Gambro Cobe Spectra Essentials Manual page 108

Anticoagulation
Managing Clumping
During platelet collection, platelet depletion, and WBC procedures,
clumping may occasionally occur in the collect line. You can reduce
clumping by decreasing the inlet:AC ratio. The Spectra system decreases
the inlet pump flow rate while maintaining the rate at which
anticoagulant is delivered to the donor/patient. This does not increase
the risk of hypocalcemia. Increasing the amount of citrate in relation to
the total volume of extracorporeal blood modifies the pH and ionized
calcium environment and helps reduce clumping. When a high
concentration of platelets is the cause of the clumping, you can increase
the collect pump flow rate to improve the situation. For more
information, see "Decreasing Platelet Activation or "Clumping"" in
Chapter 5 of the Platelet Collection Guide.
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8-6 COBE Spectra™ Apheresis System • Essentials Guide