Troubleshooting; General Principles - Waters ACQUITY UPLC M-Class System Manual

Table 4–3: µSM-FL maintenance procedures (continued)
Maintenance procedure
Replace the sample syringe
Replace the injection valve cartridge
Table 4–4: TVM maintenance procedures
Maintenance procedure
Replace the column
Replace the valve cartridge
Clean the device's exterior with a soft, lint-
free cloth, or paper dampened with water

4.3 Troubleshooting

When a malfunction occurs, you must systematically troubleshoot the system to isolate the
problem.

4.3.1 General principles

Follow these general principles for troubleshooting the ACQUITY UPLC M-Class system:
November 26, 2019, 715003588 Revision C
Page 63
Frequency
As part of the annual scheduled routine
maintenance and thereafter, as needed.
These are the typical failure modes:
• The sample syringe leak test fails.
• Air bubbles are in the syringe.
• A sample syringe hardware error
message appears.
As needed.
Frequency
As needed. The typical failure modes are as
follows:
• High back pressure: the column causes a
high-pressure shutdown.
• Method requirements are not met, as
evidenced by poor peak shape, resolution
between peaks lost, tailing, and so on.
Perform a plate count to establish column
efficiency.
As needed.
Perform as part of annual routine scheduled
maintenance and when solvent or dust
accumulates.