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Xevo TQ MS
Waters Xevo TQ MS Manuals
Manuals and User Guides for Waters Xevo TQ MS. We have
3
Waters Xevo TQ MS manuals available for free PDF download: Operator's, Overview And Maintenance Manual, Operator And Maintenance Manual, Quick Start Manual
Waters Xevo TQ MS Operator's, Overview And Maintenance Manual (248 pages)
Brand:
Waters
| Category:
Laboratory Equipment
| Size: 1.9 MB
Table of Contents
General Information
3
Trademarks
3
Customer Comments
4
Safety Considerations
5
Considerations Specific to the Xevo TQ MS
5
FCC Radiation Emissions Notice
8
Canada Spectrum Management Emissions Notice
8
Equipment Misuse Notice
8
Safety Advisories
8
Operating this Instrument
9
Applicable Symbols
9
Audience and Purpose
9
Intended Use of the Xevo TQ MS
10
Calibrating
10
Quality-Control
10
ISM Classification
11
ISM Classification: ISM Group 1 Class a
11
EC Authorized Representative
11
Table of Contents
13
1 Waters Xevo TQ MS Overview
21
Waters Xevo TQ MS
22
ACQUITY Xevo TQ MS UPLC/MS Systems
24
Non-ACQUITY Devices for Use with the Xevo TQ MS
25
Software and Data System
26
Ionization Techniques and Source Probes
27
Electrospray Ionization (ESI)
27
Combined Electrospray Ionization and Atmospheric Pressure Chemical Ionization (Esci)
27
Atmospheric Pressure Chemical Ionization (APCI)
27
Dual-Mode APPI/APCI Source
28
Nanoflow ESI Source
28
Intellistart Fluidics System
29
Overview
29
System Components
30
System Operation
30
Ion Optics
31
MS Operating Modes
32
MS/MS Operating Modes
33
Product (Daughter) Ion Mode
34
Precursor (Parent) Ion Mode
34
Multiple Reaction Monitoring Mode
35
Constant Neutral Loss Mode
36
Scanwave Daughter Scan Mode
37
Leak Sensors
38
Vacuum System
38
Rear Panel
39
2 Preparing the Mass Spectrometer for Operation
41
Starting the Mass Spectrometer
42
Verifying the Instrument's State of Readiness
45
Monitoring the Mass Spectrometer Leds
45
Tuning and Calibration Information
45
Running the Mass Spectrometer at High Flow Rates
46
Preparing the Intellistart Fluidics System
47
Installing the Reservoir Bottles
47
Purging the Infusion Pump
48
Rebooting the Mass Spectrometer
49
Leaving the Mass Spectrometer Ready for Operation
50
Emergency Shutdown of the Mass Spectrometer
50
3 Changing the Mode of Operation
51
ESI Mode
52
Installing the ESI Probe
52
Removing the ESI Probe
56
Esci Mode
57
Optimizing the ESI Probe for Esci Operation
57
APCI Mode
57
Installing the APCI Probe
58
Removing the APCI Probe
60
Combined APPI/APCI Source
61
APPI Operation
61
APCI Operation
62
Dual-Mode Operation
63
The Combined APPI/APCI Source Components
64
Installing the Combined APPI/APCI Source Software
66
Removing the APCI Probe and APPI Source Enclosure
68
Nanoflow ESI Source
69
Installing the Nanoflow Source
70
Fitting a Borosilicate Glass Capillary (Nanovial)
73
Positioning the Borosilicate Glass Capillary Tip
77
Restarting a Stalled Borosilicate Glass Capillary Electrospray
77
4 Maintenance Procedures
79
Maintenance Schedule
81
Spare Parts
82
Troubleshooting with Connections INSIGHT
83
Safety and Handling
84
Preparing the Instrument for Working on the Source
85
Removing and Refitting the Source Enclosure
87
Removing the Source Enclosure from the Instrument
87
Fitting the Source Enclosure to the Instrument
89
Installing and Removing the Corona Pin
90
Installing the Corona Pin in the Source
90
Removing the Corona Pin from the Source
93
Operating the Source Isolation Valve
94
Removing O-Rings and Seals
97
Cleaning the Instrument Case
98
Emptying the Nitrogen Exhaust Trap Bottle
98
Inspecting the Varian Roughing Pump Oil Level
101
Adding Oil to the Varian Roughing Pump
102
Replacing the Varian Roughing Pump Oil and Oil Mist Filter
104
Emptying the Roughing Pump Oil
104
Replacing the Oil Mist Filter
106
To Refill the Pump with Oil
108
Cleaning the Source Components
110
Cleaning the Sampling Cone Assembly
111
Removing the Sampling Cone Assembly from the Source
111
Disassembling the Sampling Cone Assembly
113
Cleaning the Sample Cone and Cone Gas Nozzle
115
Assembling the Sampling Cone Assembly
117
Fitting the Sampling Cone Assembly to the Source
118
