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Waters ACQUITY UPLC I-Class IVD Overview And Maintenance Manual

Column heater
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ACQUITY UPLC
I-Class IVD
Column Heater
Overview and Maintenance Guide
715003738IVD / Revision C
Copyright © Waters Corporation 2019
All rights reserved

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Summary of Contents for Waters ACQUITY UPLC I-Class IVD

  • Page 1 ACQUITY UPLC I-Class IVD Column Heater Overview and Maintenance Guide 715003738IVD / Revision C Copyright © Waters Corporation 2019 All rights reserved...
  • Page 2 Rev. C, 715003738IVD...

  • Page 3: General Information

    Other registered trademarks or trademarks are the sole property of their owners. Contacting Waters Contact Waters™ with technical questions regarding the use, transportation, removal, or disposal of any Waters product. You can reach us via the Internet, telephone, or conventional mail. Waters contact information: Contacting medium...

  • Page 4: Safety Considerations

    34 Maple Street Milford, MA 01757 Safety considerations Some reagents and samples used with Waters instruments and devices can pose chemical, biological, or radiological hazards (or any combination thereof). You must know the potentially hazardous effects of all substances you work with.

  • Page 5: Considerations Specific To The Column Heater

    To avoid electric shock, do not remove the device’s protective Warning: panels. The components within are not user-serviceable. Relocation To avoid injury, if the ACQUITY UPLC I-Class IVD system Warning: must be relocated, drain and remove all liquids, including solvents and waste, from the system.

  • Page 6: Safety Hazard Symbol Notice

    Safety hazard symbol notice Documentation needs to be consulted in all cases where the symbol is used to find out the nature of the potential hazard and any actions that have to be taken. Equipment misuse notice If the equipment is used in a manner not specified by the manufacturer, the protection provided by the equipment may be impaired.
  • Page 7 For compliance with the Waste Electrical and Electronic Equipment Directive (WEEE) 2012/19/EU, contact Waters Corporation for the correct disposal and recycling instructions. For indoor use only. No pushing. Serial number.

  • Page 8: Audience And Purpose

    ACQUITY UPLC I-Class IVD column heaters. Intended use of the column heater Waters designed the ACQUITY UPLC I-Class IVD column heater for use with the ACQUITY UPLC I-Class IVD system to perform ultra-performance liquid chromatography for in vitro diagnostic use.

  • Page 9: Ism Classification

    • Whenever possible, verify method accuracy and precision using matrix-matched calibrators and QC samples. • Use one or more internal standard compounds, preferably isotopically labeled analytes. ISM classification ISM Classification: ISM Group 1 Class B This classification has been assigned in accordance with IEC CISPR 11 Industrial Scientific and Medical (ISM) instruments requirements.

  • Page 10: Manufacturing Information

    Manufacturing information Waters Corporation 34 Maple Street Milford, MA 01757 Australian sponsor information Australian Sponsor Emergo, Australia Level 20, Tower II Darling Park 201 Sussex Street Sydney, NSW 2000 Australia Rev. C, 715003738IVD...

  • Page 11: Table Of Contents

    Table of Contents General Information ..................iii Copyright notice ....................iii Trademarks ......................iii Contacting Waters ....................iii Safety considerations ..................iv Considerations specific to the column heater............. v High voltage hazard ..................v Relocation ......................v FCC radiation emissions notice ................v Canada spectrum management emissions notice ..........
  • Page 12 4 Maintenance Procedures ..............57 Maintenance schedule ..................58 Spare parts ......................61 Safety and handling ..................61 Contacting Waters Technical Service ............61 Locating system serial numbers ............... 62 Configuring maintenance warnings .............. 63 Replacing the column heater’s leak sensor ..........63 Required materials ..................
  • Page 13 Biologically hazardous materials warning ..........83 Biologically hazardous materials and chemical hazard warning ....84 Caution advisory ....................84 Warnings that apply to all Waters instruments and devices ....85 Warnings that address the replacing of fuses ..........90 Electrical and handling symbols ..............92 Electrical symbols ....................
  • Page 14 Electrical specifications ................... 96 Performance specifications ................97 Wetted materials of construction ..............98 September, 2019, 715003738IVD Rev. C...

