Optimizing The Performance Of The Detector; General Guidelines - Thermo Scientific Vanquish VF-D20 Operating Manual

6.7

Optimizing the Performance of the Detector

6.7.1

General Guidelines

Vanquish Charged Aerosol Detectors Operating Manual
This section provides information for best performance of the detector
and gives hints on what you can do to optimize the performance further.
For information on the default parameters, see
Operating Parameters, page
Consider the following guidelines for optimization of the detector
performance:
•
Consider the influences of the parameters on the detection (see
section 6.7.2 Overview of Optimization Parameters, page
• Ensure that the operating conditions are suitable. This includes:
♦
Stable environmental conditions, such as a stable temperature
♦
No air drafts
♦
No vibrations or mechanical shocks caused by external sources
♦
Stable backpressure and correct waste line setup
• Degas the solvent in the Vanquish pump.
•
Monitor the usage of specific detector components that are subject
to wear and stress and schedule appropriate maintenance intervals
(see section 7.4.4 Predictive Performance, page
•
For guidelines and recommendations on the use of mobile phases
with the charged aerosol detector, see
•
Maintain the nitrogen or air source for your detector at regular
intervals to ensure optimum performance. Observe the instructions
in the User Documentation for the nitrogen generator.
•
Use a dedicated column for each specific analysis to avoid cross-
contamination of the column.
•
Do not use a column that has been used with non-volatile mobile
phases.
• Columns that are unstable and/or have a tendency to release
particles from the column bed (i.e. "column bleed") will produce
noise in the detector. Avoid such columns.
section 6.6 Important
100.
section 6.5.1, page
6 • Operation
104).
123).
95.
Page 103