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Xevo TQ-XS Mass
Waters Xevo TQ-XS Mass Spectrometer Manuals
Manuals and User Guides for Waters Xevo TQ-XS Mass Spectrometer. We have
1
Waters Xevo TQ-XS Mass Spectrometer manual available for free PDF download: Overview And Maintenance Manual
Waters Xevo TQ-XS Mass Overview And Maintenance Manual (213 pages)
Spectrometry System
Brand:
Waters
| Category:
Measuring Instruments
| Size: 7 MB
Table of Contents
General Information
2
Trademarks
2
Customer Comments
3
Contacting Waters
4
System Manufacturing Information
4
Safety Considerations
5
Considerations Specific to the Device
5
Electrical Power Safety Notice
8
Safety Hazard Symbol Notice
8
Safety Advisories
8
Operating this Device
8
Applicable Symbols
8
Audience and Purpose
9
Intended Use of the Device
9
Calibrating
10
Quality Control
10
EMC Considerations
10
Canada Spectrum Management Emissions Notice
10
ISM Classification: ISM Group 1 Class a
11
EMC Grounding Requirements
11
EC Authorized Representative
11
Table of Contents
12
1 Waters Xevo TQ-XS Overview
19
Intellistart Technology
20
ACQUITY UPLC/MS Xevo TQ-XS Systems
21
ACQUITY UPLC System
21
Waters ACQUITY Xevo TQ-XS UPLC/MS System
21
ACQUITY UPLC M-Class System
22
Non-ACQUITY Devices for Use with the Xevo TQ-XS
22
Software and Data System
23
Ionization Techniques and Source Probes
23
Electrospray Ionization
24
Esci
24
Apci
24
Dual-Mode APPI/APCI Source
24
Unispray
25
Low-Flow ESI Probe
25
Nanoflow ESI Source
25
Atmospheric Solids Analysis Probe (ASAP)
25
Apgc
26
TRIZAIC UPLC Source
26
Ionkey Source
26
Intellistart Fluidics System
26
Overview
26
System Components
28
System Operation
28
Ion Optics
28
MS Operating Modes
29
MS/MS Operating Modes
30
Product (Daughter) Ion Mode
31
Precursor (Parent) Ion Mode
31
MRM Mode
32
Constant Neutral Loss Mode
33
Constant Neutral Gain Mode
33
Scanwave Daughter Scan Mode
33
Leak Sensors
34
Vacuum System
34
Rear Panel
35
2 Preparing the Mass Spectrometer for Operation
37
Preparing to Start the Mass Spectrometer
37
Starting the Mass Spectrometer
38
Verifying the Instrument's State of Readiness
39
Monitoring the Mass Spectrometer Leds
39
Power LED
39
Operate LED
40
Tuning and Calibration Information
40
Running the Mass Spectrometer at High Flow Rates
40
Preparing the Intellistart Fluidics System
41
Installing the Reservoir Bottles
41
Installing the Low-Volume Vials
42
Adjusting the Solvent Delivery Tube Positions
42
Purging the Fluidics
43
Rebooting the Mass Spectrometer
43
Leaving the Mass Spectrometer Ready for Operation
44
Emergency Shutdown of the Mass Spectrometer
45
3 Changing the Mode of Operation
46
ESI, Esci, and APCI Modes
46
ESI Mode
46
Esci Mode
47
APCI Mode
47
Configuring for Esi/Esci/Apci Modes
47
Installing the Probe Adaptor
50
Installing the Probe Assembly
53
Removing the Probe Adaptor
60
Installing and Removing the Corona Pin
61
Combined APPI/APCI Source
65
APPI Operation
65
APCI Operation
66
Dual-Mode Operation
67
The Combined APPI/APCI Source Components
68
Installing the Combined APPI/APCI Source
69
Removing the Combined APPI/APCI Source Enclosure
70
Unispray Source
71
Installing the Unispray Source
73
Removing the Unispray Source
76
Nanoflow ESI Source
77
Installing the Nanoflow Source
77
Fitting a Borosilicate Glass Capillary (Nanovial)
80
Positioning the Borosilicate Glass Capillary Tip
83
Restarting a Stalled Borosilicate Glass Capillary Electrospray
83
Ionkey Source
83
Installing the Ionkey Source
84
Installing Ionkey Source Software
88
Installing the Camera in the Ionkey Source
88
Removing an Ionkey Source
88
4 Maintenance Procedures
91
Maintenance Schedule
91
Spare Parts
93
Troubleshooting with Connections INSIGHT
93
Safety and Handling
94
Preparing the Instrument for Working on the Source
95
Using Masslynx Software to Prepare the Instrument for Operations on or Inside Its Source
95
Removing and Refitting the Source Enclosure
96
Removing the Source Enclosure from the Instrument
96
Fitting the Source Enclosure to the Instrument
98
Operating the Source Isolation Valve
98
Closing the Source Isolation Valve
