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Xevo TQD
Waters Xevo TQD Manuals
Manuals and User Guides for Waters Xevo TQD. We have
3
Waters Xevo TQD manuals available for free PDF download: Operator's, Overview And Maintenance Manual, Overview And Maintenance Manual, Knowledge Base
Waters Xevo TQD Operator's, Overview And Maintenance Manual (250 pages)
Brand:
Waters
| Category:
Laboratory Equipment
| Size: 2.55 MB
Table of Contents
Copyright Notice
2
Trademarks
2
Customer Comments
2
Contacting Waters
3
Safety Considerations
4
Considerations Specific to the Xevo TQD
4
Safety Advisories
7
Operating this Instrument
8
Applicable Symbols
8
Audience and Purpose
9
Intended Use of the Xevo TQD
9
Quality Control
9
ISM Classification
11
ISM Classification: ISM Group 1 Class a
11
EC Authorized Representative
11
Table of Contents
13
1 Specifications and Operating Modes
22
Uses and Compatibility
22
ACQUITY H-Class and Nanoacquity Xevo TQD UPLC/MS Systems
25
Non-ACQUITY Devices for Use with the Xevo TQD
27
Software and Data System
27
Instrument Console Software
28
Ionization Techniques and Source Probes
29
Electrospray Ionization (ESI)
29
Combined ESI and APCI (Esci)
29
Atmospheric Pressure Chemical Ionization (APCI)
29
Dual-Mode APPI/APCI Source
29
Nanoflow Source
30
Atmospheric Solids Analysis Probe (ASAP)
30
Atmospheric Pressure Gas Chromatography (APGC)
31
TRIZAIC UPLC Source
31
Intellistart Fluidics System
31
Functionality
31
System Operation
32
Ion Optics
33
MS Operating Modes
34
MS/MS Operating Modes
35
Product (Daughter) Ion Mode
36
Precursor (Parent) Ion Mode
37
Multiple Reaction Monitoring Mode
37
Constant Neutral Loss Mode
39
Sample Inlet
39
Leak Sensors
40
Vacuum System
40
Rear Panel Connections
41
2 Preparing for Operation
44
Starting the Mass Spectrometer
44
Verifying the Instrument's State of Readiness
46
Monitoring the Instrument Leds
46
Tuning and Calibration Information
46
Running the Instrument at Different Flow Rates
47
Preparing the Intellistart Fluidics System
48
Installing the Reservoir Bottles
48
Purging the Infusion Pump
50
Rebooting the Instrument
50
Leaving the Mass Spectrometer Ready for Operation
51
Emergency Shutdown of the Mass Spectrometer
51
3 Changing the Mode of Operation
54
ESI Mode
54
Installing the ESI Probe
54
Removing the ESI Probe
56
Esci Mode
57
Optimizing the ESI Probe for Esci Operation
57
APCI Mode
57
Installing the Ionsabre II Probe
58
Removing the Ionsabre II Probe
60
Combined APPI/APCI Source
61
APPI Operation
61
APCI Operation
62
Dual-Mode Operation
63
The Combined APPI/APCI Source Components
64
Installing the Combined APPI/APCI Source
65
Removing the Ionsabre II Probe and APPI/APCI Source Enclosure
67
Nanoflow Source
68
Installing the Nanoflow Source
69
Fitting a Borosilicate Glass Capillary (Nanovial)
71
Positioning the Borosilicate Glass Capillary Tip
74
Restarting a Stalled Borosilicate Glass Capillary Electrospray
75
4 Maintenance Procedures
77
Maintenance Schedule
79
Spare Parts
81
Troubleshooting with Connections INSIGHT
82
Safety and Handling
83
Preparing the Instrument for Working on the Source
83
Removing and Refitting the Source Enclosure
84
Removing the Source Enclosure from the Instrument
84
Fitting the Source Enclosure to the Instrument
87
Installing and Removing the Corona Pin
88
Installing the Corona Pin in the Source
88
Removing the Corona Pin from the Source
91
Operating the Source Isolation Valve
92
Removing O-Rings and Seals
95
Cleaning the Instrument Case
96
Emptying the Exhaust Trap Bottle
96
Gas Ballasting the Roughing Pump
98
Gas Ballasting a Pump with a Screwdriver-Operated Gas Ballast Valve
99
