Intellistart Fluidics System - Waters Xevo G2-XS QTof Overview And Maintenance Manual

1 Waters Xevo G2-XS QTof Overview

IntelliStart Fluidics system

The IntelliStart Fluidics system is built into the instrument and controls how
the system delivers sample to the source. System connections differ according
to whether you use a LockSpray, NanoLockSpray, or ionKey source. See
page 223.
For standard flow applications, the system delivers sample directly to the
mass spectrometer's source in one of three ways:
• From the LC column.
• From three integral reservoir bottles. Use standard reservoir bottles
(30 mL) for instrument setup and calibration. Use low-volume vials
(1.5 mL) to infuse smaller volumes.
The reservoir bottles can also deliver sample through direct or combined
infusion, permitting optimization at analytical flow rates.
• From a wash reservoir that contains solvent for automated flushing of
the instrument's solvent delivery system.
For ACQUITY UPLC M-Class, the valves and pumps of the IntelliStart
Fluidics system introduce dead volume, which can cause unacceptable peak
broadening. For this reason, the ACQUITY UPLC M-Class is plumbed directly
to the NanoFlow sprayer using a suitable, short piece of silica tubing.
For reference flows for the LockSpray, NanoLockSpray, or ionKey sources, the
IntelliStart Fluidics system delivers lock-mass solution from reservoir bottle
B or, for extended operating hours, from a separate, external bottle of
lock-mass solution.
38 April 2, 2015, 715004496 Rev. B