Abbott i-STAT 1 System Manual page 437

decrease ionized calcium results by approximately 0.03 mmol/L.
5) Nithiodote (sodium thiosulfate) is indicated for the treatment of acute cyanide poisoning. The
journal article titled "Falsely increased chloride and missed anion gap elevation during treatment with
sodium thiosulfate" indicated that sodium thiosulfate could be used in the treatment of calciphylaxis
indicating that "the highest concentration likely to be seen in plasma [is] after infusion of a 12.5 g dose
of sodium thiosulfate pentahydrate. Assuming that the 12.5 g dose of sodium thiosulfate pentahydrate is
distributed in a typical blood volume of 5 L with a hematocrit of 40%, the peak sodium thiosulfate plasma
concentration expected is 16.7 mmol/L."
14
*It is possible that other interfering substances may be encountered. The degree of interference at concentrations other than those listed might not
be predictable.
iCa - 5
Rev. Date: 15-Jul-16 Art: 714179-01P