Abbott i-STAT 1 System Manual page 461

5) Bromide has been tested at two levels: the CLSI recommended level and a therapeutic plasma
concentration level of 2.5 mmol/L. The latter is the peak plasma concentration associated with halothane
anesthesia, in which bromide is released. APOC has not identified a therapeutic condition that would
lead to levels consistent with the CLSI recommended level. Bromide tested at concentrations of 2.5 and
37.5 mmol/L interfered with i-STAT creatinine results.
6) The dependence of the i-STAT creatinine with respect to Carbon Dioxide (CO
For Crea values below 2 mg/dL:
For PCO values above 40 mmHg, the values are increased by 6.9% for every 10 mmHg
2
For PCO values below 40 mmHg, the values are decreased by 6.9% for every 10 mmHg
2
[Cr]corrected = [Cr]istat X { 1 - ( 0.069 X [(PCO
For Crea values above 2 mg/dL:
For PCO values above 40, the values are decreased by 3.7% for every 10 mmHg
2
For PCO values below 40, the values are increased by 3.7% for every 10 mmHg
2
[Cr]corrected = [Cr]istat X { 1 - ( 0.037 X [(40 - PCO
7) Nithiodote (sodium thiosulfate) is indicated for the treatment of acute cyanide poisoning. The journal
article titled "Falsely increased chloride and missed anion gap elevation during treatment with sodium
thiosulfate" indicated that sodium thiosulfate could be used in the treatment of calciphylaxis indicating that
"the highest concentration likely to be seen in plasma [is] after infusion of a 12.5 g dose of sodium thio-
sulfate pentahydrate. Assuming that the 12.5 g dose of sodium thiosulfate pentahydrate is distributed in
a typical blood volume of 5 L with a hematocrit of 40%, the peak sodium thiosulfate plasma concentration
expected is 16.7 mmol/L."
*It is possible that other interfering substance may be encountered. The degree of interference at concentrations other than those listed might not be
predictable.
Rev. Date: 15-Jul-16
13
Art: 714183-01W
-40)/10]) }
2
)/10]) }
2
) is as follows:
2
Crea - 5