Waters Xevo TQ-S LC-MS System Manuals

Manuals and User Guides for Waters Xevo TQ-S LC-MS System. We have 3 Waters Xevo TQ-S LC-MS System manuals available for free PDF download: Operator's, Overview And Maintenance Manual, Quick Start Manual

Waters Xevo TQ-S Operator's, Overview And Maintenance Manual (278 pages)

Mass Spectrometry System

Brand: Waters | Category: Laboratory Equipment | Size: 4 MB

General Information
3
Trademarks
3
Contacting Waters
5
Safety Considerations
6
Considerations Specific to the Xevo TQ-S System
6
FCC Radiation Emissions Notice
10
Canada Spectrum Management Emissions Notice
10
Safety Hazard Symbol Notice
10
Equipment Misuse Notice
10
Safety Advisories
10
Operating this Instrument
11
Applicable Symbols
11
Audience and Purpose
13
Intended Use of the Xevo TQ-S
13
Calibrating
13
Quality Control
14
ISM Classification
14
ISM Classification: ISM Group 1 Class a
14
EC Authorized Representative
15
Table of Contents
17
Waters Xevo TQ-S Overview
25
Waters Xevo TQ-S
26
ACQUITY UPLC/MS Xevo TQ-S Systems
28
Non-ACQUITY Devices for Use with the Xevo TQ-S
30
Software and Data System
31
Ionization Techniques and Source Probes
32
Esi
32
Esci
32
Apci
32
Dual-Mode APPI/APCI Source
33
Low-Flow ESI Probe
33
Nanoflow ESI Source
33
Atmospheric Solids Analysis Probe
34
Apgc
34
TRIZAIC UPLC Source
34
Ionkey Source
34
Intellistart Fluidics System
35
Overview
35
System Components
36
System Operation
36
Ion Optics
36
MS Operating Modes
37
MS/MS Operating Modes
38
Product (Daughter) Ion Mode
39
Precursor (Parent) Ion Mode
40
MRM Mode
40
Constant Neutral Loss Mode
41
Scanwave Daughter Scan Mode
42
Leak Sensors
42
Vacuum System
43
Rear Panel
43
Preparing the Mass Spectrometer for Operation
45
Starting the Mass Spectrometer
46
Verifying the Instrument's State of Readiness
48
Monitoring the Mass Spectrometer Leds
48
Tuning and Calibration Information
49
Running the Mass Spectrometer at High Flow Rates
50
Preparing the Intellistart Fluidics System
51
Installing the Reservoir Bottles
51
Adjusting the Solvent Delivery Tube Positions
53
Purging the Infusion Pump
54
Rebooting the Mass Spectrometer
55
Leaving the Mass Spectrometer Ready for Operation
56
Emergency Shutdown of the Mass Spectrometer
56
Changing the Mode of Operation
57
ESI Mode
57
Installing the ESI Probe
58
Removing the ESI Probe
62
Esci Mode
62
Optimizing the ESI Probe for Esci Operation
63
APCI Mode
63
Installing the Ionsabre II Probe
64
Removing the Ionsabre II Probe
67
Combined APPI/APCI Source
67
APPI Operation
67
APCI Operation
68
Dual-Mode Operation
69
The Combined APPI/APCI Source Components
70
Installing the Combined APPI/APCI Source
72
Nanoflow ESI Source
74
Installing the Nanoflow Source
76
Fitting a Borosilicate Glass Capillary (Nanovial)
78
Positioning the Borosilicate Glass Capillary Tip
81
Restarting a Stalled Borosilicate Glass Capillary Electrospray
82
Ionkey Source
82
Installing the Ionkey Source
83
Installing Ionkey Source Software
88
Installing the Camera in the Ionkey Source
89
Removing an Ionkey Source
89
Maintenance Procedures
91
Maintenance Schedule
92
Spare Parts
95
Troubleshooting with Connections INSIGHT
96
Safety and Handling
97
Preparing the Instrument for Working on the Source
98
Removing and Refitting the Source Enclosure
100
Removing the Source Enclosure from the Instrument
100
Fitting the Source Enclosure to the Instrument
102
Installing and Removing the Corona Pin
102
Installing the Corona Pin in the Source
103
Removing the Corona Pin from the Source
105
Operating the Source Isolation Valve
107
Removing O-Rings and Seals
110
Cleaning the Instrument Case
111
Emptying the Nitrogen Exhaust Trap Bottle
111
Maintaining the Oerlikon Leybold Oil-Filled Roughing Pumps
113
Gas Ballasting the Oerlikon Leybold Roughing Pumps
115
Inspecting the Roughing Pump Oil Levels
116
Adding Oil to a Roughing Pump
116
Replacing the Roughing Pumps' Oil and Oil Demister Elements
119
Gas Ballasting the Edwards Xds35I Oil-Free Roughing Pump
127
Cleaning the Source Components
128
Cleaning the Sampling Cone Assembly
129
Removing the Sampling Cone Assembly from the Source
129
Disassembling the Sampling Cone Assembly
131
Cleaning the Sample Cone and Cone Gas Nozzle
134
Assembling the Sampling Cone Assembly
136
Fitting the Sampling Cone Assembly to the Source
137
Cleaning the Ion Block Assembly
139
Removing the Ion Block Assembly from the Source Assembly
139
Disassembling the Source Ion Block Assembly
141
Cleaning the Ion Block Components
147
Assembling the Source Ion Block Assembly
149
Fitting the Ion Block Assembly to the Source Assembly
150
Cleaning the Stepwave Ion Guide Assembly
152
Handling the Stepwave Ion Guide Assembly
152
Removing the Ion Block Support from the Source Assembly
152
Removing the Stepwave Assembly from the Source Assembly
154
Disassembling the Stepwave Ion Guide Assembly
158
Cleaning the Stepwave Ion Guide Assembly
161
Assembling the Stepwave Ion Guide Assembly
165
Fitting the Stepwave Assembly to the Source Assembly
167
Fitting the Ion Block Support to the Source
170
Replacing the ESI Probe Tip and Gasket
171
Removing the ESI Probe Tip and Gasket
171
Fitting the ESI Probe Tip and Gasket
174
Replacing the ESI Probe Sample Capillary
175
Removing the Existing Capillary
175
Installing the New Capillary
180
Cleaning the Ionsabre II Probe Tip
183
Replacing the Ionsabre II Probe Sample Capillary
184
Removing the Existing Capillary
184
Installing the New Capillary
187
Cleaning or Replacing the Corona Pin
190
Replacing the Ionsabre II Probe Heater
191
Removing the Ionsabre II Probe Heater
191
Fitting the New Ionsabre II Probe Heater
193
Replacing the Ion Block Source Heater
195
Replacing the Source Assembly Seals
199
Removing the Probe Adjuster Assembly Probe and Source Enclosure Seals
199
Fitting the New Source Enclosure and Probe Adjuster Assembly Probe Seals
201
Replacing the Air Filter
203
APPI/APCI Source-Changing the UV Lamp Bulb
205
APPI/APCI Source-Cleaning the Lamp Window
207
APPI/APCI Source-Replacing the APPI Lamp Drive Seals
208
Removing the APPI Lamp Drive Assembly Seals
208
Fitting the New APPI Lamp Drive Assembly O-Rings
213
Replacing the Ionkey Source Fluid Lines
216
Removing a Fluid Line
217
Installing a Fluid Line
219
Cleaning the Ionkey Source and Connectors
220
A Safety Advisories
223
Warning Symbols
224
Specific Warnings
225
Caution Advisory
228
Warnings that Apply to All Waters Instruments and Devices
229
Warnings that Address the Replacing of Fuses
234
Electrical and Handling Symbols
236
Electrical Symbols
236
Handling Symbols
237
B External Connections
239
External Wiring and Vacuum Connections
240
Connecting the Oerlikon Leybold Oil-Filled Roughing Pumps
241
Connecting the Edwards Oil-Free Roughing Pumps
248
Making the Roughing Pump Connections to the Xevo TQ-S
254
Connecting to the Nitrogen Supply
255
Connecting to the Collision Cell Gas Supply
256
Connecting the Nitrogen Exhaust Line
257
Connecting the Liquid Waste Line
260
Connecting the Workstation
262
Connecting Ethernet Cables for an LC/MS System
263
Input/Output Signal Connectors
263
Making Signal Connections
266
Connecting to the Electricity Source
269
C Materials of Construction and Compatible Solvents
271
Preventing Contamination
272
Items Exposed to Solvent
272
Solvents Used to Prepare Mobile Phases
273
D Plumbing the Intellistart Fluidics System
275
Preventing Contamination
275
Plumbing Schematic
276
Ionkey and Trizaic Source Plumbing
277
Tubing Specifications
278