  • Page 15: Overview

    Major components ................17 Column heater description A standard component of the basic ACQUITY UPLC I-Class IVD system, the column heater heats the column compartment to any temperature, from 20ºC to 90 ºC, that is at least 5 ºC above the ambient temperature. For example, if the ambient temperature is 25 ºC, the range is 30 to 90 ºC.

  • Page 16: Active Preheater

    1 Overview A receptacle on the column heater’s right-hand side receives the column’s eCord™ chip. The eCord column chip stores column manufacturing and usage data, which you can access from the ACQUITY UPLC Console. The column heater does not have its own power supply; it draws power from the sample manager.

  • Page 17: Major Components

    Major components Major components The following diagram shows the column heater’s major components: Location of Column compartment tray Active preheater column assembly Active preheater Fitting retainer Column heater components: Component Description Column Contains the column, column heater, in-line filter, and compartment active preheater or column stabilizer assembly.
  • Page 18 1 Overview Column heater components: (Continued) Component Description Column stabilizer Passively heats the incoming solvent before the solvent (optional) enters the column. Originally used in the ACQUITY UPLC system, the column stabilizer can be useful when you transfer methods from that system. Drip tray Captures any leakage from the column or column connections and routes it into the drip management...

  • Page 19: Preparing The Column Heater

    Installation recommendations for fittings Preparing the column heater Contents: Topic Page Installation recommendations for fittings ........19 Installing the column heater ............22 Installing the optional in-line filter ..........41 Installing the column............... 44 Installation recommendations for fittings To avoid personal contamination with biologically Warning: hazardous materials, toxic compounds, or their residues, wear clean, chemical-resistant, powder-free gloves when reinstalling...
  • Page 20 When tightening system fittings, consult the following table: Installation recommendations for ACQUITY UPLC I-Class IVD column compartment fittings: Fitting Recommended tightening...
  • Page 21 Installation recommendations for fittings Installation recommendations for ACQUITY UPLC I-Class IVD column compartment fittings: (Continued) Fitting Recommended tightening Stainless steel (gold-plated) fitting with Finger-tight, plus 3/4-turn long flats and 2-piece stainless steel using wrench ferrule 3/4-turn TP03378 Long flats 2-piece ferrule...

  • Page 22: Installing The Column Heater

    Installing the MS extension bracket Use the MS-bracket to position the column heater to the right of the ACQUITY UPLC I-Class IVD system stack. Doing so reduces the length of the tubing that extends to the mass spectrometer’s inlet. September, 2019, 715003738IVD Rev. C...

