Waters Xevo TQ MS Operator's, Overview And Maintenance Manual page 14

Ionization techniques and source probes .................................................... 27
Electrospray ionization (ESI) ............................................................................ 27
Combined electrospray ionization and atmospheric pressure chemical
ionization (ESCi) ................................................................................................ 27
Atmospheric pressure chemical ionization (APCI) .......................................... 27
Dual-mode APPI/APCI source........................................................................... 28
NanoFlow ESI source ........................................................................................ 28
IntelliStart Fluidics system ............................................................................. 29
Overview............................................................................................................. 29
System components ........................................................................................... 30
System operation ............................................................................................... 30
Ion optics .............................................................................................................. 31
MS operating modes .......................................................................................... 32
MS/MS operating modes ................................................................................... 33
Product (daughter) ion mode............................................................................. 34
Precursor (parent) ion mode.............................................................................. 34
Multiple reaction monitoring mode .................................................................. 35
Constant neutral loss mode............................................................................... 36
ScanWave daughter scan mode......................................................................... 37
Leak sensors ........................................................................................................ 38
Vacuum system ................................................................................................... 38
Rear panel ............................................................................................................ 39
2 Preparing the Mass Spectrometer for Operation ............................ 41
Starting the mass spectrometer ..................................................................... 42
Verifying the instrument's state of readiness .................................................. 45
Monitoring the mass spectrometer LEDs......................................................... 45
Tuning and calibration information ................................................................. 45
Running the mass spectrometer at high flow rates ......................................... 46
Preparing the IntelliStart Fluidics system .................................................. 47
Installing the reservoir bottles.......................................................................... 47
Purging the infusion pump................................................................................ 48
xiv February 11, 2013, 71500130002 Rev. D