Thermo Scientific Vanquish VF-D20 Operating Manual
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Thermo Scientific Vanquish VF-D20 Operating Manual

Charged aerosol detectors
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thermoscientific
Vanquish
Charged Aerosol
Detectors
VH-D20, VF-D20
Operating Manual 
4820.8401‐EN Revision 2.0a 
 
 
 
• 
September 2017 
 

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  • Page 1         thermoscientific Vanquish Charged Aerosol Detectors VH-D20, VF-D20 Operating Manual  4820.8401‐EN Revision 2.0a  •  September 2017       ...
  • Page 2 Copyright © 2015 Thermo Fisher Scientific Inc. All rights reserved. Trademarks PEEK is a trademark of Victrex PLC. MP35N is a registered trademark of SPS Technologies. Torx is a registered trademark of TEXTRON INDUSTRIES, INC. Acrobat, Adobe, and Adobe Reader are trademarks or registered trademarks of Adobe Systems Incorporated in the United States and other countries.
  • Page 3 Contacting Us Contacting Us There are several ways to contact us: Ordering Information For ordering information or sales support for HPLC products, contact your local Thermo Fisher Scientific sales organization. For contact information, go to Contact Us on http://www.thermoscientific.com. Technical Assistance For technical support for HPLC products, contact your local Thermo Fisher Scientific support organization.
  • Page 4 Contacting Us Page 4 Vanquish Charged Aerosol Detectors Operating Manual...

  • Page 5: Table Of Contents

    Contents Contents 1 Using this Manual ................9 About this Manual ....................10 Conventions ......................11 1.2.1 Safety Messages ..................11 1.2.2 Special Notices and Informational Notes ..........11 1.2.3 Typographical Conventions ..............12 Reference Documentation ..................13 2 Safety ....................15 Safety Symbols and Signal Words .................
  • Page 6 Contents 4 Unpacking and Transport ..............39 Unpacking and Moving ..................40 Scope of Delivery ....................43 5 Installation ..................45 Safety Guidelines for Installation ................. 46 Installing the Detector ..................47 Site Requirements ....................49 Accessing the Interior Components ..............55 Setting Up the Hardware ..................
  • Page 7 Contents Important Operating Parameters ............... 100 Optimizing the Performance of the Detector ............. 103 6.7.1 General Guidelines ................. 103 6.7.2 Overview of Optimization Parameters ..........104 6.7.3 Data Collection Rate and Filter Constant ..........104 6.7.4 Signal Channels ..................106 6.7.5 Evaporation Temperature ..............
  • Page 8 Contents 8 Troubleshooting ................151 General Information about Troubleshooting ............ 152 Messages ......................155 Operating Problems ................... 158 8.3.1 Resolving Leakage ................. 158 8.3.2 Resolving Gas Supply Overpressure ............159 8.3.3 Resolving Flooding In the Detector ............160 8.3.4 Additional Detector Operating Problems ..........161 9 Specifications ................

  • Page 9: Using This Manual

    • Using this Manual 1 Using this Manual This chapter provides information about this manual, the conventions used throughout the manual, and the reference documentation that is available in addition to this manual. Vanquish Charged Aerosol Detectors Operating Manual Page 9...

  • Page 10: About This Manual

    • Using this Manual About this Manual This manual describes the functional features and operating principle of your Vanquish™ detector and provides instructions for installation, set up, start up, shut down, operation, maintenance and troubleshooting. The layout of this manual is designed to provide quick reference to the sections of interest to the user.

  • Page 11: Conventions

    • Using this Manual Conventions This section describes the conventions that are used throughout this manual. 1.2.1 Safety Messages The safety messages and precautionary statements in this manual appear as follows: • Safety messages or precautionary statements that apply to the entire manual and all procedures in this manual are grouped in the Safety chapter.

  • Page 12: Typographical Conventions

    • Using this Manual 1.2.3 Typographical Conventions These typographical conventions apply to the descriptions in this manual: Data Input and Output • The following appears in bold type: ♦ Input that you enter by the keyboard or that you select with the mouse ♦...

  • Page 13: Reference Documentation

    • Using this Manual Reference Documentation In addition to this operating manual, other documentation is available for reference. Hardware Documentation Additional hardware documentation includes the following: • Operating manuals for the other modules of the Vanquish system A printed version of the manual is shipped with the device. •...
  • Page 14 • Using this Manual Chromeleon™ 6.8 Help • The Chromeleon 6.8 Help provides extensive information for all aspects of the software, including device installation and configuration. TIP The Chromeleon Help and documents are included in the software shipment. Third-Party Documentation Refer also to the user documentation provided by the manufacturers of third-party components and materials, for example, Safety Data Sheets (SDSs).

  • Page 15: Safety

    • Safety 2 Safety This chapter provides general and specific safety information and informs about the intended use of the detector. Vanquish Charged Aerosol Detectors Operating Manual Page 15...

  • Page 16: Safety Symbols And Signal Words

    • Safety Safety Symbols and Signal Words 2.1.1 Safety Symbols and Signal Words in This Manual This manual contains safety messages to prevent injury of the persons using the detector. The safety symbols and signal words in this manual include the following: Always be aware of the safety information.

  • Page 17: Observing This Manual

    • Safety 2.1.2 Observing this Manual Observe the following: • Before installing or operating the detector, read this manual carefully to be familiar with the detector and this manual. The manual contains important information with regard to user safety as well as use and care of the detector.

  • Page 18: Intended Use

    • Safety Intended Use The detector is intended to be part of the Vanquish system. The intended use of the Vanquish system is to analyze a mixture of compounds in sample solutions. The detector is for use by qualified personnel and in laboratory environment only. The detector and Vanquish system are intended for laboratory research use only.

  • Page 19: Safety Precautions

    • Safety Safety Precautions 2.3.1 General Safety Information All users must observe the general safety information presented in this section and all specific safety messages and precautionary statements elsewhere in this manual during all phases of installation, operation, troubleshooting, maintenance, shutdown, and transport of the detector. If the detector is used in a manner not specified by Thermo Fisher Scientific, the protection provided by the detector could be impaired.

  • Page 20: Qualification Of The Personnel

    • Safety 2.3.2 Qualification of the Personnel Observe the information below on the proper qualification of the personnel installing and/or operating the detector. Installation Only skilled personnel are permitted to install the detector and to establish the electrical connections according to the appropriate regulations.

  • Page 21: Electrical Safety Precautions

    • Safety Protective Eyewear To prevent liquids from striking your eyes, put on appropriate protective eyewear, such as safety glasses with side shields. If there is a risk of splashing liquids, put on goggles. Gloves To protect you from harmful liquids and avoid personal injury during maintenance or service, put on appropriate protective gloves.