Gas Ballasting a Pump with a Handle-Operated Gas Ballast Valve
100
Checking the Roughing Pump Oil Level
101
Adding Oil to the Roughing Pump
101
Cleaning the Source Components
103
Cleaning the Sampling Cone Assembly
104
Removing the Sampling Cone Assembly from the Source
104
Disassembling the Sampling Cone Assembly
106
Cleaning the Sample Cone and Cone Gas Nozzle
108
Assembling the Sampling Cone Assembly
110
Fitting the Sampling Cone Assembly to the Source
111
Cleaning the Extraction Cone
113
Removing the Ion Block Assembly from the Source Assembly
113
Removing the Extraction Cone from the Ion Block
115
Cleaning the Extraction Cone
116
Fitting the Extraction Cone to the Ion Block
118
Fitting the Ion Block Assembly to the Source Assembly
119
Cleaning the Ion Block Assembly
120
Disassembling the Source Ion Block Assembly
120
Cleaning the Ion Block Components
127
Assembling the Source Ion Block Assembly
129
Cleaning the Ion Guide Assembly
131
Removing the Ion Block Assembly and Ion Guide from the Source Assembly
131
Cleaning the Ion Guide Assembly
133
Removing the Differential Aperture from the Ion Guide
136
Fitting the Differential Aperture to the Ion Guide Assembly
138
Fitting the Ion Guide Assembly to the Source Assembly
139
Fitting the Ion Block Support to the Source
139
Replacing the ESI Probe Tip and Gasket
141
Removing the ESI Probe Tip and Gasket
141
Fitting the ESI Probe Tip and Gasket
143
Replacing the ESI Probe Sample Capillary
145
Removing the Existing Capillary
145
Installing the New Capillary
149
Cleaning the Ionsabre II Probe Tip
153
Replacing the Ionsabre II Probe Sample Capillary
154
Removing the Existing Capillary
154
Installing the New Capillary
156
Cleaning or Replacing the Corona Pin
160
Replacing the Ionsabre II Probe Heater
161
Removing the Ionsabre II Probe Heater
161
Fitting the New Ionsabre II Probe Heater
162
Replacing the Ion Block Source Heater
163
Replacing the Source Assembly Seals
168
Removing the Probe Adjuster Assembly Probe and Source Enclosure Seals
168
Fitting the New Source Enclosure and Probe Adjuster Assembly Seals
170
Replacing the Air Filter
171
Replacing the Roughing Pump Oil
173
Replacing the Roughing Pump's Oil Demister Element
176
APPI/APCI Source-Changing the UV Lamp Bulb
182
APPI/APCI Source-Cleaning the Lamp Window
183
APPI/APCI Source-Replacing the APPI Lamp Drive Seals
184
Removing the APPI Lamp Drive Assembly Seals
184
Fitting the New APPI Lamp Drive Assembly O-Rings
191
Replacing the Instrument's Fuses
193
A Safety Advisories
196
Warning Symbols
196
Task-Specific Hazard Warnings
196
Specific Warnings
197
Caution Symbol
199
Warnings that Apply to All Waters Instruments
199
Electrical and Handling Symbols
206
Electrical Symbols
206
Handling Symbols
207
B External Connections
210
External Wiring and Vacuum Connections
210
Connecting the Oil-Filled Roughing Pump
211
Making the Electrical Connections to the Oil-Filled Roughing Pump
215
Connecting the Edwards Oil-Free Roughing Pump
216
Making the Electrical Connections to the Edwards Oil-Free Roughing Pump
219
Connecting to the Nitrogen Gas Supply
220
Connecting to the Collision Cell Gas Supply
222
Connecting the Nitrogen Exhaust Line
222
Connecting the Liquid Waste Line
225
Connecting the Workstation
227
Connecting Ethernet Cables
227
I/O Signal Connectors
228
Signal Connections
230
Connecting to the Power Supply
233
C Materials of Construction and Compliant Solvents
236
Preventing Contamination
236
Items Exposed to Solvent
236
Solvents Used to Prepare Mobile Phases
237
D Plumbing the Intellistart Fluidics System
240
Preventing Contamination
240
The Selector Valve
240
Plumbing Schematic
241
Tubing and Connection Specifications