99
Opening the Source Isolation Valve
100
Removing O-Rings and Seals
100
Cleaning the Instrument Case
101
Emptying the Nitrogen Exhaust Trap Bottle
101
Maintaining the Roughing Pump
103
Cleaning the Source Components
103
Cleaning the Sampling Cone Assembly
103
Removing the Sampling Cone Assembly from the Source
104
Disassembling the Sampling Cone Assembly
105
Cleaning the Sample Cone and Cone Gas Nozzle
108
Assembling the Sampling Cone Assembly
109
Fitting the Sampling Cone Assembly to the Source
110
Cleaning the Ion Block Assembly
111
Removing the Ion Block Assembly from the Source Assembly
111
Disassembling the Source Ion Block Assembly
114
Cleaning the Ion Block Components
118
Assembling the Source Ion Block Assembly
119
Fitting the Ion Block Assembly to the Source Assembly
120
Cleaning the Stepwave Ion Guide Assembly
121
Handling the Stepwave Ion Guide Assembly
121
Removing the Ion Block Support from the Source Assembly
121
Removing the Stepwave Assembly from the Source Assembly
123
Disassembling the Stepwave Ion Guide Assembly
127
Cleaning the Stepwave Ion Guide Assembly
130
Assembling the Stepwave Ion Guide Assembly
132
Fitting the Stepwave Assembly to the Source Assembly
134
Fitting the Ion Block Support to the Source
137
Replacing the Probe Assembly
137
Removing the Probe Assembly
137
Replacing the ESI Probe Tip and Gasket
139
Removing the ESI Probe Tip and Gasket
139
Fitting the ESI Probe Tip and Gasket
141
Cleaning the APCI Probe Tip
142
Replacing the APCI Probe Heater
143
Removing the APCI Probe Heater
143
Fitting the New APCI Probe Heater
144
Cleaning or Replacing the Corona Pin
146
Replacing the Ion Block Source Heater
146
Replacing the Source Assembly Seals
150
Removing the Probe Adjuster Assembly Probe and Source Enclosure Seals
151
Fitting the New Source Enclosure and Probe Adjuster Assembly Probe Seals
153
Replacing the Air Filter Inside the Front Door
154
APPI/APCI Source - Changing the UV Lamp Bulb
156
APPI/APCI Source-Cleaning the Lamp Window
158
APPI/APCI Source - Replacing the APPI Lamp Drive Seals
158
Removing the APPI Lamp Drive Assembly Seals
159
Fitting the New APPI Lamp Drive Assembly O-Rings
163
Replacing the Unispray Probe Assembly
165
Removing the Unispray Probe Assembly
165
Fitting the Unispray Probe Assembly
166
Maintaining the Unispray Impactor Pin
168
Removing and Installing the Unispray Impactor Pin
168
Cleaning or Replacing the Unispray Impactor Pin
169
Replacing the Fluidic Lines of the Ionkey Source
170
Removing a Fluidic Line
171
Installing a Fluidic Line
175
Cleaning the Ionkey Source and Connectors
176
To Remove Buildup from Electronic Connectors
177
To Clean the Outside Surfaces of the Ionkey Source
178
A Safety Advisories
179
Warning Symbols
179
Specific Warnings
180
A.1.1 Specific Warnings
180
Notices
182
Bottles Prohibited Symbol
182
Required Protection
182
A.2 Notices
182
Warnings that Apply to All Waters Instruments and Devices
183
Warnings that Address the Replacing of Fuses
187
Electrical Symbols
188
A.7 Electrical Symbols
188
Handling Symbols
189
A.8 Handling Symbols
189
B External Connections
191
External Wiring and Vacuum Connections
191
Connecting the EBARA Oil-Free Roughing Pump
192
Making the Electrical Connections to the Ebara Oil-Free Roughing Pump
197
Connecting to the Nitrogen Gas Supply
198
Connecting to the Collision Cell Gas Supply
199
Connecting the Nitrogen Exhaust Line
199
Connecting Liquid Waste Lines
201
Connecting the Workstation (Systems with no ACQUITY LC)
204
Connecting to the Workstation
204
Connecting Ethernet Cables (Systems with ACQUITY LC)
204
Input/Output Signal Connectors
205
Connecting to the Electricity Source
207
C Materials of Construction and Compatible Solvents
208
Preventing Contamination
208
Items Exposed to Solvent
208
Solvents Used to Prepare Mobile Phases
209
D Intellistart Fluidics System Plumbing
211
Preventing Contamination
211
Plumbing Schematic
211
Ionkey and TRIZAIC Source Plumbing
212
Tubing Specifications
213
D.4 Tubing Specifications
213
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