  • Page 22: General Residual Hazards

    • Safety 2.3.5 General Residual Hazards Pay attention to the following general residual hazards when working with the detector: WARNING—Hazardous Substances Solvents, mobile phases, samples, and reagents might contain toxic, carcinogenic, mutagenic, infectious, or otherwise harmful substances. The handling of these substances can pose health and safety risks. •...
  • Page 23 • Safety WARNING—Self-Ignition of Solvents Solvents with a self-ignition temperature below 150 °C might ignite when in contact with a hot surface (for example, due to leakage in the chromatography system). Avoid the use of these solvents. WARNING—Hazardous Gases Mobile phases and samples might contain volatile or flammable solvents.

  • Page 24: In Case Of Emergency

    • Safety CAUTION—Sparking due to Electrostatic Discharge Liquid flowing through capillaries can generate static electricity. This effect is particularly present with insulating capillaries and non- conductive solvents (for example, pure acetonitrile). Discharge of electrostatic energy might lead to sparking, which could constitute a fire hazard.

  • Page 25: Solvent And Additive Information

    • Safety Solvent and Additive Information To protect optimal functionality of the Vanquish system, observe these recommendations on the use of solvents and additives: • The system must be used with reversed-phase (RP) compatible solvents and additives only. TIP The Vanquish charged aerosol detector can also be used with normal-phase (NP) compatible solvents and additives if the other modules in the Vanquish system are compatible for normal-phase applications.
  • Page 26 • Safety • Follow any specific recommendations presented in other sections of this manual. Refer also to the operating manuals for all modules in the Vanquish system. They may provide additional guidelines and information. Page 26 Vanquish Charged Aerosol Detectors Operating Manual...

  • Page 27: Compliance Information

    • Safety Compliance Information Thermo Fisher Scientific performs complete testing and evaluation of its products to ensure full compliance with applicable domestic and international regulations. When the device is delivered to you, it meets all pertinent electromagnetic compatibility (EMC) and safety standards as described in this manual.
  • Page 28 • Safety Page 28 Vanquish Charged Aerosol Detectors Operating Manual...

  • Page 29: Detector Overview

    • Detector Overview 3 Detector Overview This chapter introduces you to the detector and the main components. Vanquish Charged Aerosol Detectors Operating Manual Page 29...

  • Page 30: Detector Features

    • Detector Overview Detector Features The detector comprises the following main features: • Charged aerosol detection method for liquid chromatography for detection of all non-volatile and many semi-volatile analytes • Detection based on measuring charge that is proportional to the amount of analyte, and, for non-volatile analytes, independent of the chemical structure of the analyte In comparison to UV detection, a chromophore is not required for...

  • Page 31: Operating Principle

    • Detector Overview Operating Principle The detector is designed for charged aerosol detection with full compatibility in HPLC and UHPLC applications. In charged aerosol detection, an aerosol of dried analyte particles is formed after nebulization of column eluate. Electrical charge is imparted to these dried particles.
  • Page 32 • Detector Overview The largest aerosol droplets condense within the spray chamber (no. 5) and are removed by the drain pump (no. 6) through the waste outlet. Smaller droplets pass into a temperature-controlled evaporation tube (no. 7), in which solvent and more volatile components are vaporized. By the end of the evaporation tube, the resulting aerosol particles enter the mixing chamber (no.

  • Page 33: Interior Components

    • Detector Overview Interior Components The user-accessible components of the detector are located directly behind the front doors: Figure 2: Interior view Description Keypad with status indicators Gas filter assembly behind the protective cover Leak tray Nebulizer (after installation) Waste outlet Type label, indicating the part number, module name, and serial number Drain port Leak sensor...

  • Page 34: Nebulizer

    • Detector Overview Nebulizer The FocusJet nebulizer is the liquid flow inlet of the charged aerosol detector. Eluate from the column flows into the nebulizer and merges with filtered gas that is supplied to the nebulizer. Due to the concentric flow design of the nebulizer, an aerosol is produced within the spray chamber.

  • Page 35: Gas Filter Assembly

    • Detector Overview Gas Filter Assembly An assembly of two gas filters on the front side of the detector filters the supplied gas internally before it is used in the detector. The gas filters consist of a charcoal filter and a high-efficiency particulate air (HEPA) filter.

  • Page 36: Excess Liquid And Leak Detection

    • Detector Overview Excess Liquid and Leak Detection As leaks are a potential safety issue, sensors in the charged aerosol detector monitor the following: • Excess liquid inside the detector gas flow path The liquid sensor inside the detector detects any liquid that accumulates inside.

  • Page 37: Operation

    • Detector Overview Operation The detector is designed to be operated from a computer configured with the Chromeleon Chromatography Data System (CDS). The Chromeleon software provides complete instrument control, data acquisition, and data management. For a basic description of instrument control and automated sample analysis with the Chromeleon software, refer to the Vanquish System Operating Manual.
  • Page 38 • Detector Overview Page 38 Vanquish Charged Aerosol Detectors Operating Manual...

  • Page 39: Unpacking And Transport

    • Unpacking and Transport 4 Unpacking and Transport This chapter provides information for unpacking and moving the detector and informs you about the scope of delivery. Vanquish Charged Aerosol Detectors Operating Manual Page 39...

  • Page 40: Unpacking And Moving

    • Unpacking and Transport Unpacking and Moving Damaged Packaging, Defective on Arrival Inspect the shipping container for signs of external damage and, after unpacking, inspect the detector for any signs of mechanical damage that might have occurred during shipment. If you suspect that the detector may have been damaged during shipment, immediately notify the incoming carrier and Thermo Fisher Scientific about the damage.
  • Page 41 • Unpacking and Transport 4. Grasp the detector by the carrying handles. Slowly and carefully, lift the detector out of the shipping container. If the foam spacer under the detector is lifted out of the shipping container with the detector, remove it from the detector before you continue.
  • Page 42 • Unpacking and Transport 9. Some surfaces including the doors of the detector are covered by a protective film during shipment. Remove the protective film from all surfaces as applicable. Moving the Detector after Installation If you have to move the detector after it has been set up and installed in the Vanquish system, prepare the detector for transport and move it to the new location.

  • Page 43: Scope Of Delivery

    • Unpacking and Transport Scope of Delivery The following items are included in the delivery: • Detector with nebulizer • Ship Kit For details about the kit content, see section 10.2 Ship Kit, page 169. • Operating manual • Power cord Vanquish Charged Aerosol Detectors Operating Manual Page 43...
  • Page 44 • Unpacking and Transport Page 44 Vanquish Charged Aerosol Detectors Operating Manual...

  • Page 45: Installation

    • Installation 5 Installation This chapter specifies the requirements for the installation site and describes how to set up, install, and configure the detector in the Vanquish system and in the chromatography software. Vanquish Charged Aerosol Detectors Operating Manual Page 45...

  • Page 46: Safety Guidelines For Installation

    • Installation Safety Guidelines for Installation Pay attention to the following safety guidelines: Observe all warning messages and precautionary statements presented section 2.3 Safety Precautions (see page 19). CAUTION—Heavy Load, Bulky Device The detector is too heavy or bulky for one person alone to handle safely. To avoid personal injury or damage to the detector, observe the following guidelines: •...