  • Page 23: Required Materials

    Installing the column heater Process for installing the MS-bracket Task Remove the column heater from the device chassis page 24 Install the MS-bracket on the column heater chassis page 25 Attach the column heater housing onto the MS-bracket page 29 Install the column heater and connecting accessories, such as page 30 the MS drip tray, leak sensor, and drain tubing...
  • Page 24 2 Preparing the column heater MS-bracket kit major components: Column heater housing TP03252 Hinge MS-bracket MS drip tray To avoid burn injuries, set the column temperature to Off, and Warning: then allow the column compartment and its components to cool for 60 minutes before touching them.
  • Page 25 Installing the column heater Using the 1/4-inch open-end wrench, disconnect the column inlet, active preheater, or column stabilizer tubing from injector port 6 of the sample manager. Column inlet, active preheater, or column stabilizer tubing Disconnect the column-outlet PEEK tubing from the MS inlet. Open the column heater door.
  • Page 26 2 Preparing the column heater Remove the TORX screw from the right-hand side of the column heater, just behind the eCord receptacle. TORX screw eCord receptacle Remove the column heater chassis by gently pulling it toward you with your left hand while releasing the lock with your right hand. Remove the 25-pin cable from the receptacle on the back of the column heater.
  • Page 27 Installing the column heater Set the column heater aside. Ensure that the front left-hand foot of the column heater’s rear enclosure locks into the retainer bracket on the sample manager below If the retainer bracket is not installed on the sample Alternative: manager chassis, perform these tasks: To avoid injuries arising from solvent spills, remove the...
  • Page 28 2 Preparing the column heater Install the column heater’s rear enclosure by sliding its front, left-hand foot into the retainer bracket on the chassis. Install the Phillips screw that secures the column heater’s rear enclosure to the chassis. Replace any other instruments and the solvent tray above the column heater’s rear enclosure.
  • Page 29 Installing the column heater Install the TORX screw in the tab and tighten it slightly. Hold the left-hand side of the bracket into the slot and guide the MS-bracket tab on the right-hand side into the cutout in the chassis. Ensure that the 25-pin cable remains in the slot as Requirement: you guide the tab into the cutout.
  • Page 30 2 Preparing the column heater Swing the column heater housing to align it with the front of the mass spectrometer and ensure that the column heater is at the correct height for the mass spectrometer inlet. If the column heater housing height is not correct for the mass spectrometer inlet, perform these tasks: Remove the two TORX screws that secure the hinge to the MS-bracket.
  • Page 31 Installing the column heater Install the leak sensor (optional): Align the leak sensor’s T-bar with the slot in the left-hand side of the MS-bracket drip tray and slide the leak sensor into place. Leak sensor T-bar TP02892 Slot Route the leak sensor cable through the slot in the column heater housing.
  • Page 32 2 Preparing the column heater Tighten the cable clamp nut with the 4-mm wrench. 25-pin cable routed through slot 4-mm cable clamp nut on stud Cable clamp Install the column heater in its housing: Insert the tab on the left-hand side of the column heater into the slot on the left-hand side of the housing.
  • Page 33 Installing the column heater Push the 25-pin cable into the socket on the back of the column heater, and then tighten the thumbscrews to secure the cable to the socket. Thumbscrews If you installed the optional leak sensor, plug the connector into the receptacle located behind the column heater.
  • Page 34 2 Preparing the column heater 10. Slide the column compartment tray to the right. Column compartment tray 11. If desired, install the active preheater assembly: Gently compress the active preheater assembly retainer between your thumb and forefinger and push it into the left-hand side of the column compartment until it snaps into place.
  • Page 35 Installing the column heater Set the column into the column compartment. Ensure that the stainless steel tubing from the sample Requirement: manager is routed through the front notch on the lower left-hand side of the column compartment and that the PEEK tubing to the mass spectrometer inlet is routed through the groove on the right-hand side of the column compartment.

  • Page 36: Installing The Optional Column Stabilizer Assembly

    2 Preparing the column heater Attach the eCord fob to the receptacle on the side of the column heater. Receptacle eCord fob Close the column heater door. Installing the optional column stabilizer assembly The column heater’s optional column stabilizer reduces sensitivity to ambient temperature swings by transferring heat (via conduction) from the column heater’s film element through the thermal gasket to the column inlet tubing.
  • Page 37 The column stabilizer’s passive design lends itself to lower flow rate and higher volume applications. If you are running an HPLC or UPLC method that was originally developed for use with a column stabilizer, Waters recommends that you continue to use the column stabilizer when you run that method on the ACQUITY UPLC I-Class IVD system.

  • Page 38: Required Materials

    2 Preparing the column heater Required materials • Clean, powder-free, chemical-resistant gloves • 50/100-mm or 150-mm column stabilizer kit: – Collet and compression screw multi-tool (collet separator) – Column stabilizer assembly – PEEK tubing for connecting the column to the MS flow cell –...
  • Page 39 Installing the column heater Remove the active preheater assembly from the retainer in the column compartment. Active preheater assembly Using the needle-nose pliers, gently compress the top and bottom of the active preheater retainer and pull it out of the column compartment. Gently compress retainer here Remove the clear, protective backing from the thermal gasket and, with...
  • Page 40 2 Preparing the column heater Press the thermal gasket into the column compartment tray, ensuring that the gasket is centered and formed into the bottom of the tray, with equal lengths on both sides. Firmly press the column stabilizer assembly into the thermal gasket, ensuring that the thermal gasket uniformly envelops the sides of the column stabilizer and does not bunch beneath it.

