Procedure For Zdrive Implantation And Maintenance - TDT RZ2 Manual

Procedure for zDrive Implantation
and Maintenance
Note: The zDrive Microdrives with ZIF-Clip® Arrays were developed in partnership with
Scuola Internazionale Superiore di Studi Avanzati (SISSA).
Acknowledgments:
This document is based on practical experience at the Diamond LAB
SISSA and was written with the help of Diamond lab researchers;
especially Dr. Arash Fassihi Zakeri, Dr. Shima Talehy Moheiddin, Dr.
Nader Nikbakht, Dr. Francesca Pulecchi and Dr. Sergey Antopolskiy
Overview
The main advantage of using the
zDrive Head-Mounted Microdrive
with ZIF-Clip microwire Array is to
extend the recording lifetime with
an electrode array and thereby
facilitate acquiring the maximum
amount of data per surgery. The
care and maintenance of the drive,
as explained in this document, is
necessary to achieve optimal
results.
The implantation procedure
described in this document was
thoroughly tested and yielded the
best results for successful
implantation of the microdrive in a
rat. Before implanting rats with
microwire arrays mounted with a
microdrive, please read the entire
protocol. These guidelines are
intended to:
•
•
•
•
In the steps described below, the microdrive will be implanted in a craniotomy and
cemented into place with ground and reference wire connections. Guidance for
Guarantee correct implantation
Decrease the de-implantation ratio
Ensure good signals for the neural activity recording
Decrease the risk of damage to the microdrive, due to CSF, blood or extra-
cellular fluids (ECF) that can mechanically interfere with operation

Procedure for zDrive Implantation and Maintenance

13-17