTQ XL and Velos Pro
Power Panel
API Source
Ion Source Interface
Figure 10. LXQ Ion Source Interface (Cross Section)
Figure 11. LTQ XL Ion Source Interface (Cross Section)
Figure 12. Skimmer and Tube Lens (Back View)
Figure 13. Velos Pro Ion Source Interface (Cross Section)
Figure 14. Velos Pro Exit Lens and S-Lens (Back View)
Figure 15. MP00 Rf Lens (LTQ XL on the Left and Velos Pro on the Right)
Ion Optics
Figure 16. MP0 for the LXQ and LTQ XL
Figure 17. MP0 for the LTQ Velos
Figure 18. MP0 with a Beam Stop Post for the Velos Pro
Figure 19. MP1 Ion Optics
Figure 20. LTQ XL Linear Ion Trap Rod Assembly
Mass Analyzer
Figure 21. Visual Representation of Mass Analyzer Operation
Ion Detection Systems
Vacuum System
Figure 22. Functional Block Diagram of the Vacuum System
Figure 23. LXQ Vacuum Manifold with Top Cover Plate and Turbomolecular Pump
Figure 24. Turbomolecular Pump
Inlet Gases Hardware
Cooling Fans
Chapter 3 System Shutdown, Startup, and Reset
Shutting down the System in an Emergency
Opening the Tune Plus Window
Figure 25. Tune Plus Window for Velos Pro
Placing the Mass Spectrometer in Standby Mode
Turning on the Mass Spectrometer
Shutting down the Mass Spectrometer Completely
Starting the System after a Complete Shutdown
Starting the LC System
Starting the Data System
Starting the Mass Spectrometer
Starting the Autosampler
Resetting the Mass Spectrometer
Resetting Tune and Calibration Parameters
Restarting the Data System
Turning off Selected Mass Spectrometer Components
Chapter 4 Daily Operation
Before Operating the LTQ Series System
Checking the System Mode
Checking the Vacuum Pressure Levels
Figure 26. Vacuum Dialog Box
Checking the Gas Supplies
Checking the ESI Fused-Silica Sample Tube for Elongation
After Operating the LTQ Series System
Flushing the Sample Transfer Line, Sample Tube, and API Probe
Figure 27. APCI Source Dialog Box
Figure 28. ESI Source Dialog Box
Cleaning the Ion Sweep Cone, Spray Cone, and Ion Transfer Tube
Purging the Oil in the Forepump
Emptying the Solvent Waste Container
Placing the System in Standby Mode
Chapter 5 Maintenance
Tools and Supplies
Ion Source Probe Maintenance
ESI Probe Maintenance
Figure 29. Two-Piece Fingertight Fitting and Loosened Sample Inlet Adapter Fitting
Figure 30. ESI Probe with the Nozzle Removed
Figure 31. ESI Nozzle and O-Ring
Figure 32. Front End of the ESI Probe (Exploded View)
Figure 33. Fused-Silica Sample Tube Inserted through the Front of the ESI Probe
Figure 34. Natural PEEK Safety Sleeve Installed in the Sample Inlet (ESI Probe)
Figure 35. Natural PEEK Adaptor Fitting Installed to Secure the Safety Sleeve
Figure 36. Fingertight Fittings Installed over the Safety Sleeve (ESI Probe)
Figure 37. Grounding Union Positioned in the Grounding Bar
Figure 38. Safety Sleeve Connection to the Grounding Union (ESI Probe)
Figure 39. Sample Tube Securely Tightened to the Grounding Union (ESI Probe)
Figure 40. Adjusting the Sample Tube Position (ESI Probe)
Figure 41. Sample Tube Position for Flow Rates Greater than 100 Μl/Min (ESI Probe)
HESI-II Probe Maintenance
Figure 42. Components of the Metal ESI Needle Insert
Figure 43. Tip (Enlarged) of the Metal ESI Needle Insert
Figure 44. HESI-II Probe Disassembled (Exploded View)
Figure 45. HESI-II Probe Nozzle Tip (Enlarged)
APCI Probe Maintenance
Figure 46. APCI Probe
Figure 47. APCI Probe (Cross Section)
Figure 48. Sample Inlet End of the APCI Probe Showing Locked and Unlocked
Figure 49. APCI Probe Nozzle Assembly
Figure 50. 3/8 In. Open-End Wrench on the APCI Flange Fitting
Figure 51. APCI Sample Tube Connection
Figure 52. Sample Tubing Connection to the APCI Flange Fitting
Figure 53. Sample Tube Extending Past the APCI Nozzle Tip
Ion Source Interface Maintenance
Removing the Ion Source Interface
Cleaning the Skimmer and Tube Lens on the LXQ and LTQ XL Mass Spectrometers
