D Solvent Considerations; Solvent Guidelines; Clean Solvents; Solvent Quality - Waters ACQUITY UPLC M-Class System Manual

D
Solvent considerations
This information applies to the ACQUITY UPLC M-Class System modules.
Warning:
working with hazardous materials. Consult the Safety Data Sheets regarding the
solvents you use. Additionally, consult the safety representative for your organization
regarding its protocols for handling such materials.
Warning:
in the latest edition of the National Research Council's publication, Prudent Practices in
the Laboratory: Handling and Management of Chemical Hazards.
See also:
Controlling Contamination in Ultra Performance LC/MS and HPLC/MS Systems on
the documentation CD.
D.1 Solvent guidelines
D.1.1 Clean solvents
Clean solvents ensure reproducible results and permit operation with instrument maintenance.
Dirty solvents can cause baseline noise and drift, and they can clog solvent reservoir filters, inlet
filters, and capillary lines.
D.1.2 Solvent quality
Use LC/MS-grade solvents for the best possible results. Filter solvents through a 0.2-µm
membrane filter. Small particles can permanently block a system's capillary lines. Filtering
solvents also improves check-valve performance.
Recommendation:
with each other, and that you follow the manufacturers' recommendations.
D.1.3 Solvent preparation
Proper solvent preparation, primarily filtration, can prevent many pumping problems.
Observe Good Laboratory Practice (GLP) at all times, particularly when
Guidelines prescribing the proper use and handling of such materials appear
Ensure that you choose solvents and membrane filters that are compatible
November 26, 2019, 715003588 Revision C
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