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D Solvent Considerations
Properties of common solvents: (Continued)
Solvent
Isobutyl alcohol
Isopropyl alcohol
Isopropyl myristate
Methanol
Methyl t-butyl ether
Methyl ethyl ketone
Methyl isobutyl ketone
N-Methylpyrrolidone
Pentane
n-Propyl alcohol
Propylene carbonate
Pyridine
Toluene
1,2,4-Trichlorobenzene
Triethylamine
Trifluoroacetic acid
Water
o-xylene
Solvent miscibility
Before you change solvents, refer to the table below to determine solvent
miscibility. Be aware of these effects:
•
Changes involving two miscible solvents can be made directly. Changes
involving two solvents that are not totally miscible (for example, from
chloroform to water) require an intermediate solvent like n-propanol.
•
When you switch from a strong buffer to an organic solvent, thoroughly
flush the system using water before you add the organic solvent (see
"Water" on page
88
July 7, 2014, 715003736IVD Rev. C
Vapor Pressure
mm Hg (Torr)
8.8 at 20 °C
32.4 at 20 °C
<1 at 20 °C
97 at 20 °C
240 at 20 °C
74 at 20 °C
16 at 20 °C
0.33 at 25 °C
420 at 20 °C
15 at 20 °C
0.13 at 20 °C
18 at 25 °C
28.5 at 20 °C
1 at 20 °C
57 at 25 °C
97.5 at 20 °C
17.54 at 20 °C
6 at 20 °C
82).
Boiling
Flash
Point (°C)
Point (°C)
107.7
28
82.26
12
192.6
164
64.7
11
55.2
-28
79.64
-9
117.4
18
202.0
86
36.07
-49
97.2
23
241.7
135
115.25
20
110.62
4
213.5
106
89.5
-9
71.8
-3
100.0
144.41
17
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