B Solvent Considerations; Preventing Contamination; Clean Solvents; Solvent Quality - Waters ACQUITY Arc System System Manual

B
Solvent considerations
This information applies to the ACQUITY Arc system modules.
Warning:
when working with hazardous materials. Consult the Material Safety Data
Sheets regarding the solvents you use. Additionally, consult the safety
representative for your organization regarding its protocols for handling such
materials.
B.1 Preventing contamination
For information explaining how to prevent contamination, refer to Controlling
Contamination in Ultra Performance LC/MS and HPLC/MS Systems (part number
715001307) , available on the Waters Web site. Visit www.waters.com.
B.1.1 Clean solvents
Clean solvents ensure reproducible results and permit you to operate with minimal
instrument maintenance.
Dirty solvents can cause baseline noise and drift, and they can clog solvent reservoir
filters, inlet filters, and capillary lines.
B.1.2 Solvent quality
Use MS-grade solvents for the best possible results; the minimum requirement is
HPLC-grade. Filter solvents through an appropriate membrane filter.
Recommendation:
vendor to ensure that the filter is appropriate for the solvents used.
B.1.3 Solvent preparation
Proper solvent preparation, primarily filtration, can prevent many pumping problems.
Observe Good Laboratory Practice (GLP) at all times, particularly
Heed the recommendations of the filter's manufacturer or
June 12, 2015, 715004747 Rev. A
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