Thermo Scientific Vanquish VH-D10 Operating Manual page 94

6 • Operation
Devices in the Flow Path After the Flow Cell
Interrupted operation
Page 94
NOTICE
If using multi-detector configurations, configurations that include a
diverter valve, and hyphenated techniques like LC-MS or fractionation
after a LightPipe flow cell, install an overpressure relief valve. The valve
is intended to limit pressure in an error case. It is not intended to limit
overpressure events as a consequence of the system configuration and/
or instrument method not observing the flow cell pressure limit.
Repetitive triggers due to such instrument methods limit the ability of
the valve to function correctly and reduce the lifetime of the flow cell.
To protect the flow cell against overpressure and pressure shocks,
observe the following:
- Set up instrument methods that ensure that the pressure inside the
flow cell stays well within its pressure specification (for information on
how to determine the pressure inside the flow cell of a configuration,
see the Determining the Pressure inside the Flow Cell section in this
manual).
- Observe the pressure limit at all times.
- If the valve has opened, find, and resolve the root cause for opening
and ensure that the valve is tight before restarting measurements.
- If using mass spectrometers with diverter valves that offer a Make-
Before-Break connection, use this capability.
• During short analysis breaks, take appropriate measures to protect
the flow cell:
Never leave any substances in the flow cell without flow. Avoid
¨
leaving particularly any aggressive solvents in the flow cell for a
longer time.
Without flow, air bubbles in the flow cell can accelerate the
¨
deposition of substances. Never leave air bubbles in the flow cell
without flow.
If the lamp is turned on, close the shutter in the light path
¨
before the flow cell to protect the flow cell from the UV light.
Additionally, follow the guidelines in
¨
(Interruption of Operation)
Short-Term Shutdown
(} page 106).
Diode Array Detectors (VH-D10)
Operating Manual