  • Page 47: Installing The Detector

    • Installation Installing the Detector The Vanquish system is installed and set up by a Thermo Fisher Scientific service engineer, including all modules and options or parts shipped with them. The service engineer checks that the installation is correct and that the Vanquish system and modules operate as specified.
  • Page 48 • Installation 6. Recommended: Perform Instrument Installation Qualification. In Chromeleon, a wizard is available to guide you through the qualification process: ♦ On the Chromeleon 7 Console: Click Tools > Instrument Qualification > Installation Qualification. ♦ In the Chromeleon 6.8 Browser: Click Qualification > Instruments IQ.

  • Page 49: Site Requirements

    • Installation Site Requirements The operating environment is important to ensure optimal performance of the detector. This section provides important requirements for the installation site. Note the following: • Operate the detector only under appropriate laboratory conditions. • The detector is intended to be part of the Vanquish system. Observe the site requirements for the Vanquish system as stated in the Vanquish System Operating Manual.
  • Page 50 • Installation Power Cord The power cords are designed to match the wall socket requirements of the country in which they are used. The end of the power cords that plugs into the power socket on the device is identical for all power cords. The end of the power cords that plugs into the wall socket is different.
  • Page 51 • Installation Ventilation CAUTION—Hazardous Fumes The exhaust gas of the detector may contain hazardous fumes that pose health and safety risks. Avoid an accumulation of gas. The exhaust gas must always be removed by proper ventilation. Make sure that the installation site is well ventilated.
  • Page 52 • Installation Gas Supply CAUTION—Explosion Hazard or Damage to the Detector When using tetrahydrofuran (THF), the use of air as supplied gas may pose an explosion hazard. This can pose a safety and health risk and damage the detector. Always use nitrogen with tetrahydrofuran or other highly combustible solvents.
  • Page 53 • Installation NOTICE—Gas Specifications The requirements and specifications for the gas supplied to the detector have major impact on the detector performance. Observe the following notes: • If the gas supply pressure is varying or dropping below the specified pressure range, it can impair the performance of the detector or even damage the detector.
  • Page 54 • Installation • The use of a non-bottled gas source is recommended, such as ♦ A nitrogen generator with suitable air compressor or with a suitable in-house air source ♦ Medical-grade nitrogen from an in-house liquid nitrogen source TIP Use of smaller compressed nitrogen cylinders or liquid nitrogen containers may be a quick and easy source of nitrogen during installation.

  • Page 55: Accessing The Interior Components

    • Installation Accessing the Interior Components To access the interior components in the detector, open the front doors. To allow easy access from the front, the user-accessible components and flow connections in the detector are located directly behind the doors. Figure 7: Opening the front doors Vanquish Charged Aerosol Detectors Operating Manual Page 55...

  • Page 56: Setting Up The Hardware

    • Installation Setting Up the Hardware This section describes how to set up the hardware and provides information about the detector connectors and cables. 5.5.1 System Arrangement The detector is part of the Vanquish system. The system modules are typically arranged in a system stack, with the arrangement depending on the system configuration.
  • Page 57 • Installation Follow these steps Depending on the system configuration, follow the steps as required: • If the charged aerosol detector is the only detector in the Vanquish system Follow the instructions in the Vanquish System Operating Manual to set up the system stack. •...

  • Page 58: Connecting The Detector

    • Installation 5.5.2 Connecting the Detector Detector Connectors The following connectors are provided on the detector: Figure 9: Electrical and gas connectors on the right side of the detector Description Main power switch (on/off control) Fuse holder Power-inlet connector Page 58 Vanquish Charged Aerosol Detectors Operating Manual...
  • Page 59 • Installation Description System Interlink port Allows power on/off control for the detector from the Vanquish system base and additional device communication and synchronization between the autosampler and the detector In addition, the connection provides device communication between the charged aerosol detector and the pump. For example, certain problems in the charged aerosol detector cause an automatic stop of the pump flow to prevent a build-up of excess liquid inside the detector.
  • Page 60 • Installation 2. Connect the required interface cables to the detector. If the charged aerosol detector is the only detector in the ♦ Vanquish system Follow the instructions in the Vanquish System Operating Manual to set up the USB and system interlink connections in the system.
  • Page 61 • Installation Description System base Pump Sampler Diode array detector Charged aerosol detector Column compartment Connection to computer Figure 10: Interface cable connections in the Vanquish system with charged aerosol detector and diode array detector 3. Verify that the power switch on the detector is set to OFF. 4.

  • Page 62: Installing The Nebulizer

    • Installation 5. Connect the free end of the power cord to an appropriate power source. 5.5.3 Installing the Nebulizer This section describes the installation of the FocusJet nebulizer. CAUTION—Sharp Tip of Nebulizer Capillary The fused-silica capillary inside the nebulizer protrudes from the nebulizer tip.
  • Page 63 • Installation Preparations 1. Wear clean-room gloves. 2. Remove the packed nebulizer from behind the detector doors. 3. Unpack the nebulizer carefully from the packaging. Locate the gas pressure certificate for the nebulizer. Keep the nebulizer packaging to have it available when transporting the nebulizer.
  • Page 64 • Installation Follow these steps 1. On the front of the detector, remove the dust seal plug from the opening for the nebulizer. Keep the dust seal plug to have it available when transporting the detector. Figure 13: Dust seal plug installed in the nebulizer opening 2.
  • Page 65 • Installation ♦ Mind the correct orientation of the nebulizer: The gripping sides of the nebulizer are on the top and bottom side of the handle. The protruding sides for attachment are on the left and right side of the handle. See the picture below. Description Opening in the middle of the nebulizer opening...
  • Page 66 • Installation 4. Turn the nebulizer by 90 degrees clockwise in the opening to lock the nebulizer. Check that the protruding sides on the nebulizer arrest behind the two locks of the opening and lie against the alignment pin. Figure 16: Locking the nebulizer in the detector Description Locks on the nebulizer opening Alignment pin...

  • Page 67: Connecting The Gas Inlet And Exhaust Tubes

    • Installation 5.5.4 Connecting the Gas Inlet and Exhaust Tubes This section describes the connection of the gas inlet and exhaust tubes to the detector. Parts required • Gas supply • Ventilation appliance • Parts for connecting the gas supply: ♦...
  • Page 68 • Installation 2. Connect the gas exhaust tubing to the ventilation and route it to the detector. 3. Check the length of the gas tubes. The gas tubes should go straight to the detector. If the gas tubes are longer than required, use a tubing cutter to cut the tubes straight to the required length.
  • Page 69 • Installation 5. On the right side of the detector, connect the elbow connectors: a) On the left port (gas inlet), push the connection stem of the gas inlet elbow connector (no. 2) into the port (no. 1). b) On the right port (gas exhaust), push the connection stem of the gas exhaust elbow connector (no.

