Waters Xevo TQ-XS IVD Manuals

Manuals and User Guides for Waters Xevo TQ-XS IVD. We have 1 Waters Xevo TQ-XS IVD manual available for free PDF download: Overview And Maintenance Manual

Waters Xevo TQ-XS IVD Overview And Maintenance Manual (142 pages)

Mass Spectrometer

Brand: Waters | Category: Measuring Instruments | Size: 4 MB

General Information
2
Copyright Notice
2
Trademarks
2
Contacting Waters
3
Safety Considerations
3
Considerations Specific to the Device
3
Bottle Placement Prohibition
4
Electrical Power Safety Notice
6
Safety Hazard Symbol Notice
6
Equipment Misuse Notice
7
Safety Advisories
7
Operating the Device
7
Applicable Symbols
7
Audience and Purpose
8
Intended Use
8
Compliance with Medical Device Regulations
9
Calibrating
9
Quality Control for LC-MS/MS Systems
9
EMC Considerations
10
FCC Radiation Emissions Notice
10
ISM Classification: ISM Group 1 Class a
10
EMC Grounding Requirements
11
Manufacturing Information
11
Australian Sponsor Information
11
Table of Contents
12
Waters Xevo TQ-XS IVD Overview
17
Intellistart Technology
17
ACQUITY UPLC I-Class/Xevo TQ-XS IVD System
18
ACQUITY UPLC I-Class IVD System
18
Software and Data System
20
Electrospray Ionization (ESI)
21
Intellistart Fluidics System
21
Overview
21
System Components
22
System Operation
22
Ion Optics
23
MS Operating Modes
24
MS/MS Operating Modes
24
Product (Daughter) Ion Spectrum
25
Precursor (Parent) Ion Spectrum
26
MRM Mode
26
Constant Neutral Loss Mode
27
Constant Neutral Gain Mode
28
Scanwave Daughter Scan Mode
28
Leak Sensors
29
Vacuum System
29
Rear Panel
29
Preparing the Mass Spectrometer for Operation
31
Preparing to Start the Mass Spectrometer
31
Starting the Mass Spectrometer
32
Verifying the Instrument's State of Readiness
33
Monitoring the Mass Spectrometer Leds
33
Power LED
33
Operate LED
33
Tuning and Calibration Information
34
Running the Mass Spectrometer at High Flow Rates
34
Preparing the Intellistart Fluidics System
35
Installing the Reservoir Bottles
35
Required Materials
35
Installing the Low-Volume Vials
36
Adjusting the Solvent Delivery Tube Positions
36
Purging the Fluidics
37
Rebooting the Mass Spectrometer
37
Leaving the Mass Spectrometer Ready for Operation
38
Emergency Shutdown of the Mass Spectrometer
39
Installing and Removing the ESI Probe
40
Installing the Probe Adapter
40
Installing the Probe Assembly
43
Removing the Probe Adapter
49
Maintenance Procedures
51
Maintenance Schedule
51
Spare Parts
52
Preparing the Instrument for Working on the Source
52
Using Masslynx Software to Prepare the Instrument for Operations on or Inside Its Source
52
Removing and Refitting the Source Enclosure
53
Removing the Source Enclosure from the Instrument
53
Fitting the Source Enclosure to the Instrument
54
Operating the Source Isolation Valve
55
Closing the Source Isolation Valve
55
Opening the Source Isolation Valve
56
Removing O-Rings and Seals
57
Cleaning the Instrument Case
58
Emptying the Nitrogen Exhaust Trap Bottle
58
Maintaining the EBARA Oil-Free Roughing Pump
60
Cleaning the Source Components
60
Cleaning the Sampling Cone Assembly
60
Removing the Sampling Cone Assembly from the Source
60
Disassembling the Sampling Cone Assembly
62
Cleaning the Sample Cone and Cone Gas Nozzle
64
Assembling the Sampling Cone Assembly
66
Fitting the Sampling Cone Assembly to the Source
67
Cleaning the Ion Block Assembly
68
Removing the Ion Block Assembly from the Source Assembly
68
Disassembling the Source Ion Block Assembly
70
Cleaning the Ion Block Components
75
Assembling the Source Ion Block Assembly
76
Fitting the Ion Block Assembly to the Source
77
Cleaning the Stepwave Ion Guide Assembly
78
Handling the Stepwave Ion Guide Assembly
78
Removing the Ion Block Support from the Source Assembly
79
Removing the Stepwave Assembly from the Source Assembly
80
Disassembling the Stepwave Ion Guide Assembly
84
Cleaning the Stepwave Ion Guide Assembly
87
Assembling the Stepwave Ion Guide Assembly
89
Fitting the Stepwave Assembly to the Source Assembly
91
Fitting the Ion Block Support to the Source
94
Replacing the Probe Assembly
94
Removing the Probe Assembly
95
Replacing the ESI Probe Tip and Gasket
96
Removing the ESI Probe Tip and Gasket
96
Fitting the ESI Probe Tip and Gasket
98
Replacing the Ion Block Source Heater
99
Replacing the Source Assembly Seals
103
Removing the Probe Adjuster Assembly Probe and Source Enclosure Seals
103
Fitting the New Source Enclosure and Probe Adjuster Assembly Probe Seals
105
Replacing the Air Filter Inside the Front Door
107
A Safety Advisories
109
Warning Symbols
109
Specific Warnings
110
Biohazard Warning
111
Notices
112
Bottles Prohibited Symbol
112
Required Protection
112
Warnings that Apply to All Waters Instruments and Devices
113
Warnings that Address the Replacement of Fuses
117
Electrical Symbols
118
Handling Symbols
119
B External Connections
121
External Wiring and Vacuum Connections
121
Connecting the EBARA Roughing Pump
122
Required Materials
123
Making the Electrical Connections to the Ebara Oil-Free Roughing Pump
126
Connecting to the Nitrogen Gas Supply
127
Connecting to the Collision Cell Gas Supply
128
Connecting the Nitrogen Exhaust Line
129
Connecting Liquid Waste Lines
131
Connecting the Workstation (Systems with no ACQUITY LC)
133
Connecting to the Workstation
133
Connecting Ethernet Cables (Systems with ACQUITY LC)
134
Input/Output Signal Connectors
134
Connecting to the Electricity Source
136
C Materials of Construction and Compatible Solvents
138
Preventing Contamination
138
Items Exposed to Solvent
138
Solvents Used to Prepare Mobile Phases
139
D Intellistart Fluidics System Plumbing
141
Preventing Contamination
141
Plumbing Schematic
141
Tubing Specifications
142

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Waters Xevo TQ-XS IVD Overview And Maintenance Manual (142 pages)

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