Abbott i-STAT 1 System Manual page 515

Non-Heart Failure Population - Females (Age Group)
Sample Size (N=)
Median (pg/mL)
Mean (pg/mL)
SD (pg/mL)
95th Percentile
Percentage < 100 pg/mL
Minimum (pg/mL)
Maximum (pg/mL)
* Representative data, results in individual laboratories may vary from these data.
Due to demographic population differences, the reference range should be established at each laboratory.
Heart Failure Population
Plasma samples from 693 patients with diagnosed heart failure (231 females, 462 males) were tested
with the AxSYM BNP assay. All patients in this population were categorized according to the functional
classification system published by the New York Heart Association (NYHA).
failure patients into one of four categories of increasing disease progression (classes I to IV) based upon
a subjective assessment of the patient's clinical signs and symptoms. The data from this study are
summarized in the following table.*
Sample Size (N=)
Median (pg/mL)
Mean (pg/mL)
SD (pg/mL)
5th Percentile
95th Percentile
Percentage ≥ 100 pg/mL
Minimum (pg/mL)
Maximum (pg/mL)
Rev. Date: 01-Jul-13
<45
All
Years
465 98
26 23
46 34
70 37
150 89
88.4% 95.9%
0 0
837 263
Heart Failure Population - All
All
693
298
578
771
14
2154 1257
74.2% 58.1%
0
>4000 1651
Art: 716969-01H
45-54 55-64
Years Years
75 77
23 37
34 51
36 48
111 155
90.7% 89.6%
0 0
142 230
This system divides heart
22
NYHA Functional Class
I II
124 319 190
133 266 335
320 432 656
388 574 841
9 15
1534 2516
73.0% 79.0%
3 0
>4000 >4000
65-74 75+
Years Years
133 82
23 25
46 69
63 126
159 266
85.7% 80.5%
0 0
374 837
III IV
60
1531
1635
1097
12 188
>4000
98.3%
0 14
>4000
BNP - 5