Cleaning the Extraction Cone
120
Removing the Ion Block Assembly from the Source Assembly
120
Removing the Extraction Cone from the Ion Block
122
Cleaning the Extraction Cone
124
Fitting the Extraction Cone to the Ion Block
126
Fitting the Ion Block Assembly to the Source Assembly
126
Cleaning the Ion Block Assembly
128
Disassembling the Source Ion Block Assembly
128
Cleaning the Ion Block Components
136
Assembling the Source Ion Block Assembly
138
Cleaning the Source Hexapole Assembly
140
Removing the Ion Block Assembly, Ion Block Support, and Hexapole from the Source Assembly
140
Cleaning the Hexapole Assembly
142
Fitting the Hexapole Assembly, PEEK Ion Block Support, and Ion Block Assembly to the Source Assembly
144
Replacing the ESI Probe Tip and Gasket
146
Removing the ESI Probe Tip and Gasket
146
Fitting the ESI Probe Tip and Gasket
149
Replacing the ESI Probe Sample Capillary
150
Removing the Existing Capillary
150
Installing the New Capillary
155
Cleaning the APCI Probe Tip
158
Replacing the APCI Probe Sample Capillary
159
Removing the Existing Capillary
159
Installing the New Capillary
162
Cleaning or Replacing the Corona Pin
165
Replacing the APCI Probe Heater
166
Removing the APCI Probe Heater
166
Fitting the New APCI Probe Heater
169
Replacing the Ion Block Source Heater
170
Replacing the Source Assembly Seals
174
Removing the Probe Adjuster Assembly Probe and Source Enclosure Seals
174
Fitting the New Source Enclosure and Probe Adjuster Assembly Probe Seals
177
Replacing the Air Filter
179
APPI/APCI Source-Changing the UV Lamp Bulb
181
APPI/APCI Source-Cleaning the Lamp Window
184
APPI/APCI Source-Replacing the APPI Lamp Drive Seals
185
Removing the APPI Lamp Drive Assembly Seals
185
Fitting the New APPI Lamp Drive Assembly O-Rings
191
A Safety Advisories
195
Warning Symbols
196
Specific Warnings
197
Caution Advisory
200
Warnings that Apply to All Waters Instruments and Devices
201
Warnings that Address the Replacing of Fuses
206
Electrical and Handling Symbols
208
Electrical Symbols
208
Handling Symbols
209
B Materials of Construction and Compliant Solvents
211
Preventing Contamination
212
Items Exposed to Solvent
212
Solvents Used to Prepare Mobile Phases
213
C External Connections
215
External Wiring and Vacuum Connections
216
Connecting the Varian Oil-Filled Roughing Pump
217
Making the Electrical Connections to the Varian Oil-Filled Roughing Pump
222
Connecting the Edwards Oil-Free Roughing Pump
223
Making the Electrical Connections for the Edwards Oil-Free Roughing Pump
228
Connecting to the Nitrogen Gas Supply
229
Connecting to the Collision Cell Gas Supply
230
Connecting the Nitrogen Exhaust Line
231
Connecting the Liquid Waste Line
234
Connecting the Workstation
236
Connecting Ethernet Cables
237
Input/Output Signal Connectors
237
Making Signal Connections
240
Connecting to the Electricity Source
243
D Plumbing the Intellistart Fluidics System
245
Preventing Contamination
246
Plumbing Schematic
246
Pipe Specifications
247
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Waters Xevo TQ MS Operator And Maintenance Manual (184 pages)
Brand:
Waters
| Category:
Laboratory Equipment
| Size: 1.77 MB
Table of Contents
Copyright Notice
2
Trademarks
2
Contacting Waters
3
Safety Considerations
3
Considerations Specific to the Xevo TQ MS
4
Safety Advisories
6
Operating this Instrument
7
Applicable Symbols
7
Audience and Purpose
7
Intended Use of the Xevo TQ MS
7
Calibrating
8
Quality Control
8
EC Authorized Representative Information
9
Table of Contents
11
1 Waters Xevo TQ MS Overview
18
Waters Xevo TQ MS
18
ACQUITY ® Xevo TQ MS UPLC/MS Systems
19
Non-ACQUITY Devices for Use with the Xevo TQ MS
20
Software and Data System
21
Instrument Console
21
Ionization Techniques and Source Probes
22
Electrospray Ionization (ESI)
22
Intellistart Fluidics System
23
Overview
23
System Components
24
System Operation
24
Ion Optics
25
MS Operating Modes
26
MS/MS Operating Modes
27
Product (Daughter) Ion Mode
28
Precursor (Parent) Ion Mode
29
Multiple Reaction Monitoring Mode
29
Constant Neutral Loss Mode
30
Scanwave Daughter Scan Mode
30
Leak Sensors
31
Vacuum System
31
Rear Panel
32