  • Page 70: Setting Up The Liquid Flow Connections

    • Installation Setting Up the Liquid Flow Connections 5.6.1 General Information and Guidelines This section describes how to set up the flow connections to and from the detector and additional flow connections if required. When setting up flow connections, follow these rules and recommendations: Flow connections can be filled with hazardous substances.

  • Page 71: Guiding Capillaries And Tubing Through The System

    • Installation Follow these steps To set up the liquid flow connections and complete the installation of the detector, follow these steps: 1. Connect the waste line (see section 5.6.4, page 75). 2. Connect the inlet capillary to the nebulizer (see section 5.6.5, page 76).
  • Page 72 • Installation In each module, push the tube (or capillary) into the appropriate guide (see picture). Figure 19: Tubing chase with tubing guides (left: view from inside, right: view from top) Use for Solvent tubing (up to three solvent lines, preferably routed to the upper degas chambers) Solvent tubing (up to three solvent lines) Wash liquid tubing (seal wash, autosampler needle wash)

  • Page 73: Connecting Fittings, Capillaries, And Tubing

    • Installation 5.6.3 Connecting Fittings, Capillaries, and Tubing This section provides information about how to connect and handle capillaries, fittings, and tubing. General Guidelines 5.6.3.1 When connecting capillaries and tubing, follow these general recommendations: • Use only the capillaries and tubing (for example, solvent lines or waste tubing) that are shipped with the detector or additional or spare capillaries and tubing as recommended by Thermo Fisher Scientific.
  • Page 74 • Installation Description Knurl Capillary Slot Figure 21: Viper fitting with knurl 1. Insert the Viper capillary into the connection port. 2. Tighten the connection by the knurl. TIP Note the slot in the knurl. For narrow connections, you can easily remove the knurls from neighboring capillaries through this slot and attach them again later.

  • Page 75: Connecting The Waste Line

    • Installation 5.6.4 Connecting the Waste Line NOTICE Extending or combining the waste line can cause a backpressure in the line that can lead to an excess liquid build-up inside the detector. Avoid extending or combining the waste line. Make sure that the waste line drains freely into waste.

  • Page 76: Connecting The Inlet Capillary To The Nebulizer

    • Installation 3. Check the waste line over the entire flow path: a) Make sure that no bending, pinching or squeezing of the waste line is present at any point in the flow path. b) If you have to cut tubing to length, use a tubing cutter. Make sure that the cut is at right angle to the length of the line.
  • Page 77 • Installation Follow these steps Route and connect the capillary to the nebulizer as required by the system arrangement: • Connecting the capillary between column and nebulizer (see section 5.6.5.1, page –or– • Connecting the capillary between flow cell and nebulizer (see section 5.6.5.2, page Follow the respective instructions.
  • Page 78 • Installation Connecting the Capillary Between Flow Cell and Nebulizer 5.6.5.2 If the charged aerosol detector is the second detector in the Vanquish system flow path, for example after the diode array detector, connect the capillary between flow cell and nebulizer. Observe the following guidelines for series flow configuration: •...
  • Page 79 • Installation 3. On the leak tray of the charged aerosol detector, route the capillary through the capillary clip and secure it behind the clip. a) Pull the capillary clip carefully to the right to open the clip. b) Position the capillary behind the capillary clip. c) Carefully release the clip and take care not to clamp the capillary.

  • Page 80: Guiding Liquid Leaks To Waste

    • Installation Description Capillary connection from the column compartment to the flow cell Capillary connection between flow cell and nebulizer Waste line from the charged aerosol detector to the system base 5.6.6 Guiding Liquid Leaks to Waste Leaking liquids of the detector are collected in the leak tray, where they flow off through the chase on the right side of the leak tray to the drain system.

  • Page 81: Turning On The Detector

    • Installation Turning On the Detector TIP Before turning on the power to a Vanquish system module for the first time, verify that the chromatography software is installed on the data system computer. When the power is turned on, the required USB drivers are automatically found and the Windows®...

  • Page 82: Setting Up The Detector In The Software

    • Installation Setting Up the Detector in the Software This manual assumes that the chromatography software is already installed on the data system computer and a valid license is available. For more information about setting up the Vanquish system in the software, refer to the Vanquish System Operating Manual.

  • Page 83: Operation

    • Operation 6 Operation This chapter describes the elements for detector control, provides information for routine operation and for shutdown. Vanquish Charged Aerosol Detectors Operating Manual Page 83...

  • Page 84: Introduction To This Chapter

    • Operation Introduction to this Chapter The information in this chapter assumes that the initial setup of the detector has already been completed. If this is not the case, refer to the instructions in chapter 5 Installation before proceeding (see page 45).

  • Page 85: Safety Guidelines For Operation

    • Operation Safety Guidelines for Operation When operating the detector, pay attention to the following safety guidelines: Observe all warning messages and precautionary statements presented section 2.3 Safety Precautions (see page 19). CAUTION—Explosion Hazard or Damage to the Detector When using tetrahydrofuran (THF), the use of air as supplied gas may pose an explosion hazard.
  • Page 86 • Operation • Turn on the gas supply and detector gas flow only when the nebulizer is installed, the components in the gas flow path are properly connected, and the protective cover of the gas filter assembly is installed. • Observe the requirements for gas supply and ventilation.

  • Page 87: Control Elements

    • Operation Control Elements The detector is designed to be operated mainly from a computer running with the chromatography software. In addition, the following elements are available on the detector: • Keypad The keypad buttons allow you to perform certain functions directly from the detector.
  • Page 88 • Operation MUTE ALARM If beeping alerts you that the detector firmware detected a problem, for example leakage, beeping continues until you turn off the beep. Pressing this button turns off the beep for the current alarm. As a standard, beeping starts again after 10 minutes if the problem is still present or if the firmware detected another problem.

  • Page 89: Status Indicators

    • Operation 6.3.2 Status Indicators The status LED bar on the front side of the detector and the STATUS LED on the inside keypad provide information about the detector status. LED Bar The LED bar provides the information when the detector is closed. When the detector is connected in the Chromeleon software, the LED bar may provide less information.
  • Page 90 • Operation STATUS LED The STATUS LED in the detector provides the following information: STATUS LED Description Off (dark) The power to the detector is turned off. Green The detector is functioning properly. A problem or error has occurred. For the related message, check the Chromeleon Audit Trail.

  • Page 91: Power On/Off Control

    • Operation Power On/Off Control The power switch on the detector is the main switch for power on/off control. The main power switch is turned on during initial installation of the detector. For easier handling, you can use the power button on the front left of the Vanquish system base (system power button) for power on/off.

