Thermo Scientific Vanquish VF-D20 Operating Manual page 96

6 • Operation
Guidelines for Additives
Page 96
• Avoid filtering the mobile phase. Filtration can increase the amount
of detectable particulates within the mobile phase.
•
With highly combustible mobile phases, such as tetrahydrofuran
(THF) and other ethers and ketones, use nitrogen as supply gas.
•
If a particular solvent or additive causes problems due to high
residue after evaporation, try a different grade or vendor for the
solvent.
• When changing the operating mobile phase
Make sure that the solvents are miscible and that any buffer salts
will not cause precipitation. If required, use an appropriate
intermediate solvent.
TIP Keep this in mind particularly when switching pump flow from
other detectors to the Vanquish charged aerosol detector.
•
Overview of typical compatible solvents for use with the detector:
Typical compatible solvents
Water
Methanol
Isopropanol
Acetonitrile
Acetone
Methylene chloride
Hexane
Chloroform
Tetrahydrofuran
NOTE: Use with nitrogen gas only.
•
Use only volatile additives for the mobile phase, such as pH
modifiers, salts and ion pairing reagents.
•
Acetic and formic acid and their corresponding ammonium salts are
typically used to prepare volatile buffers.
Vanquish Charged Aerosol Detectors Operating Manual