Waters Xevo TQ-S Operator's, Overview And Maintenance Manual (256 pages)

Mass spectrometry system

Brand: Waters | Category: Laboratory Equipment | Size: 2 MB

Copyright Notice

2
Trademarks

2
Customer Comments

3
Safety Considerations

4
- Considerations Specific to the Xevo TQ-S System
  4
- Safety Advisories
  6
Operating this Instrument

7
- Applicable Symbols
  7
- Audience and Purpose
  7
- Intended Use of the Xevo TQ-S
  7
- Calibrating
  8
ISM Classification

9
- ISM Classification: ISM Group 1 Class a
  9
EC Authorized Representative

9
- Table of Contents
  11
1 Waters Xevo TQ-S Overview

20
- Waters Xevo TQ-S
  
  20
- Ionization Techniques and Source Probes
  
  25
- Intellistart Fluidics System
  
  28
  - Overview
    28
  - System Components
    29
  - System Operation
    29
- Ion Optics
  
  30
- MS Operating Modes
  
  31
- MS/MS Operating Modes
  
  32
- Leak Sensors
  
  36
- Vacuum System
  
  36
- Rear Panel
  
  37
2 Preparing the Mass Spectrometer for Operation

40
3 Changing the Mode of Operation

50
4 Maintenance Procedures

75
A Safety Advisories

198
- Warning Symbols
  
  198
  - Task-Specific Hazard Warnings
    198
  - Specific Warnings
    199
- Caution Symbol
  