  • Page 92: Preparing The Detector For Operation

    • Operation Preparing the Detector for Operation This section gives information on any additional steps that are required to prepare the detector for operation and sample analysis. Before Operating the Detector for the First Time Prepare the detector for the first-time operation, observing the following: NOTICE Flush the system flow path thoroughly before operating the detector for the first time:...
  • Page 93 • Operation Before Starting Sample Analysis Before starting an analysis: • Make sure that the pump flow rate that is delivered to the charged aerosol detector is within the specified range. See section 9.1, page 164. • To deliver pump flow to the charged aerosol detector, follow these steps: a) Turn on the detector gas flow.
  • Page 94 • Operation ♦ Monitoring the detector signal and checking whether the detector signal is stable so that the drift and signal noise are within reasonable limits for the application ♦ Performing an autozero of the detector baseline TIP The Chromeleon software supports procedures for automatically starting a chromatography system in the software (Smart Startup).

  • Page 95: Mobile Phase Guidelines For The Detector

    • Operation 6.5.1 Mobile Phase Guidelines for the Detector CAUTION—Explosion Hazard or Damage to the Detector When using tetrahydrofuran (THF), the use of air as supplied gas may pose an explosion hazard. This can pose a safety and health risk and damage the detector.
  • Page 96 • Operation • Avoid filtering the mobile phase. Filtration can increase the amount of detectable particulates within the mobile phase. • With highly combustible mobile phases, such as tetrahydrofuran (THF) and other ethers and ketones, use nitrogen as supply gas. •...
  • Page 97 • Operation • Use the lowest practical concentration of additive, especially those that typically have higher residue after evaporation, such as trifluoroacetic acid (TFA) and heptafluorobutyric acid (HFBA). • Avoid using non-volatile buffers, such as those based on sulfate and phosphate.

  • Page 98: Verifying The Nebulizer Gas Pressure

    • Operation 6.5.2 Verifying the Nebulizer Gas Pressure Before operating the detector, verify the nebulizer gas pressure setting. NOTICE Operating the nebulizer with a gas pressure other than the pressure specified for this nebulizer can damage the nebulizer and the detector.

  • Page 99: Turning On The Detector Gas Flow

    • Operation 6.5.3 Turning On the Detector Gas Flow Follow the instructions in this section to turn on the detector gas flow. CAUTION—Escaping Gas Gas can escape from open gas connections when the detector gas flow and/or the gas supply is turned on. The escaping gas can pose a health and safety risk.

  • Page 100: Important Operating Parameters

    • Operation Important Operating Parameters The parameters described in this section should be considered for routine operation of the detector. You can usually access these parameters from the Chromeleon user interface. For more information, refer to Chromeleon Help and documents. Parameters Description Signal channels...
  • Page 101 • Operation Parameters Description Gas regulator pressure The default unit setting for the gas pressure corresponds to the Pressure Unit that is defined on the detector configuration pages in the Chromeleon software. Gas regulator Specifies the nebulizer gas pressure as specified on the pressure nominal certificate that was shipped with the nebulizer.
  • Page 102 • Operation Parameters Description Evaporator temperature Temperature control for the evaporation tube is enabled control as a standard when the detector is shipped. Evaporator Specifies the setpoint for the evaporation temperature. temperature nominal As a standard, the Evaporator Temperature Nominal is set to 35 °C.

  • Page 103: Optimizing The Performance Of The Detector

    • Operation Optimizing the Performance of the Detector This section provides information for best performance of the detector and gives hints on what you can do to optimize the performance further. For information on the default parameters, see section 6.6 Important Operating Parameters, page 100.

  • Page 104: Overview Of Optimization Parameters

    • Operation • When the mobile phase was stored over a period of time, high background current may be observed. Replace old mobile phase with freshly prepared mobile phase. • If you use the detector for the analysis of complex biological samples, proper sample preparation is especially important.
  • Page 105 • Operation When you select a data collection rate, observe the following guidelines: • In general, each peak should be defined by at least 20 data points. For chromatograms with co-eluting peaks or low signal-to-noise ratios, 40 data points per peak are recommended. •...

  • Page 106: Signal Channels

    • Operation 6.7.4 Signal Channels The following signal channels are available for the detector: • CAD_1 The signal channel is available for data acquisition. • Background current The signal channel displays the background current of the detector during data acquisition without autozero or filter constant applied. It is recommended to always record the background current signal channel.

  • Page 107: Evaporation Temperature

    • Operation 6.7.5 Evaporation Temperature The temperature-controlled evaporation tube dries the aerosol droplets that come from the spray chamber. The evaporation tube evaporates the more volatile components in the mobile phase to produce dried particles composed of non-volatile analyte and background residue. The efficiency of the drying procedure depends on the set temperature.
  • Page 108 • Operation Guidelines for selecting the evaporation temperature The following guidelines are recommended for selecting an optimal evaporation temperature: • In general, use the lowest evaporation temperature within the specified temperature range that provides acceptable limits of sensitivity. • As a starting point, use an evaporation temperature of 35 °C. •...

  • Page 109: Gas Regulation Mode (Vh-Detector Only)

    • Operation 6.7.6 Gas Regulation Mode (VH-Detector only) This section applies only to the VH-detector. The detector provides two gas regulation modes to optimize the efficiency of the nebulizer: Analytical mode and MicroLC mode. Each mode sets a specific nebulizer gas pressure for the analysis, based on the gas pressure specified for the nebulizer from the nebulizer certificate.

  • Page 110: Baseline Noise

    • Operation The transformation is applied to the data output in real time. The data output is raised to the selected power. As a standard, the Power Function is set to 1.0. For most applications and compounds, this is a good universal setting. Guidelines for selecting a power function value To optimize the power function value, observe the following guidelines: •...

  • Page 111: Shutting Down The Detector

    • Operation Shutting Down the Detector If the detector will not be operated for some time, follow the instructions on shutting down the detector in this section. TIP The Chromeleon software provides procedures for automatically preparing the chromatography system for shutdown. The procedures include, for example, operations for reducing the flow rate, reducing the temperature in temperature-controlled devices, and turning off the detector lamps.

  • Page 112: Long-Term Shutdown

    • Operation 6.8.2 Long-Term Shutdown Shutting Down the Detector NOTICE Observe the following to avoid damage to the charged aerosol detector: • Always flush the detector with an appropriate pure solvent before interrupting operation. Follow the steps below. • Avoid leaving the detector exposed to highly acidic or basic mobile phases for long periods.
  • Page 113 • Operation ♦ Detector shall be transported or shipped after shutdown ♦ If no buffer solution is used, flush the system with isopropanol. ♦ If a buffer solution is used, flush the system first with several volumes (for example, 1.0 mL/min for 10 minutes with the standard system) of methanol and water (50:50) to prevent salt buildup in the fluidics.
  • Page 114 • Operation Restarting the Detector To restart the detector, follow these steps: 1. Prepare and restart the other modules in the Vanquish system, following the instructions in the Operating Manuals for the modules. Pay special attention to the Preparing the Module for Operation section.