  • Page 41: Installing The Optional In-Line Filter

    Installing the optional in-line filter Carefully route the column-stabilizer-inlet tubing through the groove on the side of the tray. To avoid stripping the threads, do not overtighten Caution: screws. 10. Insert the Phillips screws into the threaded holes and tighten them gently using the Phillips screwdriver.

  • Page 42: Required Materials

    2 Preparing the column heater To avoid burn injuries, set the column temperature to Off, and Warning: then allow the column compartment and its components to cool for 60 minutes before touching them. Monitor the column compartment internal temperature to ensure that all components are cool. To prevent contaminating system components, wear clean, Caution: chemical-resistant, powder-free gloves when installing the optional...
  • Page 43 Installing the optional in-line filter Reusable fitting Ferrule Outlet tubing 3 mm Collet Older, reusable fittings do not have holes in their sides. Remove the column in-line filter unit from its packaging, and then push the outlet end of the active preheater or column stabilizer tubing assembly into the in-line filter inlet until it stops.

  • Page 44: Installing The Column

    2 Preparing the column heater Installing the column To avoid burn injuries, set the column temperature to Off, and Warning: then allow the column compartment and its components to cool for 60 minutes before touching them. Monitor the column compartment internal temperature to ensure that all components are cool.
  • Page 45 Installing the column To avoid damaging the tubing, use only your fingers to Caution: tighten the fittings. Holding the finger-tight reusable fitting in place, rotate the column onto the fitting until it is snug, and then tighten it up to an additional 1/6-turn.
  • Page 46 2 Preparing the column heater To connect the PEEK tubing to the MS: Remove the protective cover from the PEEK tubing from the flow cell inlet in the MS. Ensure that the label on the flow cell inlet tubing matches the type of MS and flow cell in your system.
  • Page 47 Installing the column Attach the eCord fob to the receptacle on the right-hand side of the device. Heater compartment receptacle eCord fob Close the column compartment door, and then inspect the seal around the front panel to ensure that it aligns correctly. Proper alignment of the seal is critical for a stable thermal Note: environment.
  • Page 48 2 Preparing the column heater September, 2019, 715003738IVD Rev. C...

  • Page 49: Using The Column Heater

    Resolving column heater leak sensor errors Using the column heater Contents: Topic Page Resolving column heater leak sensor errors........49 To avoid explosion, do not use the column heater with Warning: solvents whose autoignition temperatures are below 150 C. To avoid breathing harmful fumes or vapors, when using Warning: hazardous solvents, run the system in a hooded environment that provides a sufficient air exchange rate.

  • Page 50: Required Materials

    3 Using the column heater To avoid personal contamination with biologically Warning: hazardous materials, toxic compounds, or their residues, wear clean, chemical-resistant, powder-free gloves. To avoid scratching or damaging the leak sensor: Caution: • Do not allow buffered solvents to accumulate and dry on it; •...
  • Page 51 Resolving column heater leak sensor errors Disconnect the column inlet, active preheater, or column stabilizer tubing from injector port 6 of the sample manager. Location of column, active preheater, or column-stabilizer-inlet tubing Disconnect the column-outlet PEEK tubing from the detector inlet. Remove any solvent tubing routed behind the column heater door.
  • Page 52 3 Using the column heater Remove the column heater chassis by gently pulling it toward you with your left hand while releasing the lock with your right hand. To avoid damaging the leak sensor, do not grasp it by the Caution: ribbon cable.
  • Page 53 Resolving column heater leak sensor errors 11. Use a nonabrasive, lint-free wipe to dry the leak sensor prism. Prism Lint-free wipe TP02891 12. Roll up a nonabrasive, lint-free wipe and use it to absorb the liquid from the leak sensor reservoir and its surrounding area. Leak sensor reservoir Rolled-up...
  • Page 54 3 Using the column heater 13. With a cotton swab, absorb any remaining liquid from the corners of the leak sensor reservoir and its surrounding area. Leak sensor reservoir Cotton swab 14. Align the leak sensor’s T-bar with the slot in the side of the leak sensor reservoir and slide the leak sensor into place.
  • Page 55 Resolving column heater leak sensor errors 15. If you detached the connector from the front of the instrument, reattach it and power-on the sample manager. 16. In the ACQUITY UPLC Console, select Sample Manager – FTN from the system tree. 17.
  • Page 56 3 Using the column heater September, 2019, 715003738IVD Rev. C...

