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1.2
Electrospray ionization (ESI)
In electrospray ionization (ESI), a strong electrical charge is applied to the eluent as it emerges
from a nebulizer. The droplets that compose the resultant aerosol undergo a reduction in size
(solvent evaporation). As solvent continues to evaporate, the charge density increases until the
droplet surfaces eject ions (ion evaporation). The ions can be singly or multiply charged.
The standard ESI probe accommodates eluent flow rates as high as 2 mL/min, making it suitable
for LC applications in the range 100 µL/min to 2 mL/min.
See
page 37
for further details.
1.3
IntelliStart fluidics system
1.3.1
Functionality
The IntelliStart fluidics system is a solvent delivery system built into the mass spectrometer. It
delivers sample or solvent directly to the MS probe in one of three ways:
•
From the LC column (ACQUITY UPLC IVD or ACQUITY UPLC I-Class IVD).
•
From two integral reservoirs. (See
•
From a wash reservoir that contains solvent for automated flushing of the instrument's
solvent delivery system.
The onboard system incorporates a selector valve, an infusion pump, and two sample reservoirs
mounted on the bottom, right-hand side of the instrument.
Recommendation:
reservoir B for analyte or optimization solution.
page 33
Use reservoir A for the calibrant solution and for tuning compounds, and
September 7, 2016, 715003560IVD Rev. C
Page 21
for details.)
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