  • Page 115: Maintenance And Service

    • Maintenance and Service 7 Maintenance and Service This chapter describes the routine maintenance and the service procedures that the user may perform. Vanquish Charged Aerosol Detectors Operating Manual Page 115...

  • Page 116: Introduction To Maintenance And Service

    • Maintenance and Service Introduction to Maintenance and Service This chapter describes the routine maintenance and service and repair procedures that the user may perform. Additional maintenance or service procedures must be performed only by service personnel certified by Thermo Fisher Scientific (for brevity, referred to as Thermo Fisher Scientific service personnel).

  • Page 117: Safety Guidelines For Maintenance And Service

    • Maintenance and Service Safety Guidelines for Maintenance and Service When performing maintenance or service procedures, pay attention to the following safety guidelines: Observe all warning messages and precautionary statements presented section 2.3 Safety Precautions, page WARNING—High Voltage High voltages are present inside the detector that could cause an electric shock.
  • Page 118 • Maintenance and Service CAUTION—Hydrostatic Pressure Solvent may spill when you open the flow path during pump operation. This is due to hydrostatic pressure in the system when the solvent reservoirs are located above the pump outlet. Before you loosen a connection in the low-pressure flow path, turn off the pump flow and wait until the system pressure is down to zero.

  • Page 119: General Rules For Maintenance And Service

    • Maintenance and Service General Rules for Maintenance and Service For successful maintenance and service procedures, follow these rules and recommendations: • Before starting maintenance or service procedures, shut down the detector when instructed to do so. • Use only the replacement parts specifically authorized and qualified for the detector by Thermo Fisher Scientific.

  • Page 120: Routine And Preventive Maintenance

    • Maintenance and Service Routine and Preventive Maintenance Optimum detector performance, maximum uptime of the detector, and accurate results can be obtained only if the detector is in good condition and properly maintained. 7.4.1 Maintenance Plan Perform the maintenance procedures in the table on a regular basis. The frequency given in the table is a suggestion.

  • Page 121: Flushing The Detector Between Analyses

    • Maintenance and Service 7.4.2 Flushing the Detector Between Analyses Observe the following guidelines to prevent build-up or accumulation of residue from the mobile phase, sample matrix and analytes within the detector between the analyses. This helps maintain consistent response, optimum performance and reduced detector downtime: •...
  • Page 122 • Maintenance and Service Parts required • Suitable cleaning detergent (or disinfectant) • Purified water • Lint-free cloths or wipes CAUTION—Explosive Gas Mixtures from Alcoholic Cleaning Detergents Alcohol-containing cleaning detergents may form flammable and explosive gas mixtures when exposed to air. •...

  • Page 123: Predictive Performance

    • Maintenance and Service Follow these steps 1. Wipe the surfaces clean with a clean, dry, soft, lint-free cloth or wipe. If necessary, slightly dampen the cloth or wipe with a solution of lukewarm water and a suitable cleaning detergent. 2.
  • Page 124 • Maintenance and Service The list shows the most important Predictive Performance counters for the detector. Consider resetting these parameters after performing the related maintenance procedure: • FilterDone If you have replaced the gas filter assembly, consider resetting this counter after replacement of the gas filter assembly. •...

  • Page 125: Disconnecting The Gas Inlet And Exhaust Tubes

    • Maintenance and Service Disconnecting the Gas Inlet and Exhaust Tubes CAUTION—Escaping Gas Gas can escape from open gas connections when the detector gas flow and/or the gas supply is turned on. The escaping gas can pose a health and safety risk. Make sure that the detector gas flow and the gas supply are turned off before you remove the nebulizer, disconnect the gas tubes or remove the gas filter assembly from the detector.
  • Page 126 • Maintenance and Service c) Wait until the system pressure is down to zero before you continue. d) Turn off the gas supply to the detector. 3. Turn off the detector with the main power switch. Follow these steps On the gas port on the detector, disconnect the elbow connectors of the gas tubes from the port.

  • Page 127: Disconnecting The Waste Line

    • Maintenance and Service Disconnecting the Waste Line Parts and tools required If no new waste line is to be installed • Seal plug for the waste outlet If the waste line is to be replaced • ♦ Replacement waste line ♦...

  • Page 128: Removing The Nebulizer

    • Maintenance and Service Removing the Nebulizer CAUTION—Sharp Tip of Nebulizer Capillary The fused-silica capillary inside the nebulizer protrudes from the nebulizer tip. The nebulizer capillary is fragile and sharp and can cause personal injury and damage to the capillary. To avoid personal injury, always wear safety glasses when handling the nebulizer.
  • Page 129 • Maintenance and Service 2. Turn off the pump flow and then the gas flow: a) Turn off the pump flow to the detector. Wait at least 5 minutes. During the waiting period, the detector drains any remaining mobile phase to waste. b) Turn off the gas flow on the detector.
  • Page 130 • Maintenance and Service 2. Pull the nebulizer straight out of the opening. Avoid the nebulizer tip from touching the sides of the nebulizer opening, as this can damage the tip. Figure 28: Removing the nebulizer 3. Install the dust seal plug to the opening for the nebulizer. 4.

  • Page 131: Replacing The Gas Filter Assembly

    • Maintenance and Service Replacing the Gas Filter Assembly CAUTION—Gas Filter Rupture upon Excessive Gas Supply Pressure An excessive supply gas pressure can lead to an overpressure in the detector and cause the gas filters to rupture. This can pose a health and safety risk.
  • Page 132 • Maintenance and Service Preparations 1. Flush the detector with the detector gas flow being turned on. For recommendations on flushing the detector, see section 7.4.2 Flushing the Detector Between Analyses, page 121. 2. Turn off the pump flow and then the gas flow: a) Turn off the pump flow to the detector.
  • Page 133 • Maintenance and Service 3. Push the protective cover upward to release it from the two bottom screws (no. 1 in Figure 31). Lift the protective cover away from the front panel (no. 2 in Figure 31). Figure 31: Removing the protective cover The gas filters are uncovered now: Figure 32: Gas filter assembly Description...
  • Page 134 • Maintenance and Service b) Pull the two elbow fittings off from the gas connectors on the detector (no. 2 in Figure 33). Figure 33: Unlocking an elbow fitting with the multitool 5. Pull the gas filter assembly out of the clamps. Figure 34: Pulling the gas filter assembly out of the clamps 6.
  • Page 135 • Maintenance and Service ♦ The top gas filter must be the HEPA gas filter (thin white inner filter cylinder; no. 1 in Figure 35). 7. Push the new gas filter assembly into the clamps observing the orientation signs for the gas flow on the gas filters. See Figure Figure 35: Correct orientation of the gas filter assembly Description...