241
Index
243
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Waters Xevo TQD Overview And Maintenance Manual (250 pages)
Brand:
Waters
| Category:
Laboratory Equipment
| Size: 2.88 MB
Table of Contents
Trademarks
3
Customer Comments
4
Safety Considerations
4
Safety Hazard Symbol Notice
5
FCC Radiation Emissions Notice
9
Electrical Power Safety Notice
9
Operating this Instrument
10
Applicable Symbols
10
Audience and Purpose
12
Intended Use of the Xevo TQD
12
Calibrating
12
Quality Control
12
EMC Considerations
13
Canada Spectrum Management Emissions Notice
13
ISM Classification: ISM Group 1 Class a
13
EC Authorized Representative
14
Table of Contents
15
1 Specifications and Operating Modes
23
Uses and Compatibility
24
ACQUITY Xevo TQD UPLC/MS Systems
26
Non-ACQUITY Devices for Use with the Xevo TQD
29
Software and Data System
29
Ionization Techniques and Source Probes
31
Electrospray Ionization (ESI)
31
Combined ESI and APCI (Esci)
31
Atmospheric Pressure Chemical Ionization (APCI)
31
Dual-Mode APPI/APCI Source
32
Nanoflow Source
32
Atmospheric Solids Analysis Probe (ASAP)
33
Atmospheric Pressure Gas Chromatography (APGC)
33
TRIZAIC UPLC Source
33
Intellistart Fluidics System
34
Functionality
34
System Operation
35
Ion Optics
36
MS Operating Modes
37
MS/MS Operating Modes
38
Product (Daughter) Ion Mode
39
Precursor (Parent) Ion Mode
40
Multiple Reaction Monitoring Mode
40
Constant Neutral Loss Mode
42
Sample Inlet
43
Leak Sensors
43
Vacuum System
43
Rear Panel Connections
44
2 Preparing for Operation
45
Starting the Mass Spectrometer
46
Verifying the Instrument's State of Readiness
50
Monitoring the Instrument Leds
50
Tuning and Calibration Information
50
Running the Instrument at Different Flow Rates
51
Preparing the Intellistart Fluidics System
52
Installing the Reservoir Bottles
52
Purging the Infusion Pump
54
Rebooting the Instrument
54
Leaving the Mass Spectrometer Ready for Operation
55
Emergency Shutdown of the Mass Spectrometer
55
3 Changing the Mode of Operation
57
ESI Mode
58
Installing the ESI Probe
58
Removing the ESI Probe
61
Esci Mode
62
Optimizing the ESI Probe for Esci Operation
62
APCI Mode
62
Installing the Ionsabre II Probe
63
Removing the Ionsabre II Probe
65
Combined APPI/APCI Source
66
APPI Operation
66
APCI Operation
67
Dual-Mode Operation
68
The Combined APPI/APCI Source Components
69
Installing the Combined APPI/APCI Source
71
Removing the Ionsabre II Probe and APPI/APCI Source Enclosure
72
Nanoflow Source
73
Installing the Nanoflow Source
74
Fitting a Borosilicate Glass Capillary (Nanovial)
77
Positioning the Borosilicate Glass Capillary Tip
80
Restarting a Stalled Borosilicate Glass Capillary Electrospray
80
4 Maintenance Procedures
81
Maintenance Schedule
83
Spare Parts
85
Troubleshooting with Connections INSIGHT
86
Safety and Handling
87
Preparing the Instrument for Operations on or Inside Its Source
88
Removing and Refitting the Source Enclosure
90
Removing the Source Enclosure from the Instrument
90
Fitting the Source Enclosure to the Instrument
92
Installing and Removing the Corona Pin
93
Installing the Corona Pin in the Source
93
Removing the Corona Pin from the Source
95
Operating the Source Isolation Valve
96
Removing O-Rings and Seals
99
Cleaning the Instrument Case
100
Emptying the Exhaust Trap Bottle
100
Gas Ballasting the Roughing Pump
102
Gas Ballasting a Pump Fitted with a Screwdriver-Operated Gas Ballast Valve
103
Gas Ballasting a Pump Fitted with a Handle-Operated Gas Ballast Valve
105
Checking the Roughing Pump Oil Level
106
Adding Oil to the Roughing Pump
106
Cleaning the Source Components
108
Cleaning the Sampling Cone Assembly
109
