Waters ACQUITY UPLC M-Class System Manual page 56

4 Maintaining the system
ACQUITY UPLC M-Class System troubleshooting: (Continued)
Symptom
Increasing or
decreasing
retention times
(continued)
Broad peaks
56 March 10, 2014, 715003588 Rev. A
Suspected cause
Inlet lines blocked
Mobile phase
contaminated
Fluid leak
Detector time constant or
filter is too high (non-MS
detectors)
MS detector scan rate is
too low
Too much peak smoothing Reduce smoothing to
Possible solution
• Check lines for
blockages, replace
tubing if necessary.
• Clean the solvent inlet
filter frit; replace the
frit if necessary.
Controlling
See also:
Contamination in
UPLC/MS and
HPLC/MS Systems on the
documentation CD.
Refer to the applicable
solvent manager overview
and maintenance guide on
the documentation CD.
The time constant should
be as low as possible and
still minimize baseline
noise.
Increase the scan rate to
obtain more data points
across the peak.
prevent peak shape
distortion.