  • Page 57: Maintenance Procedures

    Maintenance schedule ..............58 Spare parts ..................61 Safety and handling ................. 61 Safety and handling ................. 61 Contacting Waters Technical Service ..........61 Configuring maintenance warnings..........63 Replacing the column heater’s leak sensor........63 Replacing the column............... 69 Replacing the active preheater assembly ........70 Replacing the column stabilizer assembly........

  • Page 58: Maintenance Schedule

    4 Maintenance Procedures Maintenance schedule Perform the following routine maintenance on the column heater to ensure reliable operation and accurate results. When using the system throughout the day (and on nights and weekends), or when using aggressive solvents, such as buffers, perform the maintenance tasks more frequently. For information about scheduling routine preventative maintenance based on system usage, see page...
  • Page 59 Maintenance schedule Recommended routine maintenance schedule: (Continued) Maintenance Frequency procedure information Replace the As needed. The typical failure modes are as page active follows: preheater • Error message. Any active preheater assembly error messages, including messages indicating that the active preheater is not detected or connected or has a temperature sensor error.
  • Page 60 4 Maintenance Procedures Recommended routine maintenance schedule: (Continued) Maintenance Frequency procedure information Replace the Replace as part of the annual scheduled page column in-line routine maintenance and, thereafter, as filter frit needed. The typical failure modes are as follows: • High back pressure. The column in-line filter causes a high-pressure shutdown.

  • Page 61: Spare Parts

    Contacting Waters Technical Service If you are located in the USA or Canada, report malfunctions or other problems to Waters Technical Service (800 252-4752). From elsewhere, phone the Waters corporate headquarters in Milford, Massachusetts (USA) or contact your local Waters subsidiary. The Waters website includes phone numbers and email addresses for Waters locations worldwide.

  • Page 62: Locating System Serial Numbers

    4 Maintenance Procedures When you contact Waters, be prepared to provide this information: • Error message (if any) • Nature of the symptom • Serial number of the system module and its firmware version, if applicable • Flow rate •...

  • Page 63: Configuring Maintenance Warnings

    Configuring maintenance warnings Alternatives: • From the main window, place the cursor over the visual representation of the system module for which you want to view information. • Obtain the serial number from the printed labels affixed to the rear panels of system modules or inside their front doors.
  • Page 64 4 Maintenance Procedures To remove the column heater’s leak sensor: Power-off the sample manager. Disconnect the column inlet, active preheater, or column stabilizer tubing from injector port 6 of the sample manager. Location of column, active preheater, or column-stabilizer- inlet tubing Open the sample manager door, gently pulling its right-hand edge toward you.
  • Page 65 Replacing the column heater’s leak sensor Remove the TORX screw from the right-hand side of the column heater, just behind the eCord receptacle. TORX screw eCord receptacle Remove the column heater chassis by gently pulling it toward you with your left hand while releasing the lock with your right hand. September, 2019, 715003738IVD Rev.
  • Page 66 4 Maintenance Procedures To avoid damaging the leak sensor, do not grasp it by the Caution: ribbon cable. Remove the leak sensor from its reservoir, grasping it by its serrations, and pull upward on it, tilting it to the left. Serrations To install a new leak sensor: Unpack the new leak sensor.
  • Page 67 Replacing the column heater’s leak sensor Align the leak sensor’s T-bar with the slot in the side of the leak sensor reservoir and slide the leak sensor into place. TP02892 T-bar TP02909 Slot in leak sensor reservoir Leak sensor installed in reservoir Plug the leak sensor connector into the front of the instrument.
  • Page 68 4 Maintenance Procedures Hold the left-hand side of the column heater into the slot and guide the eCord receptacle tab on the right-hand side into the cutout in the instrument chassis. Cutout Install and tighten the TORX screw located behind the eCord receptacle. Connect the column inlet, active preheater, or column stabilizer tubing to injector port 6 of the sample manager.

