Waters ACQUITY UPLC M-Class System Manual page 47

Solvent manager maintenance procedures: (Continued)
Maintenance
procedure
Replace the in-line
filter
Replace the
accumulator check
valve cartridge
Replace solvent
reservoir filters
Clean the air filter in
the door
Replace the air filter in
the door
Frequency
As needed. The typical failure modes are as follows:
• High back pressure: the in-line filter causes a
high-pressure shutdown. In this case, disconnect
the in-line filter. If the system exhibits pressure
decay, determine the system pressure at known
conditions. Replace the frit or entire check-valve
assembly.
• Leaks: can be detected visibly or by peak
retention times that vary.
As part of the annual scheduled routine
maintenance and thereafter, as needed. The typical
failure modes are as follows:
• Late eluting peaks are exhibited after a dynamic
leak test was performed where the leak rate is
above the acceptable limit.
• The solvent manager exhibits a low or erratic
flow rate or pressure pulsations.
As part of the annual scheduled routine
maintenance and thereafter, as needed. The typical
failure modes are as follows:
• Slow baseline drift is exhibited.
• Retention times are increasing.
• The system exhibits low, erratic, system
pressure.
Perform as part of your annual routine scheduled
maintenance and when solvent or dust
accumulates.
Perform as part of your annual routine scheduled
maintenance and when solvent or dust
accumulates.
March 10, 2014, 715003588 Rev. A
Maintenance procedure and frequency
47