Waters ACQUITY UPLC I-Class IVD System Manual page 40

4 Maintenance Procedures
Column Manager maintenance procedures:
Maintenance
procedure
Replace the leak
sensor on the column
heater
Replace the column
Replace the active
preheater assembly
Replace the column
stabilizer assembly
40 July 7, 2014, 715003736IVD Rev. C
Frequency
As needed. For example, when the leak sensor is
damaged or an error message states the leak sensor
is not detected.
As needed. The typical failure modes are as follows:
• High backpressure. The column causes a high
pressure shutdown.
• Method requirements are not attained. This can
be exhibited by poor peak shape, resolution
between peaks lost, tailing, etc. Perform a plate
count to establish column efficiency.
As needed. The typical failure modes are as follows:
• Error message. Any active preheater error
messages, including messages indicating the
active preheater is not detected or connected or
has a temperature sensor error.
• Leak. This can be detected visibly, using the leak
sensor or by noticing that peak retention times
vary.
• Carryover. Reseat the active preheater assembly
connections and/or replace the ferrules.
• Split peaks. Reseat the active preheater
assembly connections and/or replace the
ferrules.
As needed. The typical failure modes are as follows:
• Leak. This can be detected visibly, using the leak
sensor or by noticing the peak retention times
vary.
• Carryover. Reseat the column stabilizer
assembly connections and/or replace the
ferrules.
• Split peaks. Reseat the column stabilizer
assembly connections and/or replace the
ferrules.