Waters Xevo TQD Operator's, Overview And Maintenance Manual page 14

NanoFlow source............................................................................................ 1-10
Atmospheric solids analysis probe (ASAP)................................................... 1-10
Atmospheric pressure gas chromatography (APGC) ................................... 1-11
TRIZAIC UPLC source .................................................................................. 1-11
IntelliStart Fluidics system .......................................................................... 1-11
Functionality .................................................................................................. 1-11
System operation ........................................................................................... 1-12
Ion optics ........................................................................................................... 1-13
MS operating modes ....................................................................................... 1-14
MS/MS operating modes ................................................................................ 1-15
Product (daughter) ion mode......................................................................... 1-16
Precursor (parent) ion mode.......................................................................... 1-17
Multiple reaction monitoring mode .............................................................. 1-17
Constant neutral loss mode........................................................................... 1-19
Sample inlet ...................................................................................................... 1-19
Leak sensors ..................................................................................................... 1-20
Vacuum system ................................................................................................ 1-20
Rear panel connections ................................................................................. 1-21
2 Preparing for Operation ...................................................................... 2-1
Starting the mass spectrometer .................................................................... 2-2
Verifying the instrument's state of readiness ................................................ 2-4
Monitoring the instrument LEDs ................................................................... 2-4
Tuning and calibration information ............................................................... 2-4
Running the instrument at different flow rates............................................. 2-5
Preparing the IntelliStart Fluidics system ................................................. 2-6
Installing the reservoir bottles........................................................................ 2-6
Purging the infusion pump.............................................................................. 2-8
Rebooting the instrument ............................................................................... 2-8
Leaving the mass spectrometer ready for operation ............................... 2-9
Emergency shutdown of the mass spectrometer............................................ 2-9
xiv Table of Contents