  • Page 69: Replacing The Column

    Replacing the column Replacing the column To prevent burn injuries, set the column temperature to Off, Warning: and then allow the column compartment and its components to cool for 60 min before touching them. Monitor the column compartment internal temperature to ensure that all components are cool. To prevent contaminating system components, wear clean, Caution: chemical-resistant, powder-free gloves when replacing the column.

  • Page 70: Replacing The Active Preheater Assembly

    4 Maintenance Procedures While holding the gold active preheater fitting, rotate the column off the fitting. If you are installing the active preheater in a system Requirement: with pressures exceeding 103,421 kPa (1034 bar, 15,000 psi), use the 1/4-inch and 5/16-inch open-end wrenches to disconnect the compression fitting that attaches the active preheater assembly to the optional in-line filter or to the column.

  • Page 71: Required Materials

    Replacing the active preheater assembly To avoid burn injuries, set the column temperature to Off, and Warning: then allow the column compartment and its components to cool for 60 min before touching them. Monitor the column compartment’s internal temperature to ensure that all components are cool. To prevent contaminating system components, wear clean, Caution: chemical-resistant, powder-free gloves when replacing the active...
  • Page 72 4 Maintenance Procedures Remove the active preheater assembly from the retainer. Retainer Active preheater assembly While holding the column, disconnect the column outlet tubing. While holding the gold active preheater fitting, rotate the column off the fitting. If you are installing the active preheater in a system with Requirement: pressures exceeding 103,421 kPa (1034 bar, 15,000 psi), use the 1/4-inch and 5/16-inch open-end wrenches to disconnect the compression fitting...

  • Page 73: Replacing The Column Stabilizer Assembly

    Replacing the column stabilizer assembly manager door to the injector. Do not route the tubing behind the sample manager door hinge. Note: Do not route the tubing behind the sample manager door hinge. Active preheater inlet tubing Remove the O-ring retainer from the inlet end of the active preheater assembly tubing, and then connect the inlet tubing to port 6 of the sample manager injection valve.

  • Page 74: Required Materials

    4 Maintenance Procedures Required materials • Clean, powder-free, chemical-resistant gloves • Replacement column stabilizer assembly Required tools • 1/4-inch open-end wrench • 5/16-inch open-end wrench • Phillips screwdriver To remove the column stabilizer assembly: Stop any currently running mobile phase. Disconnect the inlet tubing from injector port 6 of the sample manager.
  • Page 75 Replacing the column stabilizer assembly To insert a new column stabilizer assembly: Firmly press the replacement column stabilizer assembly into the thermal gasket. Ensure that the thermal gasket uniformly envelops the sides of the column stabilizer and does not bunch beneath it. Thermal gasket visible along both sides of stabilizer Column-stabilizer-...
  • Page 76 4 Maintenance Procedures Carefully route the column-stabilizer-inlet tubing through the groove on the side of the column compartment. To avoid stripping threads, do not overtighten screws. Caution: Insert the Phillips screws into the threaded holes and tighten them gently using the Phillips screwdriver. Route the column-stabilizer-inlet tubing through the cutout in the top of the sample manager door to the injector.

  • Page 77: Replacing The Frit In The In-Line Filter Unit

    Replacing the frit in the in-line filter unit Replacing the frit in the in-line filter unit If your system is fitted with the optional in-line filter frit, follow the instructions below to replace the frit. To avoid burn injuries, set the column temperature to Off, and Warning: then allow the column compartment and its components to cool for 60 minutes before touching them.
  • Page 78 4 Maintenance Procedures Remove the column components (column, in-line filter unit, and active preheater or stabilizer tubing assembly). Column components: Flow Active preheater or column In-line filter unit Column stabilizer tubing assembly Inlet TP02873 Reusable fitting Detach the active preheater or column stabilizer tubing assembly from the column in-line filter unit.

