Waters Xevo TQD Overview And Maintenance Manual page 41

PICS mode
A variation on MRM, PICS allows you to collect a product ion spectrum from
the top of all detected peaks in MRM mode for additional confidence in your
peak assignment, activated by a single check box.
RADAR
In RADAR mode the Xevo TQD rapidly alternates between MRM and full scan
MS acquisition modes. The instrument tracks target analytes with precision
in MRM mode, while at the same time scanning (in MS mode) the background
for all other components. This enables fast characterization of potential
matrix effects, providing a platform for more robust method development
Typical application
You typically use RADAR mode during method development prior to
performing MRM or PICS to quantify known analytes in complex samples:
• Drug metabolite and pharmacokinetic studies
• Environmental, for example, pesticide and herbicide analysis
• Forensic or toxicology, for example, screening for target drugs in sports
MRM analysis with no associated RADAR or PICS operation does not produce
a spectrum because only one transition is monitored at a time. As in SIR
mode, a chromatogram is produced.
MS/MS operating modes
March 14, 2014, 715004387 Rev. B 41