Removing the Sampling Cone Assembly from the Source
109
Disassembling the Sampling Cone Assembly
111
Cleaning the Sample Cone and Cone Gas Nozzle
114
Assembling the Sampling Cone Assembly
116
Fitting the Sampling Cone Assembly to the Source
117
Cleaning the Extraction Cone
119
Removing the Ion Block Assembly from the Source Assembly
119
Removing the Extraction Cone from the Ion Block
121
Cleaning the Extraction Cone
123
Fitting the Extraction Cone to the Ion Block
125
Fitting the Ion Block Assembly to the Source Assembly
125
Cleaning the Ion Block Assembly
126
Disassembling the Source Ion Block Assembly
126
Cleaning the Ion Block Components
133
Assembling the Source Ion Block Assembly
135
Cleaning the Ion Guide Assembly
137
Removing the Ion Block Assembly and Ion Guide from the Source Assembly
137
Cleaning the Ion Guide Assembly
140
Removing the Differential Aperture from the Ion Guide
142
Fitting the Differential Aperture to the Ion Guide Assembly
144
Fitting the Ion Guide Assembly to the Source Assembly
145
Fitting the Ion Block Support to the Source
145
Replacing the ESI Probe Tip and Gasket
147
Removing the ESI Probe Tip and Gasket
147
Fitting the ESI Probe Tip and Gasket
150
Replacing the ESI Probe Sample Capillary
151
Removing the Existing Capillary
151
Installing the New Capillary
155
Cleaning the Ionsabre II Probe Tip
159
Replacing the Ionsabre II Probe Sample Capillary
160
Removing the Existing Capillary
160
Installing the New Capillary
162
Cleaning or Replacing the Corona Pin
166
Replacing the Ionsabre II Probe Heater
167
Removing the Ionsabre II Probe Heater
167
Fitting the New Ionsabre II Probe Heater
169
Replacing the Ion Block Source Heater
170
Replacing the Source Assembly Seals
174
Removing the Probe Adjuster Assembly Probe and Source Enclosure Seals
174
Fitting the New Source Enclosure and Probe Adjuster Assembly Seals
176
Replacing the Air Filter
178
Replacing the Roughing Pump Oil
180
Replacing the Roughing Pump's Oil Demister Element
183
APPI/APCI Source-Changing the UV Lamp Bulb
188
APPI/APCI Source-Cleaning the Lamp Window
189
APPI/APCI Source-Replacing the APPI Lamp Drive Seals
191
Removing the APPI Lamp Drive Assembly Seals
191
Fitting the New APPI Lamp Drive Assembly O-Rings
197
Replacing the Instrument's Fuses
199
A Safety Advisories
201
Warning Symbols
202
Specific Warnings
203
Notices
206
Prohibition Symbol
206
Warnings that Apply to All Waters Instruments and Devices
207
Warnings that Address the Replacing of Fuses
212
Electrical and Handling Symbols
214
Electrical Symbols
214
Handling Symbols
215
B External Connections
217
External Wiring and Vacuum Connections
218
Connecting the Oil-Filled Roughing Pump
219
Connecting Electric Cables to the Oil-Filled Roughing Pump
223
Connecting the Edwards Oil-Free Roughing Pump
224
Connecting Electric Cables to the Edwards Oil-Free Roughing Pump
227
Connecting to the Nitrogen Gas Supply
228
Connecting to the Collision Cell Gas Supply
230
Connecting the Nitrogen Exhaust Line
230
Connecting the Liquid Waste Line
233
Connecting the Workstation
235
Connecting Ethernet Cables
236
I/O Signal Connectors
237
Signal Connections
238
Connecting to the Power Supply
241
C Materials of Construction and Compliant Solvents
243
Preventing Contamination
244
Items Exposed to Solvent
244
Solvents Used to Prepare Mobile Phases
245
D Plumbing the Intellistart Fluidics System
247
Preventing Contamination
248
The Selector Valve
248
Plumbing Schematic
249
Tubing and Connection Specifications
250
Waters Xevo TQD Knowledge Base (2 pages)
Brand:
Waters
| Category:
Laboratory Equipment
| Size: 0.05 MB
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