5. The ion beam is focused in an ion guide before it enters the quadrupole, where the ions
are filtered according to their mass-to-charge ratio.
6. The mass-separated ions pass through a collision cell where they can undergo collision-
induced dissociation (CID).
7. The ions pass through a hexapole ion guide before entering the XS ion optics, where they
are collisionally cooled and focused.
8. The ions pass into the time-of-flight (Tof) analyzer. A high voltage pulse orthogonally
accelerates the ions up the flight tube where a reflectron reflects them back toward the
detector. Ions of different mass-to-charge ratios arrive at the detector at different times.
The difference in the arrival times provides the basis for a mass spectrum.
9. The signal from the detector is amplified, digitized, and transmitted to the software.
Figure 1–5: Ion optics overview
Detector
To vacuum pump
Pusher
Hexapole ion guide
To vacuum pumps
To vacuum pumps
To vacuum pump
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