Binary Solvent Manager; Column Compartments; Injector Mechanisms - Waters ACQUITY UPLC I-Class System Manual

• Greatly reduced carryover
These advantages provide the following benefits over traditional systems:
• Superior peak capacity
• Higher sensitivity
• Faster data acquisition
• Consistent, reproducible results
The I-Class system is an effective tool for analyzing complex or dilute samples,
providing high resolution and reproducible results for chromatographic
separations.

Binary solvent manager

The ACQUITY UPLC I-Class system employs a binary solvent manager that,
like the system, is optimized for sub-2-μm particle liquid chromatography and
uses reduced fluid volumes. New pressure management capabilities extend
the flow rate envelope for the system to support ballistic gradients. This
support enables you to run higher flow rates and faster cycle times to
accelerate your chromatography, while maintaining the integrity of the
separation.

Column compartments

Column compartments configured with I-Class systems ensure reliable and
robust separations. This is especially important when you transfer methods to
other systems. UPLC applications can benefit from pre-column, mobile-phase
heating to improve chromatographic separations. The ACQUITY UPLC
I-Class column compartments use an active preheater to condition solvent as
it enters the column. The preheater is a heat source that raises the
temperature of the incoming mobile phase and injected sample to the same set
point as that of the column compartment. Active solvent preheaters provide
precise thermal performance with low dispersion for exact control of
chromatographic conditions that remain consistent between systems.

Injector mechanisms

ACQUITY UPLC I-Class system configurations includes a sample manager
with either a fixed-loop or flow-through-needle injector mechanism. This
flexibility allows you to choose the optimum injector mechanism for your
1-4 ACQUITY UPLC I-Class System