Solvent Miscibility - Thermo Scientific Dionex UltiMate 3000 Series Operating Instructions Manual

UltiMate 3000 Series:
NCS-3500RS and NCP-3200RS

12.2 Solvent Miscibility

Miscibility describes the ability of liquids to form homogeneous mixtures in all proportions
(one-phase system). Solvent miscibility is important during elution and when changing
from one solvent to another. Thus, when you prepare solvents consider the miscibility and
homogeneous mixing of the single components. Note that certain compositions of some
solvent systems may result in miscibility gaps.
For information about solvent miscibility, see the table (source: Handbuch der HPLC, GIT
Verlag, 1995). The table provides a general idea of solvent miscibility. Under certain
conditions, non-miscible liquids may mix or miscible liquids may separate.
Name
Acetone
Acetonitrile
Benzene
Butanol
t-Butylmethylether
Cyclohexane
Cyclopentane
Dichloroethane
Dichloromethane
Di-Ethylether
Dimethylformamide
Dimethyl sulfoxide
Dioxane
Di-Propylether
Acetic acid
Ethanol
Ethyl acetate
Heptane
Hexane
Methanol
Methyl ethyl ketone
Octane
Pentane
Propylalcohol
Tetrachloromethane
Tetrahydrofuran
Toluene
1.1.1. Trichlorethane
Trichloromethane
Water
Xylene
Page 250
= miscible
= non-miscible
Operating Instructions