  • Page 136: Replacing The Main Power Fuses

    • Maintenance and Service Replacing the Main Power Fuses When Blown fuses Parts required Replacement fuses (2 fuses, 3.15AT, 250 V AC, slow-blow, 5 x 20 mm) Tools required Slotted screwdriver, any size between 3.3 mm and 5.5 mm is appropriate Preparations WARNING—Electric Shock...
  • Page 137 • Maintenance and Service Description Main power switch (on/off control) Fuse holder Power-inlet connector 1. Use the screwdriver to remove the fuse holder. 2. Replace the two fuses with new fuses of the specified type and current rating. Always replace both fuses. 3.

  • Page 138: Updating The Detector Firmware

    • Maintenance and Service 7.10 Updating the Detector Firmware When Updating the detector firmware might be required, for example, when a new firmware version is released that adds functionality or solves problems of a previous version. Items required Firmware version/Chromeleon Service Release as appropriate TIP When a new firmware version is released, the new version will be included in the next available Chromeleon Service Release.
  • Page 139 • Maintenance and Service Follow these steps 1. Start the Chromeleon 7 Instrument Configuration Manager or the Chromeleon 6.8 Server Configuration program. 2. Perform a firmware update from the General tab page in the configuration dialog box for the detector. For details, refer to the Chromeleon Help.

  • Page 140: Replacing The Doors

    • Maintenance and Service 7.11 Replacing the Doors When Damage of door TIP The maintenance procedures do not require that you remove the doors. If this should ever be required for a specific reason or procedure, follow the related steps in this section. Parts required Replacement door Follow these steps...
  • Page 141 • Maintenance and Service 4. Insert the hinges in the groove, by pushing up and slightly turning the door. 5. Push the door downward to lock it in place. You can close the door only when it is properly installed. Vanquish Charged Aerosol Detectors Operating Manual Page 141...

  • Page 142: Transporting Or Shipping The Detector

    • Maintenance and Service 7.12 Transporting or Shipping the Detector If you want to transport the detector to a new location or if you need to ship the detector, first prepare the detector for transport and then move or ship the detector as required. Follow the instructions in this section. Observe the following safety guidelines: CAUTION—Heavy Load, Bulky Device The detector is too heavy or bulky for one person alone to handle safely.
  • Page 143 • Maintenance and Service 7. Install the carrying handles and remove the detector from the Vanquish system. Follow the instructions on dismounting the system stack in the Transporting or Shipping the System section of the Vanquish System Operating Manual. TIP To remove the slide-in module from the detector, follow the steps in section 7.13.1, page 145.
  • Page 144 • Maintenance and Service 2. If you need to return the detector to Thermo Fisher Scientific for depot repair, contact your local Thermo Fisher Scientific support organization for the appropriate procedure. CAUTION—Possible Contamination Hazardous substances may have contaminated the device during operation and may cause personal injury to service personnel.

  • Page 145: Slide-In Module

    • Maintenance and Service 7.13 Slide-In Module CAUTION—Damaged Gas Tubes and Compressed Gas Trying to remove the slide-in module with the gas tubes being connected to the detector can damage the gas tubes and the connectors on the detector. Using damaged gas tubes with compressed air can pose health and safety risks.
  • Page 146 • Maintenance and Service Follow these steps 1. Loosen the four captive screws on the front left and front right of the detector. Figure 38: Captive screws on the slide-in module 2. Push all tubing and capillaries, which are present in the tubing chase of the Vanquish system modules, into the tubing chase.
  • Page 147 • Maintenance and Service 4. Remove the slide-in module from the enclosure. The following steps require a team effort: a) Take the slide-in module on both sides from below. b) Pull the slide-in module from the rails towards the front. c) Place the slide-in module on a clean and stable surface.

  • Page 148: Installing The Slide-In Module

    • Maintenance and Service 7.13.2 Installing the Slide-In Module Parts required Replacement slide-in module Tools required Screwdriver, Torx T20 Preparations 1. Verify that the detector enclosure into which the slide-in module is installed is clean. If required, clean the inner and outer surfaces of the enclosure.
  • Page 149 • Maintenance and Service d) Push the slide-in module onto the rails and into the enclosure until the slide-in module sits completely in the enclosure. Figure 40: Inserting the slide-in module 4. Tighten the four captive screws on the slide-in module hand-tight. NOTICE Verify that the screws are tightened.
  • Page 150 • Maintenance and Service Page 150 Vanquish Charged Aerosol Detectors Operating Manual...

  • Page 151: Troubleshooting

    • Troubleshooting 8 Troubleshooting This chapter is a guide to troubleshooting issues that may arise during operation of the detector. Vanquish Charged Aerosol Detectors Operating Manual Page 151...

  • Page 152: General Information About Troubleshooting

    • Troubleshooting General Information about Troubleshooting The following features help you to identify and eliminate the source for problems that may arise during operation of the detector. TIP For information about operating problems that might occur during the operation of a Vanquish system, refer to the Vanquish System Operating Manual.
  • Page 153 • Troubleshooting • Chromeleon 7: The Instrument Audit Trails can be found on the ePanel Set (Audit ePanel). In addition, Audit Trails for each instrument are available in the Chromeleon 7 Console Data view, in the folder of the instrument. •...
  • Page 154 • Troubleshooting Parameters Description Charger voltage Displays the voltage applied to the corona needle to charge the (secondary) ion gas stream. Typical value ranges from 2.0 - 3.0 kV. If the value is outside of this range, contact Technical Support. Charger current Displays the current that is required to charge the (secondary) ion gas stream.

  • Page 155: Messages

    • Troubleshooting Messages The table lists the most frequently observed messages for the detector and provides troubleshooting assistance. Each message consists of two- digit or four-digit code number and a text. The code number is the unique identifier for the problem while the wording may change. If you are unable to resolve the problem following the instructions, contact Technical Support for assistance.
  • Page 156 • Troubleshooting Message and Code Description and Remedial Action Code 89 Liquid leak sensor Contact Thermo Fisher Scientific Technical Support for assistance. To missing or defective operate the detector nevertheless, you can disable the leak sensor functionality in Chromeleon by setting Leak Sensor Mode to Disabled. Code 90 Download firmware You tried to download a firmware with an earlier version number than the mismatch –...
  • Page 157 • Troubleshooting Message and Code Description and Remedial Action Code 6010 Nebulizer gas The nebulizer gas pressure has exceeded the maximum limit. pressure too high. The detector gas flow and the pump flow are automatically stopped. The drain pump remains turned on for a short period longer and is then turned off.

  • Page 158: Operating Problems

    • Troubleshooting Operating Problems This section is a guide to troubleshooting issues that may arise during operation of the Vanquish charged aerosol detector. 8.3.1 Resolving Leakage When The leak sensor is wet. The leak sensor reports leakage. Parts required Replacement part as required Additional items required Cloth or tissue Preparations...

  • Page 159: Resolving Gas Supply Overpressure

    • Troubleshooting 8.3.2 Resolving Gas Supply Overpressure CAUTION—Excessive Gas Supply Pressure An improper or excessive gas supply pressure can lead to an overpressure in detector that can cause the detector to release gas. This can pose a health and safety risk. •...

