Waters ACQUITY UPLC M-Class System Manual page 51

The table below summarizes the most common chromatography, method
parameters and sample problems defined at a system-level.
ACQUITY UPLC M-Class System troubleshooting:
Symptom
Baseline or
background
fluctuations
Suspected cause
Solvent contamination
Erratic solvent manager
pressure
Loose fittings or crimped
lines before or after the
column
March 10, 2014, 715003588 Rev. A
Troubleshooting
Possible solution
Use only fresh, clean
solvents.
Controlling
See also:
Contamination in
UPLC/MS and
HPLC/MS Systems on the
documentation CD.
Prime the μBSM and
ASM. If the problem
persists, troubleshoot the
solvent manager pressure.
Inspect all fittings and
tubing. Replace as
necessary.
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