Preventing Leaks - Waters ACQUITY UPLC I-Class IVD System Manual

The Load Ahead and Loop Offline options of the ACQUITY UPLC I-Class IVD
SM-FTN help decrease cycle time. See the ACQUITY UPLC Console online
Help for details on how to use these features.
Caution:
does not operate for the first injection of a sample set or for injection sets
whose methods differ.
Consider these attributes of the Load Ahead option carefully before deciding
to use it:
• Load Ahead is designed for two consecutive samples whose conditions,
as specified in their respective methods, are identical. If you run
consecutive samples for which different methods are specified, the first
method will be applied to all samples aspirated.
• MassLynx software does not operate in Load Ahead mode across
batches.

Preventing leaks

Preventing leaks ensures that the system maintains adequate pressure and
sample integrity throughout the analysis.
Leaks can potentially occur at any tubing connection, gasket, or seal but are
most common at tubing connections. Low pressure leaks (on the intake side of
the solvent manager's pump) cause solvent loss and air introduction during
the intake cycle. Leaks at high pressure fittings (downstream of the i
can leak solvent but do not introduce air.
To prevent leaks, follow Waters' recommendations for the proper tightening of
system fittings. Note specifically that different techniques apply to
retightening fittings versus installing them for the first time.
See also:
• The user documentation for the modules included in your system for
more details on leak detection.
• The ACQUITY UPLC I-Class IVD Column Heater Overview and
Maintenance Guide (part number 715003738) for details on connecting
active preheaters.
To prevent the loss of sample, note that the Load Ahead option
July 7, 2014, 715003736IVD Rev. C

Preventing leaks

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