Safety Considerations; Considerations Specific To The Xevo Tq-S System - Waters Xevo TQ-S Operator's, Overview And Maintenance Manual

Safety considerations

Some reagents and samples used with Waters instruments and devices can
pose chemical, biological, and radiological hazards. You must know the
potentially hazardous effects of all substances you work with. Always follow
Good Laboratory Practice, and consult your organization's safety
representative for guidance.

Considerations specific to the Xevo TQ-S system

Solvent leakage hazard
The source exhaust system is designed to be robust and leak-tight. Waters
recommends you perform a hazard analysis, assuming a maximum leak into
the laboratory atmosphere of 10% LC eluate.
Flammable solvents hazard
Warning:
the source, maintain a continuous flow of nitrogen through the source
whenever significant amounts of flammable solvents are used during
instrument operation.
Never let the nitrogen supply pressure fall below 400 kPa (4 bar, 58 psi)
during analyses that require flammable solvents. Connect to the LC output
with a gas-fail connector to stop the LC solvent if the nitrogen supply fails.
iv
Warning:
• To confirm the integrity of the source exhaust system, renew
the source O-rings at intervals not exceeding one year.
• To avoid chemical degradation of the source O-rings, which can
withstand exposure only to certain solvents (see
to prepare mobile phases" on page C-3),
solvents you use that are not listed are chemically compatible
with the composition of the O-rings.
To prevent the ignition of accumulated solvent vapors inside
"Solvents used
determine whether any