Abbott i-STAT 1 System Manual page 460

The following substances are known not to significantly interfere with the i‑STAT Creatinine assay
at the stated test concentrations:
Substance
Acetaldehyde
Acetaminophen (therapeutic)
Acetylcysteine (therapeutic)
Bicarbonate
Bilirubin
Calcium Chloride
Dopamine
Formaldehyde
β–Hydroxybutyrate
Lactate
Methyldopa
Pyruvate
Salicylate
Uric Acid
Notes:
1) The normal range of creatine concentration in plasma is 0.17–0.70 mg/dL (13 – 53 µmol/L) in males
and 0.35 – 0.93 mg/dL (27 – 71 µmol/L) in females.
supplements, experiencing muscle trauma or other primary or secondary myopathies, taking statins for
hyperlipidemia control, or in patients with hyperthyroidism or a rare genetic defect of the creatine trans-
porter protein.
2) Hydroxyurea is a DNA synthesis inhibitor used in the treatment of various forms of cancer, sickle cell
anemia, and HIV infection. This drug is used to treat malignancies including melanoma, metastatic ovar-
ian cancer, and chronic myelogenous leukemia. It is also used in the treatment of polycythemia vera,
thrombocythemia, and psoriasis. At typical doses ranging from 500 mg to 2 g/day, concentrations of
hydroxyurea in patients' blood may be sustained at approximately 100 to 500 µmol/L. Higher concentra-
tions may be observed soon after dosing or at higher therapeutic doses.
3) Acetaminophen has been shown to interfere at a concentration proscribed by the CLSI guideline,
1.32 mmol/L, which represents a toxic concentration. Acetaminophen at 0.132 mmol/L, which represents
the upper end of the therapeutic concentration, has been shown not to significantly interfere with i-STAT
creatinine results.
4) Acetylcysteine has been tested at two levels: the CLSI recommended level and a concentration of
0.30 mmol/L. The latter is 3 times the peak plasma therapeutic concentration associated with treatment
to reverse acetaminophen poisoning. APOC has not identified a therapeutic condition that would lead
to levels consistent with the CLSI recommended level. Acetylcysteine at a concentration of 10.2 mmol/L
increased i-STAT creatinine results, while acetylcysteine at a concentration of 0.3 mmol/L did not signifi-
cantly interfere with i-STAT creatinine results.
Crea - 4
Test Concentration
Creatine may be elevated in patients using creatine
9
Art: 714183-01W
(mmol/L)
0.045
9
0.132
9
0.3
10,11
35.0
0.342
5.0
0.006
0.133
9
6.0
12
6.6
0.071
0.31
4.34
1.4
Rev. Date: 15-Jul-16