Abbott i-STAT 1 System Manual page 465

Precision Data
(mmol/L)
Method Comparison
(mmol/L)
n
Sxx
Syy
Slope
Int't
Sy.x
Xmin
Xmax
r
Factors Affecting Results*
Special collection procedures are necessary to prevent changes in lactate both during and after the blood
is drawn. For steady state lactate concentrations, patients should be at rest for 2 hours and fasting. Venous
samples should be obtained without the use of a tourniquet or immediately after the tourniquet is applied.
Both venous and arterial samples may be collected into heparinized syringes.
Samples for lactate should be analyzed immediately on drawing as lactate increases by as much as 70%
within 30 minutes at 25 ºC as a result of glycolysis.
Interference studies were based on CLSI guideline EP7-A2.
CLSI guideline unless otherwise indicated.
When added to a plasma pool the following substances (at the concentrations indicated) were
found to interfere with the i-STAT lactate assay:
Substance
Bromide
Glycolic Acid
Hydroxyurea
The following substances are known not to significantly interfere with the i-STAT lactate assay at
the stated test concentrations:
Substance
Acetaldehyde
Acetaminophen
Acetylcysteine
Ascorbate
Bromide (therapeutic)
Dopamine
Formaldehyde
β-Hydroxybuterate
Pyruvate
Salicylate
Uric Acid
Rev. Date: 15-Jul-16
Aqueous Control
Level 1
Level 3
Radiometer ABL 725
(whole blood vs.
whole blood)
47
0.123
0.136
1.02
0.12
0.18
0.80
14.20
0.998
2
Test Concentration
(mmol/L)
37.5
10.0
16
0.92
Art: 714184-01O
n Mean
120 6.35
120 0.81
Hitachi 917
(i-STAT whole blood vs.
Hitachi plasma)
0.084
0.079
-0.32
14.24
0.997
Test concentrations used were as per the
15
Interference
Use another method.
See Note below
Increased i-STAT lactate results.
Use another method.
Increased i-STAT lactate results.
Use another method.
Test Concentration
(mmol/L)
0.045
1.32
10.2
0.34
2.5
17,18,19
0.006
0.133
6.0
0.31
4.34
1.4
SD %CV
0.08 1.21
0.03 3.27
47
1.06
0.17
1.77
16
16
20
LAC - 3