Pressure Buildup - PerkinElmer 200 UV/VIS Series User Manual

Safety and Regulatory Information

Pressure Buildup

Over time, you may observe a gradual increase in the system operating pressure. If you
observe pressure readings greater than 3.45 MPa (500 psi) above the normal operating pres-
sure of your analysis, the following items may need attention:
• If you are injecting "clean" samples and there is no other apparent cause for the pressure
build-up, remove, disassemble, and clean the flowcell.
• If you are injecting "dirty" samples, the flowcell may be clogged or the column packing
material may have retained contaminated particulates. Remove and clean the flowcell,
and replace the column.
• The column end fitting or column frit may be plugged. Replace the end fitting or frit to
relieve excess pressure.
• In-line filters may be plugged. Replace the filter element.
Safety and Regulatory Information
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