2 Preparing the Mass Spectrometer for Operation
34
Starting the Mass Spectrometer
34
Verifying the Instrument's State of Readiness
36
Monitoring the Mass Spectrometer Leds
36
Tuning and Calibration Information
36
Running the Mass Spectrometer at High Flow Rates
37
Preparing the Intellistart Fluidics System
37
Installing the Reservoir Bottles
37
Purging the Infusion Pump
39
Rebooting the Mass Spectrometer
40
Leaving the Mass Spectrometer Ready for Operation
41
Emergency Shutdown of the Mass Spectrometer
41
3 Preparing the ESI Source
44
ESI Mode
44
Installing the ESI Probe
44
Removing the ESI Probe
48
4 Maintenance Procedures
49
Maintenance Schedule
51
Spare Parts
52
Troubleshooting with Connections Insight
53
Safety and Handling
54
Preparing the Instrument for Working on the Source
55
Removal and Refitting of the Source Enclosure
56
Removing the Source Enclosure from the Instrument
56
Fitting the Source Enclosure to the Instrument
57
Operating the Source Isolation Valve
59
Removing O-Rings and Seals
62
Cleaning the Instrument Case
63
Emptying the Nitrogen Exhaust Trap Bottle
63
Inspecting the Varian Roughing Pump Oil Level
65
Adding Oil to the Varian Roughing Pump
66
Replacing the Varian Roughing Pump Oil and Oil Mist Filter
68
Emptying the Roughing Pump Oil
68
Replacing the Oil Mist Filter
69
To Refill the Pump with Oil
71
Cleaning the Source Components
73
Cleaning the Sampling Cone Assembly
74
Removing the Sampling Cone Assembly from the Source
74
Disassembling the Sampling Cone Assembly
76
Cleaning the Sample Cone and Cone Gas Nozzle
78
Assembling the Sampling Cone Assembly
80
Fitting the Sampling Cone Assembly to the Source
81
Cleaning the Extraction Cone
83
Removing the Ion Block Assembly from the Source Assembly
83
Removing the Extraction Cone from the Ion Block
85
Cleaning the Extraction Cone
86
Fitting the Extraction Cone to the Ion Block
88
Fitting the Ion Block Assembly to the Source Assembly
89
Cleaning the Ion Block Assembly
90
Disassembling the Source Ion Block Assembly
90
Cleaning the Ion Block Components
97
Assembling the Source Ion Block Assembly
99
Cleaning the Source Hexapole Assembly
101
Removing the Ion Block Assembly, Ion Block Support, and Hexapole from the Source Assembly
101
Cleaning the Hexapole Assembly
103
Fitting the Hexapole Assembly, PEEK Ion Block Support, and Ion Block Assembly to the Source Assembly
105
Replacing the ESI Probe Tip and Gasket
107
Removing the ESI Probe Tip and Gasket
107
Fitting the ESI Probe Tip and Gasket
110
Replacing the ESI Probe Sample Capillary
111
Removing the Existing Capillary
111
Installing the New Capillary
115
Replacing the Ion Block Source Heater
119
Replacing the Source Assembly Seals
123
Removing the Probe Adjuster Assembly Probe and Source Enclosure Seals
123
Fitting the New Source Enclosure and Probe Adjuster Assembly Probe Seals
125
Replacing the Air Filter
127
A Safety Advisories
132
Warning Symbols
132
Task-Specific Hazard Warnings
132
Specific Warnings
133
Caution Symbol
135
Warnings that Apply to All Waters Instruments
136
Electrical and Handling Symbols
141
Electrical Symbols
141
Handling Symbols
142
B Materials of Construction and Compliant Solvents
144
Preventing Contamination
144
Items Exposed to Solvent
144
Solvents Used to Prepare Mobile Phases
145
C External Connections
148
Mass Spectrometer External Wiring and Vacuum Connections
148
Connecting the Varian Oil-Filled Roughing Pump
149
Making the Electrical Connections to the Varian Oil-Filled Roughing Pump
153
Connecting the Edwards Oil-Free Roughing Pump
154
Connecting to the Nitrogen Gas Supply
159
Connecting to the Collision Cell Gas Supply
161
Connecting the Nitrogen Exhaust Line
162
Connecting the Liquid Waste Line
165
Connecting the Workstation
167
Connecting Ethernet Cables
168
Input/Output Signal Connectors
168
Making Signal Connections
171
Connecting to the Electricity Source
174
D Plumbing the Intellistart Fluidics System
176
Preventing Contamination
176
Plumbing Schematic
176
Index
179
Waters Xevo TQ MS Quick Start Manual (2 pages)
No flow from fluidics
Brand:
Waters
| Category:
Laboratory Equipment
| Size: 0.04 MB
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