  • Page 160: Resolving Flooding In The Detector

    • Troubleshooting 3. On the gas supply, turn on the gas flow to the detector. If the gas supply pressure has fallen within the allowed range, the overpressure relief valve will remain closed. 4. Turn on the gas flow in the detector. See section 6.5.3, page 5.

  • Page 161: Additional Detector Operating Problems

    • Troubleshooting 8.3.4 Additional Detector Operating Problems This section provides additional issues that may arise during operation of the Vanquish charged aerosol detector. Locate the table for the type of symptom you have, find the possible cause, and use the description of the solution to help you solve your problem quickly.
  • Page 162 • Troubleshooting Symptom Possible Cause Remedial Action High backpressure Nebulizer Poor solubility of analyte during nebulization/analyte build-up. nozzle/capillary clogged Check the backpressure of the nebulizer: 1. Remove the nebulizer from the detector (see section 7.7, page 128). 2. Set up a direct flow connection from the pump to the nebulizer. Make sure no other module is connected in between.

  • Page 163: Specifications

    • Specifications 9 Specifications This chapter provides the physical and performance specifications, including information about the materials used in the flow path of the detector. Vanquish Charged Aerosol Detectors Operating Manual Page 163...

  • Page 164: Performance Specifications

    • Specifications Performance Specifications The detector performance is specified as follows: Type Specification Detection type Charged aerosol detection Nebulization FocusJet, concentric Pump flow rate VH-D20 0.01 – 2.0 mL/min VF-D20 0.2 – 2.0 mL/min Evaporation temperature VH-D20 Adjustable range: ambient +5 to +100 °C VF-D20 Selectable temperatures: +35 °C, +50 °C, +70 °C Signals...
  • Page 165 • Specifications Type Specification Control Chromeleon 7, Chromeleon 6.8 The detector can be operated also with other data systems. For details, contact the Thermo Fisher Scientific sales organization. Keypad with 2 buttons for performing certain functions directly from the detector Materials in the flow path Stainless steel (type 316), Nitronic®...

  • Page 166: Physical Specifications

    • Specifications Physical Specifications The physical conditions of the detector are specified as follows: Type Specification Range of use Indoor use only Ambient temperature 5 – 35 °C Ambient humidity 20 - 80% relative humidity (non-condensing) Pollution degree Power requirements 100 –...

  • Page 167: Accessories, Consumables And Replacement Parts

    • Accessories, Consumables and Replacement Parts 10 Accessories, Consumables and Replacement Parts This chapter describes the standard accessories that are shipped with the detector and the accessories that are available as an option. This chapter also provides information for reordering consumables and replacement parts.

  • Page 168: General Information

    • Accessories, Consumables and Replacement Parts 10.1 General Information The detector must be operated only with the replacement parts and additional components, options, and peripherals specifically authorized and qualified by Thermo Fisher Scientific. Accessories, consumables, and replacement parts are always maintained at the latest technical standard.

  • Page 169: Ship Kit

    • Accessories, Consumables and Replacement Parts 10.2 Ship Kit The ship kit includes the items listed in the table. The kit content is subject to change and may vary from the information in this manual. See the content list included in the kit for the most recent information about the kit content at the time when the detector is shipped.

  • Page 170: Optional Accessories

    • Accessories, Consumables and Replacement Parts 10.3 Optional Accessories Item Part No. Remarks Corona nitrogen 6295.0200 Provides on-demand, uninterrupted supply of dry nitrogen generator 1010 from a compressed air source. Corona air compressor 6295.0300 Supplies the required amount of air pressure for operation 230 V of the detector.

  • Page 171: Consumables And Replacement Parts

    • Accessories, Consumables and Replacement Parts 10.4 Consumables and Replacement Parts Capillaries, tubing and tubing tools Description Part No. Capillary, Viper, 0.13 mm I.D., 350 mm length 6040.2335 Viper union 6040.2304 Tubing cutter 70-7112 Multitool 40-0288 For system capillaries, refer to the Vanquish System Operating Manual Gas components Description Part No.
  • Page 172 • Accessories, Consumables and Replacement Parts Description Part No. System interlink cable 6036.0004 Power cords Description Part No. Power cord, Australia, China 6000.1060 Power cord, Denmark 6000.1070 Power cord, EU 6000.1000 Power cord, India, SA 6000.1090 Power cord, Italy 6000.1040 Power cord, Japan 6000.1050 Power cord, UK...

  • Page 173: Compliance Information

    • Compliance Information 11 Compliance Information This chapter provides additional information about compliance. Vanquish Charged Aerosol Detectors Operating Manual Page 173...

  • Page 174: Declarations Of Conformity

    • Compliance Information 11.1 Declarations of Conformity CE Declaration of Conformity The device has satisfied the requirements for the CE mark and is compliant with the applicable requirements. cTUVus Compliance The cTUVus label on the device indicates that the device has satisfied the requirements for the cTUVus mark.

  • Page 175: Weee Compliance

    • Compliance Information 11.2 WEEE Compliance This product is required to comply with the European Union’s Waste Electrical & Electronic Equipment (WEEE) Directive 2002/96/EC. It is marked with the following symbol: Figure 41: WEEE symbol Thermo Fisher Scientific has contracted with one or more recycling or disposal companies in each European Union (EU) Member State, and these companies should dispose of or recycle this product.

  • Page 176: Fcc Compliance

    • Compliance Information 11.3 FCC Compliance This equipment has been tested and found to comply with the limits for a Class A digital device, pursuant to part 15 of the U.S. FCC Rules. These limits are designed to provide reasonable protection against harmful interference when the equipment is operated in a commercial environment.

  • Page 177: Index

    • Index 12 Index Vanquish Charged Aerosol Detectors Operating Manual Page 177...
  • Page 178 • Index drain system ............80 drainage ..............80 accessories ............167 optional ............170 ship kit .............. 169 equilibration............93 additive evaporation temperature information ............25 actual temperature .......... 102 Audit Trail messages ..........155 control .............. 102 autozero ..............100 guidelines ............
  • Page 179 • Index gas supply ..............52 optimization gas tubes guidelines ............103 connecting ............67 parameters overview ........104 gloves ..............21 overview (functional) ..........29 guide hole ............... 71 peak width ............. 101 installation .............. 45 pH range ..............25 interior view ............
  • Page 180 • Index shutdown system equilibration ..........93 long-term ............112 System Interlink ............59 short-term ............111 signal channel ............106 background current ........100, 106 transport ............... 142 CAD_1 ............100, 106 troubleshooting ............ 151 evaporation tube temperature ....100, 106 tubing ..............73 gas regulator pressure ......100, 106 tubing bracket ............
  • Page 181 • Index Vanquish Charged Aerosol Detectors Operating Manual Page 181...
  • Page 182 www.thermofisher.com Thermo Fisher Scientific Inc. 168 Third Avenue Waltham Massachusetts 02451...

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