Abbott i-STAT 1 System Manual page 400

Note:
1) Bromide has been tested at two levels: the CLSI recommended level and a therapeutic plasma
concentration level of 2.5 mmol/L. The latter is the peak plasma concentration associated with
halothane anesthesia, in which bromide is released. APOC has not identified a therapeutic condition
that would lead to levels consistent with the CLSI recommended level. Bromide at a concentration of
37.5 mmol/L increased i-STAT sodium results, while a therapeutic range of bromide (2.5 mmol/L) did not
significantly interfere with i-STAT sodium results.
2) Nithiodote (sodium thiosulfate) is indicated for the treatment of acute cyanide poisoning. The
journal article titled "Falsely increased chloride and missed anion gap elevation during treatment with
sodium thiosulfate" indicated that sodium thiosulfate could be used in the treatment of calciphylaxis
indicating that "the highest concentration likely to be seen in plasma [is] after infusion of a 12.5 g dose
of sodium thiosulfate pentahydrate. Assuming that the 12.5 g dose of sodium thiosulfate pentahydrate
is distributed in a typical blood volume of 5 L with a hematocrit of 40%, the peak sodium thiosulfate
plasma concentration expected is 16.7 mmol/L."
12
*It is possible that other interfering substances may be encountered. The degree of interference at concentrations other than those listed might not
be predictable.
NA - 4
Art: 714173-01P Rev. Date: 15-Jul-16