3
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Detector Overview
3.1
Detector Features
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The detector comprises the following main features:
•
Charged aerosol detection method for liquid chromatography for
detection of all non-volatile and many semi-volatile analytes
•
Detection based on measuring charge that is proportional to the
amount of analyte, and, for non-volatile analytes, independent of
the chemical structure of the analyte
In comparison to UV detection, a chromophore is not required for
detection, and in comparison to mass spectrometry, ionization of
the analyte is not necessary.
•
Detection with great sub-nanogram sensitivity and a wide dynamic
range
•
FocusJet™ nebulizer with concentric design for extended low pump
flow rate range
•
Adjustable evaporation temperature for optimization of analyte
response and use with a wider range of eluents
♦
VH-detector: Adjustable range for the evaporation temperature
♦
VF-detector: Selectable evaporation temperatures
•
For data collection, the detector supports the following data
acquisition rate:
♦
VH-detector: Up to 200 Hz
♦
VF-detector: Up to 100 Hz
Vanquish Charged Aerosol Detectors Operating Manual