Figure 54. Ion Source Interface Removed from the Vacuum Manifold
Figure 55. Skimmer, Tube Lens, and Ion Source Interface Cage for the LXQ and
Cleaning the Exit Lens and S-Lens on the Velos Pro
Figure 56. LTQ XL Ion Source Interface Cage
Figure 57. Exit Lens, S-Lens, and Ion Source Interface Cage for the Velos Pro
Cone
Figure 58. Vacuum Dialog Box
Figure 59. Inlet Direct Control Dialog Box for an Accela 1250 Pump
Figure 60. Ion Sweep Cones
Figure 61. Ion Transfer Tube Removal Tool
Figure 62. Ion Source Interface Components for the LXQ and LTQ XL
Figure 63. Ion Source Interface Components for the Velos Pro
Reinstalling the Ion Source Interface
MP00 RF Lens Maintenance
Removing the MP00 RF Lens Assembly
Figure 64. MP00 Rf Lens Assembly Removal
Disassembling the MP00 RF Lens Assembly
Figure 65. MP00 and Lens L0 Wiring Connections (LTQ XL)
Cleaning the MP00 RF Lens Assembly Components
Figure 66. MP00 Rf Lens Assembly (LTQ XL)
Reassembling the MP00 RF Lens Assembly
Reinstalling the MP00 RF Lens Assembly
MP0 and MP1 Ion Guides Maintenance
Removing the Top Cover of the Mass Spectrometer
Figure 67. Front Door Latch
Figure 68. Top Cover Screws
Figure 69. Top Cover Pushed Back
Removing the Vacuum Manifold's Top Cover Plate
Figure 70. Electrical Connections to the Top Cover Plate of the Vacuum Manifold
Removing the MP0 and MP1 Ion Guides
Figure 71. MP0 and MP1 Ion Guides for the LXQ (Exploded View)
Figure 72. MP0 and MP1 Ion Guides for the LTQ XL (Exploded View)
Figure 73. MP0 and MP1 Ion Guides for the LTQ Velos (Exploded View)
Figure 74. MP0 and MP1 Ion Guides for the Velos Pro (Exploded View)
Gate Lens
Reinstalling the MP0 and MP1 Ion Guides
Figure 75. LXQ Wiring Diagram for the MP0 and MP1 Ion Guides
Figure 76. LTQ XL Wiring Diagram for the MP0 and MP1 Ion Guides
Figure 77. Velos Pro Wiring Diagram for the MP0 and MP1 Ion Guides
Reinstalling the Vacuum Manifold's Top Cover
Reinstalling the Top Cover of the Mass Spectrometer
Electron Multiplier Replacement
Figure 78. Electron Multipliers and Dual Anode (LTQ XL)
Figure 79. Electron Multipliers and Shield Retainers (Velos Pro)
Figure 80. Placement of Screws for the Left and Right Electron Multipliers (Top View)
Figure 81. Placement of the Electron Multipliers and Shield Retainers on the Top
Figure 82. Diagnostics Dialog Box Showing the Set Device List
Figure 83. Diagnostics Dialog Box Showing the Electron Multiplier Voltage Parameters
Figure 84. Diagnostics Dialog Box Showing the Mass Calibration Page
Figure 85. Calibrate Dialog Box Showing the Automatic Page
Figure 86. Semi-Automatic Page in the Calibrate Dialog Box (LXQ and LTQ XL)
Figure 87. Semi-Automatic Page in the Calibrate Dialog Box (Velos Pro)
Forepump Maintenance
Fan Filter Maintenance
Chapter 6 Diagnostics
Running General Diagnostic Tests
Figure 88. Diagnostics Dialog Box Showing the General Test Page
Using the Diagnostic Tools
Running System Evaluation Tools
Figure 89. Diagnostics Dialog Box Showing the System Evaluation Tools Page
System Evaluation Tools
Chapter 7 Replaceable Parts
MS Setup Kit
Accessory Kits
Chemical Kit
Ion Source Probes and Parts
Ion Source Interface Parts
MP00 Lens Parts
MP0 and MP1 Ion Guide Parts
Electron Multipliers
Miscellaneous Parts
Fittings
Forepumps
Vacuum Manifold Parts
Glossary
Index
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Figure 1. Functional Block Diagram of an Ltq Series System
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LTQ Series
Hardware Manual
97055-97072 Revision C
June 2012
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This manual is also suitable for:
Lxq
Ltq xl
Ltq etd
Maldi ltq xl
Ltq velos
Ltq velos/etd
...
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Velos pro
Velos pro/etd
Ltq velos pro
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