Precursor (Parent) Ion Mode; Mrm Mode - Waters Xevo TQ-S Operator's, Overview And Maintenance Manual

1 Waters Xevo TQ-S Overview

Precursor (parent) ion mode

Precursor ion mode:
Typical application
You typically use the precursor ion mode for structural elucidation—that is, to
complement or confirm product scan data—by scanning for all the precursors
of a common product ion.

MRM mode

MRM mode is the highly selective MS/MS equivalent of SIR. Because both
MS1 and MS2 are static, greater dwell time on the ions of interest is possible,
so the sensitivity achieved is better, compared with scanning-mode MS/MS.
This mode is the most commonly used acquisition mode for quantitative
analysis, allowing the compound of interest to be isolated from the chemical
background noise.
MRM mode:
Typical application
You typically use MRM mode to quantify known analytes in complex samples:
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MS1
Scanning
MS1
Static (at precursor mass)
Collision cell MS2
Pass all masses Static (at product mass)
Collision cell MS2
Pass all masses Static (at product mass)