Table of Contents
Advertisement
When analyzing samples from a complex matrix, note that the matrix components can adversely
affect LC/MS results, enhancing or suppressing ionization. To minimize these matrix effects,
Waters recommends you adopt the following measures:
•
Prior to the instrumental analysis, use appropriate sample pretreatment such as protein
precipitation, liquid/liquid extraction (LLE), or solid phase extraction (SPE) to remove matrix
interferences.
•
Verify method accuracy and precision using matrix-matched calibrators and QC samples.
•
Use one or more internal standard compounds, preferably isotopically labeled analytes.
•
To ensure data integrity, Waters recommends you run QC samples before and after test
samples within a single analysis. Additionally, you can periodically run known or PT/EQA
samples as unknowns to verify assay results for a single analysis.
Analytical methods for use in reporting clinical results should be evaluated and validated according
to local regulations and should conform to internationally recognized guidelines, for example,
Clinical and Laboratory Standards Institute guideline C50-A, Mass Spectrometry in the Clinical
Laboratory: General Principles and Guidance; Approved Guideline, C62-A Liquid
Chromatography-Mass Spectrometry Method; Approved Guideline and related documents.
Always follow Good Laboratory Practice (GLP) for method development, method validation, and
quality control.
EMC considerations
Canada spectrum management emissions notice
This class A digital product apparatus complies with Canadian ICES-001.
Cet appareil numérique de la classe A est conforme à la norme NMB-001.
ISM Classification: ISM Group 1 Class A
This classification has been assigned in accordance with CISPR 11 Industrial Scientific and
Medical, (ISM) instrument requirements.
Group 1 products apply to intentionally generated and/or used conductively coupled
radio-frequency energy that is necessary for the internal functioning of the equipment.
Class A products are suitable for use in all establishments other than residential locations and
those directly connected to a low voltage power supply network supplying a building for domestic
purposes.
There may be potential difficulties in ensuring electromagnetic compatibility in other environments
due to conducted as well as radiated disturbances.
Do not use the equipment in close proximity to sources of strong electromagnetic radiation (for
example, unshielded intentional RF sources), as these may interfere with the equipment's proper
operation.
This equipment complies with the emission and immunity requirements described in the relevant
parts of IEC/EN 61326: Electrical equipment for measurement, control and laboratory use — EMC
requirements.
September 7, 2016, 715003560IVD Rev. C
Page xi
Advertisement
Table of Contents