  201
- Warnings that Apply to All Waters Instruments
  
  202
- Electrical and Handling Symbols
  
  207
  - Electrical Symbols
    207
  - Handling Symbols
    208
B External Connections

210
- Mass Spectrometer External Wiring and Vacuum Connections
  
  210
- Connecting the Oerlikon Leybold Oil-Filled Roughing Pumps
  
  211
  - Making Tubing Connections
    212
- Connecting the Edwards Oil-Free Roughing Pumps
  
  218
- Making the Roughing Pump Connections to the Xevo TQ-S
  
  224
- Connecting to the Nitrogen Supply
  
  225
- Connecting to the Collision Cell Gas Supply
  
  226
- Connecting the Nitrogen Exhaust Line
  
  227
- Connecting the Liquid Waste Line
  
  230
- Connecting the Workstation
  
  232
- Connecting Ethernet Cables
  
  233
- Input/Output Signal Connectors
  
  233
  - Making Signal Connections
    236
- Connecting to the Electricity Source
  
  239
C Materials of Construction and Compatible Solvents

242
- Preventing Contamination
  
  242
- Items Exposed to Solvent
  
  242
- Solvents Used to Prepare Mobile Phases
  
  243
D Plumbing the Intellistart Fluidics System

246
- Preventing Contamination
  
  246
- Plumbing Schematic
  
  246
Index

249

Waters Xevo TQ-S Quick Start Manual (2 pages)

No flow from fluidics

Brand: Waters | Category: Laboratory Equipment | Size: 0 MB

Symptoms
1
Environment
1
Cause
2
FIX or WORKAROUND
2
Additional Information
2

Waters Categories

Laboratory Equipment Security Sensors Measuring Instruments Control Unit Water Pump

More Waters Manuals

Waters Xevo TQ-S LC-MS System Manuals

Waters Xevo TQ-S Operator's, Overview And Maintenance Manual (278 pages)

Table of Contents

Waters Xevo TQ-S Operator's, Overview And Maintenance Manual (256 pages)

Table of Contents

Copyright Notice

Trademarks

Customer Comments

Safety Considerations

Operating this Instrument

ISM Classification

EC Authorized Representative

1 Waters Xevo TQ-S Overview

Waters Xevo TQ-S

Ionization Techniques and Source Probes

Intellistart Fluidics System

Ion Optics

MS Operating Modes

MS/MS Operating Modes

Leak Sensors

Vacuum System

Rear Panel

2 Preparing the Mass Spectrometer for Operation

Starting the Mass Spectrometer

Preparing the Intellistart Fluidics System

Rebooting the Mass Spectrometer

Leaving the Mass Spectrometer Ready for Operation

Emergency Shutdown of the Mass Spectrometer

3 Changing the Mode of Operation

ESI Mode

Esci Mode

APCI Mode

Combined APPI/APCI Source

Nanoflow ESI Source

4 Maintenance Procedures

Maintenance Schedule

Spare Parts

Troubleshooting with Connections INSIGHT

Safety and Handling

Preparing the Instrument for Working on the Source

Removal and Refitting of the Source Enclosure

Installing and Removing the Corona Pin

Operating the Source Isolation Valve

Removing O-Rings and Seals

Cleaning the Instrument Case

Emptying the Nitrogen Exhaust Trap Bottle

Maintaining the Oerlikon Leybold Oil-Filled Roughing Pumps

Gas Ballasting the Edwards Xds46I Oil-Free Roughing Pump

Cleaning the Source Components

Cleaning the Sampling Cone Assembly

Cleaning the Ion Block Assembly

Cleaning the Stepwave Ion Guide Assembly

Replacing the ESI Probe Tip and Gasket

Replacing the ESI Probe Sample Capillary

Cleaning the Ionsabre II Probe Tip

Replacing the Ionsabre II Probe Sample Capillary

Cleaning or Replacing the Corona Pin

Replacing the Ionsabre II Probe Heater

Replacing the Ion Block Source Heater

Replacing the Source Assembly Seals

Replacing the Air Filter

APPI/APCI Source-Changing the UV Lamp Bulb

APPI/APCI Source-Cleaning the Lamp Window

APPI/APCI Source-Replacing the APPI Lamp Drive Seals

A Safety Advisories

Warning Symbols

Caution Symbol

Warnings that Apply to All Waters Instruments

Electrical and Handling Symbols

B External Connections

Mass Spectrometer External Wiring and Vacuum Connections

Connecting the Oerlikon Leybold Oil-Filled Roughing Pumps

Connecting the Edwards Oil-Free Roughing Pumps

Making the Roughing Pump Connections to the Xevo TQ-S

Connecting to the Nitrogen Supply

Connecting to the Collision Cell Gas Supply

Connecting the Nitrogen Exhaust Line

Connecting the Liquid Waste Line

Connecting the Workstation

Connecting Ethernet Cables