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Xevo TQ-S
Waters Xevo TQ-S LC-MS System Manuals
Manuals and User Guides for Waters Xevo TQ-S LC-MS System. We have
3
Waters Xevo TQ-S LC-MS System manuals available for free PDF download: Operator's, Overview And Maintenance Manual, Quick Start Manual
Waters Xevo TQ-S Operator's, Overview And Maintenance Manual (278 pages)
Mass Spectrometry System
Brand:
Waters
| Category:
Laboratory Equipment
| Size: 4 MB
Table of Contents
General Information
3
Trademarks
3
Contacting Waters
5
Safety Considerations
6
Considerations Specific to the Xevo TQ-S System
6
FCC Radiation Emissions Notice
10
Canada Spectrum Management Emissions Notice
10
Safety Hazard Symbol Notice
10
Equipment Misuse Notice
10
Safety Advisories
10
Operating this Instrument
11
Applicable Symbols
11
Audience and Purpose
13
Intended Use of the Xevo TQ-S
13
Calibrating
13
Quality Control
14
ISM Classification
14
ISM Classification: ISM Group 1 Class a
14
EC Authorized Representative
15
Table of Contents
17
Waters Xevo TQ-S Overview
25
Waters Xevo TQ-S
26
ACQUITY UPLC/MS Xevo TQ-S Systems
28
Non-ACQUITY Devices for Use with the Xevo TQ-S
30
Software and Data System
31
Ionization Techniques and Source Probes
32
Esi
32
Esci
32
Apci
32
Dual-Mode APPI/APCI Source
33
Low-Flow ESI Probe
33
Nanoflow ESI Source
33
Atmospheric Solids Analysis Probe
34
Apgc
34
TRIZAIC UPLC Source
34
Ionkey Source
34
Intellistart Fluidics System
35
Overview
35
System Components
36
System Operation
36
Ion Optics
36
MS Operating Modes
37
MS/MS Operating Modes
38
Product (Daughter) Ion Mode
39
Precursor (Parent) Ion Mode
40
MRM Mode
40
Constant Neutral Loss Mode
41
Scanwave Daughter Scan Mode
42
Leak Sensors
42
Vacuum System
43
Rear Panel
43
Preparing the Mass Spectrometer for Operation
45
Starting the Mass Spectrometer
46
Verifying the Instrument's State of Readiness
48
Monitoring the Mass Spectrometer Leds
48
Tuning and Calibration Information
49
Running the Mass Spectrometer at High Flow Rates
50
Preparing the Intellistart Fluidics System
51
Installing the Reservoir Bottles
51
Adjusting the Solvent Delivery Tube Positions
53
Purging the Infusion Pump
54
Rebooting the Mass Spectrometer
55
Leaving the Mass Spectrometer Ready for Operation
56
Emergency Shutdown of the Mass Spectrometer
56
Changing the Mode of Operation
57
ESI Mode
57
Installing the ESI Probe
58
Removing the ESI Probe
62
Esci Mode
62
Optimizing the ESI Probe for Esci Operation
63
APCI Mode
63
Installing the Ionsabre II Probe
64
Removing the Ionsabre II Probe
67
Combined APPI/APCI Source
67
APPI Operation
67
APCI Operation
68
Dual-Mode Operation
69
The Combined APPI/APCI Source Components
70
Installing the Combined APPI/APCI Source
72
Nanoflow ESI Source
74
Installing the Nanoflow Source
76
Fitting a Borosilicate Glass Capillary (Nanovial)
78
Positioning the Borosilicate Glass Capillary Tip
81
Restarting a Stalled Borosilicate Glass Capillary Electrospray
82
Ionkey Source
82
Installing the Ionkey Source
83
Installing Ionkey Source Software
88
Installing the Camera in the Ionkey Source
89
Removing an Ionkey Source
89
Maintenance Procedures
91
Maintenance Schedule
92
Spare Parts
95
Troubleshooting with Connections INSIGHT
96
Safety and Handling
97
Preparing the Instrument for Working on the Source
98
Removing and Refitting the Source Enclosure
100
Removing the Source Enclosure from the Instrument
100
Fitting the Source Enclosure to the Instrument
102
Installing and Removing the Corona Pin
102
Installing the Corona Pin in the Source
103
Removing the Corona Pin from the Source
105
Operating the Source Isolation Valve
107
Removing O-Rings and Seals
110
Cleaning the Instrument Case
111
Emptying the Nitrogen Exhaust Trap Bottle
