Gambro Cobe Spectra Essentials Manual page 79

Configuring the Inlet:AC Ratio
The inlet:AC ratio is the ratio of the inlet pump flow rate to the AC
pump flow rate. It determines the anticoagulation level in the system.
You can configure the inlet:AC ratio to between 2:1 and 50:1. Table 5-1
shows the default ratio setting for each procedure, and where in the
manual to find instructions for configuring the ratio. The medical staff
should determine the default ratio configuration based on their
requirements for the apheresis procedures.
Gambro BCT has not validated ratios higher than 15:1. Higher ratios
may cause interface instability and platelet aggregates to form in the
extracorporeal circuit and/or collection bag, and may affect cellular
viability. The amount of AC stored with the product (during platelet or
WBC procedures) influences the storage environment of the collected
cells. Using inadequate amounts of anticoagulant may result in the
formation of microaggregates or clots in the product.
®
COBE Spectra™ Apheresis System • Essentials Guide
Table 5-1: Default procedure inlet:AC ratios
Default Inlet:AC
Procedure
Ratio
ELP, LRS, LRST medium automatic
TPE
AutoPBSC
MNC
PMN
Software Options and Configuration
Configuration Instructions
Platelet Collection Guide,
range
Chapter 2
10:1 Therapeutic Apheresis
Guide, Chapter 2
12:1 Cell Therapy Guide,
Chapter 4
12:1 Cell Therapy Guide,
Chapter 2
13:1 Cell Therapy Guide,
Chapter 3
5-5