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You dismissed LC and sample-related causes for decreased signal intensity.
If cleaning the sample cone and cone gas nozzles fails to increase signal sensitivity, also clean the
extraction cone. See
If cleaning the extraction cone fails to increase signal sensitivity, clean the ion block and isolation
valve. See
page
If cleaning the ion block and isolation valve fails to increase signal sensitivity, also clean the ion
guide assembly. See
If all these steps fail to increase signal sensitivity, contact Waters Technical Service.
4.18 Cleaning the sampling cone assembly
You can remove the sampling cone assembly (the sample cone, O-ring, and cone gas nozzle) for
cleaning without venting the instrument.
4.18.1
Removing the sampling cone assembly from the source
4.18.1.1
Required material
Chemical-resistant, powder-free gloves
Warning:
To avoid personal contamination with biohazards or toxic materials, and to avoid
spreading contamination to uncontaminated surfaces, wear clean, chemical-resistant, powder-free
gloves when working with the source components.
Warning:
according the procedure on
its source".
Warning:
enclosure open; the ESI probe tip is sharp.
Warning:
open; the source can be hot.
To remove the sampling cone assembly from the source:
1.
Close the source isolation valve (see
page
71.
76.
page
86.
To avoid electric shock, before beginning this procedure, prepare the instrument
page
To avoid puncture wounds, take great care while working with the source
To avoid burn injuries, take great care while working with the source enclosure
September 7, 2016, 715003560IVD Rev. C
44, "To prepare the instrument for operations on or inside
page
47).
Page 64
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