111
Maintaining the Oerlikon Leybold Oil-Filled Roughing Pumps
113
Gas Ballasting the Oerlikon Leybold Roughing Pumps
115
Inspecting the Roughing Pump Oil Levels
116
Adding Oil to a Roughing Pump
116
Replacing the Roughing Pumps' Oil and Oil Demister Elements
119
Gas Ballasting the Edwards Xds35I Oil-Free Roughing Pump
127
Cleaning the Source Components
128
Cleaning the Sampling Cone Assembly
129
Removing the Sampling Cone Assembly from the Source
129
Disassembling the Sampling Cone Assembly
131
Cleaning the Sample Cone and Cone Gas Nozzle
134
Assembling the Sampling Cone Assembly
136
Fitting the Sampling Cone Assembly to the Source
137
Cleaning the Ion Block Assembly
139
Removing the Ion Block Assembly from the Source Assembly
139
Disassembling the Source Ion Block Assembly
141
Cleaning the Ion Block Components
147
Assembling the Source Ion Block Assembly
149
Fitting the Ion Block Assembly to the Source Assembly
150
Cleaning the Stepwave Ion Guide Assembly
152
Handling the Stepwave Ion Guide Assembly
152
Removing the Ion Block Support from the Source Assembly
152
Removing the Stepwave Assembly from the Source Assembly
154
Disassembling the Stepwave Ion Guide Assembly
158
Cleaning the Stepwave Ion Guide Assembly
161
Assembling the Stepwave Ion Guide Assembly
165
Fitting the Stepwave Assembly to the Source Assembly
167
Fitting the Ion Block Support to the Source
170
Replacing the ESI Probe Tip and Gasket
171
Removing the ESI Probe Tip and Gasket
171
Fitting the ESI Probe Tip and Gasket
174
Replacing the ESI Probe Sample Capillary
175
Removing the Existing Capillary
175
Installing the New Capillary
180
Cleaning the Ionsabre II Probe Tip
183
Replacing the Ionsabre II Probe Sample Capillary
184
Removing the Existing Capillary
184
Installing the New Capillary
187
Cleaning or Replacing the Corona Pin
190
Replacing the Ionsabre II Probe Heater
191
Removing the Ionsabre II Probe Heater
191
Fitting the New Ionsabre II Probe Heater
193
Replacing the Ion Block Source Heater
195
Replacing the Source Assembly Seals
199
Removing the Probe Adjuster Assembly Probe and Source Enclosure Seals
199
Fitting the New Source Enclosure and Probe Adjuster Assembly Probe Seals
201
Replacing the Air Filter
203
APPI/APCI Source-Changing the UV Lamp Bulb
205
APPI/APCI Source-Cleaning the Lamp Window
207
APPI/APCI Source-Replacing the APPI Lamp Drive Seals
208
Removing the APPI Lamp Drive Assembly Seals
208
Fitting the New APPI Lamp Drive Assembly O-Rings
213
Replacing the Ionkey Source Fluid Lines
216
Removing a Fluid Line
217
Installing a Fluid Line
219
Cleaning the Ionkey Source and Connectors
220
A Safety Advisories
223
Warning Symbols
224
Specific Warnings
225
Caution Advisory
228
Warnings that Apply to All Waters Instruments and Devices
229
Warnings that Address the Replacing of Fuses
234
Electrical and Handling Symbols
236
Electrical Symbols
236
Handling Symbols
237
B External Connections
239
External Wiring and Vacuum Connections
240
Connecting the Oerlikon Leybold Oil-Filled Roughing Pumps
241
Connecting the Edwards Oil-Free Roughing Pumps
248
Making the Roughing Pump Connections to the Xevo TQ-S
254
Connecting to the Nitrogen Supply
255
Connecting to the Collision Cell Gas Supply
256
Connecting the Nitrogen Exhaust Line
257
Connecting the Liquid Waste Line
260
Connecting the Workstation
262
Connecting Ethernet Cables for an LC/MS System
263
Input/Output Signal Connectors
263
Making Signal Connections
266
Connecting to the Electricity Source
269
C Materials of Construction and Compatible Solvents
271
Preventing Contamination
272
Items Exposed to Solvent
272
Solvents Used to Prepare Mobile Phases
273
D Plumbing the Intellistart Fluidics System
275
