Waters Positive Pressure-96 Operator's Manual

[ OPERATOR'S GUIDE ]
Waters Positive Pressure-96 Processor
CONT ENT S
I. SYST EM OV E RV IE W
a. Features
II. INSTA L LING T H E WAT E RS P OSIT IV E
P R E SSU R E-96 P ROC E SSO R
a. Installation overview
b. Site requirements
c. Unpacking the processor
d. Installing the processor
III. USING T H E WAT E RS P OSIT IV E
P R E SSU R E-96 P ROC E SSO R
a. Configuring the trays
b. Plate compression
c. Operating the manifold
d. Controlling positive pressure with flow restrictors
e. Adjusting the extraction flow
IV. MAINTAINING T H E WAT E RS P OSIT IV E
P R E SSU R E-96 P ROC E SSO R
a. Maintenance considerations
b. Replacing the 96-place sealing gasket
c. Cleaning the 96-place sealing gasket
d. Storage requirements for the 96-place sealing gasket
e. Cleaning the device's exterior
V. A P P ENDIC E S
a. Safety Advisories
i. Warning symbols
ii. Task-specific hazard warnings
iii. Burst Warning
iv. Caution symbol
v. Warnings that apply to all Waters instruments
vi. Handling symbols
b. Spare Parts
c. Safety considerations
i. Safety advisories
d. Operating this device
i. Applicable symbols
ii. Audience and purpose
iii. Intended use of the Waters Positive
Pressure-96 Processor
I. SYST EM OV E RV IE W
a. Features
The Waters Positive Pressure-96 Processor offers state-of-the-art
operation for solid-phase extraction (SPE), filtration in plates and
1cc flangless cartridges in 96-well formats. Each of the 96 holes in
the processor is restricted in order to maintain constant pressure,
even if all the plate well positions are not filled. Positive pressure
processing offers many advantages over traditional vacuum
manifold processing.
Positive Pressure-96 Processor.
The advantages of positive pressure processing include:
Reproducible analyte recoveries—the manifold gasket with
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96 independent ports provides restricted output of inert gas
at every port. The processor exerts the same motive force to
every port whether it has a full well, dry well or no well access
at all. This provides the most uniform SPE extraction which may
improve the reproducibility of analyte recoveries.
Improved flow for viscous samples—the processor allows for
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gas pressures of 60 to 100 psi (optimal gas pressure is 80 psi),
supplying greater motive force for viscous sample flow.
Adjusting the pressure up or down provides smooth, immediate
flow response and high flow control on variable viscosity
plasma samples in a 96-well plate.
Fits all 96-well plate formats—the processor is self-adjusting
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to plate height, thus accommodating most 96-well plate formats.