Abbott i-STAT 1 System Manual page 399

Slope
Int't
Sy.x
Xmin
Xmax
r
Cartridge Comparison
The performance characteristics of the sensors are equivalent in all cartridge configurations. System
difference analysis was performed on 40 patient samples using the i-STAT 6+ and i-STAT EC4+
cartridges. In the 130–150 mmol/L range the average difference was 0.750.
Factors Affecting Results*
Sodium heparin may increase sodium results up to 1 mmol/L
Hemodilution of the plasma by more than 20% associated with priming cardiopulmonary bypass
pumps, plasma volume expansion or other fluid administration therapies using certain solutions may
cause clinically significant error on sodium, chloride, ionized calcium and pH results. These errors are
associated with solutions that do not match the ionic characteristics of plasma. To minimize these
errors when hemodiluting by more than 20%, use physiologically balanced multi-electrolyte solutions
containing low-mobility anions (e.g., gluconate).
Interference studies were based on CLSI guideline EP7-A2
CLSI guideline unless otherwise indicated.
When added to a plasma pool the following substances (at the concentrations indicated) were
found to interfere with the i-STAT sodium assay:
Substance
Bromide
Nithiodote (sodium thiosulfate)
The following substances are known not to significantly interfere with the i-STAT sodium assay at
the stated test concentrations:
Substance
Acetaminophen
Acetylcysteine
Ascorbate
Bromide (therapeutic)
β-Hydroxybutyrate
Lactate
Magnesium Chloride
Salicylate
Rev. Date: 15-Jul-16
1.00 0.98
-0.11 3.57
1.17 1.04
126 120
148 148
0.865 0.937
Test Concentration
(mmol/L)
Art: 714173-01P
0.95
5.26
1.53
124
148
0.838
.
6
. Test concentrations used were as per the
7
37.5
Increased i-STAT Sodium results.
16.7
12
Test Concentration
Interference
Use another method.
See Note 1 below.
See Note 2 below.
(mmol/L)
1.32
10.2
0.34
2.5
8,9,10
6.0
11
6.6
1.0
4.34
NA - 3