Preventing Contamination
275
Plumbing Schematic
276
Ionkey and Trizaic Source Plumbing
277
Tubing Specifications
278
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Waters Xevo TQ-S Operator's, Overview And Maintenance Manual (256 pages)
Mass spectrometry system
Brand:
Waters
| Category:
Laboratory Equipment
| Size: 2 MB
Table of Contents
Copyright Notice
2
Trademarks
2
Customer Comments
3
Safety Considerations
4
Considerations Specific to the Xevo TQ-S System
4
Safety Advisories
6
Operating this Instrument
7
Applicable Symbols
7
Audience and Purpose
7
Intended Use of the Xevo TQ-S
7
Calibrating
8
ISM Classification
9
ISM Classification: ISM Group 1 Class a
9
EC Authorized Representative
9
Table of Contents
11
1 Waters Xevo TQ-S Overview
20
Waters Xevo TQ-S
20
ACQUITY UPLC/MS Xevo TQ-S Systems
22
Non-ACQUITY Devices for Use with the Xevo TQ-S
24
Software and Data System
24
Instrument Console Software
25
Ionization Techniques and Source Probes
25
Electrospray Ionization (ESI)
25
Combined Electrospray Ionization and Atmospheric Pressure Chemical Ionization (Esci)
25
Atmospheric Pressure Chemical Ionization (APCI)
26
Dual-Mode APPI/APCI Source
26
Nanoflow ESI Source
26
Atmospheric Solids Analysis Probe (ASAP)
27
Atmospheric Pressure Gas Chromatography (APGC)
27
TRIZAIC UPLC Source
28
Intellistart Fluidics System
28
Overview
28
System Components
29
System Operation
29
Ion Optics
30
MS Operating Modes
31
MS/MS Operating Modes
32
Product (Daughter) Ion Mode
33
Precursor (Parent) Ion Mode
34
Multiple Reaction Monitoring Mode
34
Constant Neutral Loss Mode
35
Scanwave Daughter Scan Mode
36
Leak Sensors
36
Vacuum System
36
Rear Panel
37
2 Preparing the Mass Spectrometer for Operation
40
Starting the Mass Spectrometer
40
Verifying the Instrument's State of Readiness
42
Monitoring the Mass Spectrometer Leds
42
Tuning and Calibration Information
42
Running the Mass Spectrometer at High Flow Rates
43
Preparing the Intellistart Fluidics System
44
Installing the Reservoir Bottles
44
Adjusting the Solvent Delivery Tube Positions
45
Purging the Infusion Pump
46
Rebooting the Mass Spectrometer
47
Leaving the Mass Spectrometer Ready for Operation
48
Emergency Shutdown of the Mass Spectrometer
48
3 Changing the Mode of Operation
50
ESI Mode
50
Installing the ESI Probe
50
Removing the ESI Probe
54
Esci Mode
54
Optimizing the ESI Probe for Esci Operation
54
APCI Mode
55
Installing the Ionsabre II Probe
55
Removing the Ionsabre II Probe
58
Combined APPI/APCI Source
59
APPI Operation
59
APCI Operation
60
Dual-Mode Operation
61
The Combined APPI/APCI Source Components
62
Installing the Combined APPI/APCI Source
64
Removing the Ionsabre II Probe and Combined APPI/APCI Source Enclosure
65
Nanoflow ESI Source
66
Installing the Nanoflow Source
67
Fitting a Borosilicate Glass Capillary (Nanovial)
69
Positioning the Borosilicate Glass Capillary Tip
73
Restarting a Stalled Borosilicate Glass Capillary Electrospray
73
4 Maintenance Procedures
75
Maintenance Schedule
77
Spare Parts
79
Troubleshooting with Connections INSIGHT
79
Safety and Handling
81
Preparing the Instrument for Working on the Source
82
Removal and Refitting of the Source Enclosure
83
Removing the Source Enclosure from the Instrument
83
Fitting the Source Enclosure to the Instrument
85
Installing and Removing the Corona Pin
86
Installing the Corona Pin in the Source
86
Removing the Corona Pin from the Source
89
Operating the Source Isolation Valve
90
Removing O-Rings and Seals
93
Cleaning the Instrument Case
94
Emptying the Nitrogen Exhaust Trap Bottle
94
Maintaining the Oerlikon Leybold Oil-Filled Roughing Pumps
96
Gas Ballasting the Oerlikon Leybold Roughing Pumps
97
Inspecting the Roughing Pump Oil Levels
98
Adding Oil to a Roughing Pump
98
Replacing the Roughing Pumps' Oil and Oil Demister Elements
101
Gas Ballasting the Edwards Xds46I Oil-Free Roughing Pump
110
Cleaning the Source Components
111
Cleaning the Sampling Cone Assembly
112
Removing the Sampling Cone Assembly from the Source
112
Disassembling the Sampling Cone Assembly
114
Cleaning the Sample Cone and Cone Gas Nozzle
116
Assembling the Sampling Cone Assembly
118
Fitting the Sampling Cone Assembly to the Source
119
Cleaning the Ion Block Assembly
121
Removing the Ion Block Assembly from the Source Assembly
121
Disassembling the Source Ion Block Assembly
123
Cleaning the Ion Block Components
129
Assembling the Source Ion Block Assembly
130
Fitting the Ion Block Assembly to the Source Assembly
132
Cleaning the Stepwave Ion Guide Assembly
133
Handling the Stepwave Ion Guide Assembly
133
Removing the Ion Block Support from the Source Assembly
133
Removing the Stepwave Assembly from the Source Assembly
135
Disassembling the Stepwave Ion Guide Assembly
138
Cleaning the Stepwave Ion Guide Assembly
143
Assembling the Stepwave Ion Guide Assembly
147
Fitting the Stepwave Assembly to the Source Assembly
149
Fitting the Ion Block Support to the Source
151
Replacing the ESI Probe Tip and Gasket
152
Removing the ESI Probe Tip and Gasket
152
Fitting the ESI Probe Tip and Gasket
155
Replacing the ESI Probe Sample Capillary
156
Removing the Existing Capillary
156
Installing the New Capillary
160
Cleaning the Ionsabre II Probe Tip
164
Replacing the Ionsabre II Probe Sample Capillary
165
Removing the Existing Capillary
165
Installing the New Capillary
167
Cleaning or Replacing the Corona Pin
171
Replacing the Ionsabre II Probe Heater
172
Removing the Ionsabre II Probe Heater
172
Fitting the New Ionsabre II Probe Heater
174
Replacing the Ion Block Source Heater
175
Replacing the Source Assembly Seals
179
Removing the Probe Adjuster Assembly Probe and Source Enclosure Seals
179
Fitting the New Source Enclosure and Probe Adjuster Assembly Probe Seals
181
Replacing the Air Filter
182
APPI/APCI Source-Changing the UV Lamp Bulb
184
APPI/APCI Source-Cleaning the Lamp Window
187
APPI/APCI Source-Replacing the APPI Lamp Drive Seals
188
Removing the APPI Lamp Drive Assembly Seals
188
Fitting the New APPI Lamp Drive Assembly O-Rings
194
A Safety Advisories
198
Warning Symbols
198
Task-Specific Hazard Warnings
198
Specific Warnings
199
Caution Symbol
201
Warnings that Apply to All Waters Instruments
202
Electrical and Handling Symbols
207
Electrical Symbols
207
Handling Symbols
208
B External Connections
210
Mass Spectrometer External Wiring and Vacuum Connections
210
Connecting the Oerlikon Leybold Oil-Filled Roughing Pumps
211
Making Tubing Connections
212
Connecting the Edwards Oil-Free Roughing Pumps
218
Making the Roughing Pump Connections to the Xevo TQ-S
224
Connecting to the Nitrogen Supply
225
Connecting to the Collision Cell Gas Supply
226
Connecting the Nitrogen Exhaust Line
227
Connecting the Liquid Waste Line
230
Connecting the Workstation
232
Connecting Ethernet Cables
233
Input/Output Signal Connectors
233
Making Signal Connections
236
Connecting to the Electricity Source
239
C Materials of Construction and Compatible Solvents
242
Preventing Contamination
242
Items Exposed to Solvent
242
Solvents Used to Prepare Mobile Phases
243
D Plumbing the Intellistart Fluidics System
246
Preventing Contamination
246
Plumbing Schematic
246
Index
249
Waters Xevo TQ-S Quick Start Manual (2 pages)
No flow from fluidics
Brand:
Waters
| Category:
Laboratory Equipment
| Size: 0 MB
Table of Contents
Symptoms
1
Environment
1
Cause
2
FIX or WORKAROUND
2
Additional Information
2
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