  • Page 79: Cleaning The Instrument's Exterior

    Cleaning the instrument’s exterior Insert a new frit, and then reassemble the in-line filter unit using the wrenches. Reattach the active preheater or column stabilizer tubing assembly to the in-line filter unit. Start the mobile phase, examine the assembled components for leaks, and tighten fittings as needed.
  • Page 80 4 Maintenance Procedures September, 2019, 715003738IVD Rev. C...

  • Page 81: A Safety Advisories

    Warning symbols alert you to the risk of death, injury, or seriously adverse physiological reactions associated with an instrument’s use or misuse. Heed all warnings when you install, repair, or operate any Waters instrument or device. Waters accepts no liability in cases of injury or property damage resulting from the failure of individuals to comply with any safety precaution when installing, repairing, or operating any of its instruments or devices.
  • Page 82 A Safety Advisories The following symbols warn of risks that can arise when you operate or maintain a Waters instrument or device, or a component of an instrument or device. When one of these symbols appear in a manual’s narrative sections or procedures, an accompanying statement identifies the applicable risk and explains how to avoid it.

  • Page 83: Specific Warnings

    Biologically hazardous materials warning The following warning applies to Waters instruments and devices that can process biologically hazardous materials, which are substances that contain biological agents capable of producing harmful effects in humans.

  • Page 84: Biologically Hazardous Materials And Chemical Hazard Warning

    A Safety Advisories Biologically hazardous materials and chemical hazard warning This warning applies to Waters instruments and devices that can process biologically hazardous, corrosive, or toxic materials. To avoid personal contamination with biologically Warning: hazardous, toxic, or corrosive materials, you must understand the hazards associated with their handling.

  • Page 85: Warnings That Apply To All Waters Instruments And Devices

    Warnings that apply to all Waters instruments and devices Warnings that apply to all Waters instruments and devices When operating this device, follow standard quality-control procedures and the equipment guidelines in this section. Changes or modifications to this unit not expressly approved by the Attention: party responsible for compliance could void the user’s authority to operate the...
  • Page 86 A Safety Advisories Use caution when working with any polymer tubing under pressure: Warning: • Always wear eye protection when near pressurized polymer tubing. • Extinguish all nearby flames. • Do not use tubing that has been severely stressed or kinked. •...
  • Page 87 Warnings that apply to all Waters instruments and devices fare attenzione quando si utilizzano tubi in materiale polimerico Attenzione: sotto pressione: • Indossare sempre occhiali da lavoro protettivi nei pressi di tubi di polimero pressurizzati. • Spegnere tutte le fiamme vive nell'ambiente circostante.
  • Page 88 A Safety Advisories 警告：当有压力的情况下使用管线时，小心注意以下几点： • 当接近有压力的聚合物管线时一定要戴防护眼镜。 • 熄灭附近所有的火焰。 • 不要使用已经被压瘪或严重弯曲的管线。 • 不要在非金属管线中使用四氢呋喃或浓硝酸或浓硫酸。 • 要了解使用二氯甲烷及二甲基亚枫会导致非金属管线膨胀，大大降低管线的耐压能力。 경고: 가압 폴리머 튜브로 작업할 경우에는 주의하십시오. • 가압 폴리머 튜브 근처에서는 항상 보호 안경을 착용하십시오. • 근처의 화기를 모두 끄십시오. • 심하게 변형되거나 꼬인 튜브는 사용하지 마십시오. •...
  • Page 89 Warnings that apply to all Waters instruments and devices The user shall be made aware that if the equipment is used in a Warning: manner not specified by the manufacturer, the protection provided by the equipment may be impaired. L’utilisateur doit être informé que si le matériel est utilisé d’une Attention: façon non spécifiée par le fabricant, la protection assurée par le matériel risque...

  • Page 90: Warnings That Address The Replacing Of Fuses

    A Safety Advisories Warnings that address the replacing of fuses The following warnings pertain to instruments equipped with user-replaceable fuses. If the fuse types and ratings appear on the instrument: To protect against fire, replace fuses with those of the type Warning: and rating printed on panels adjacent to instrument fuse covers.
  • Page 91 Warnings that address the replacing of fuses If the fuse types and ratings do not appear on the instrument: To protect against fire, replace fuses with those of the type Warning: and rating indicated in the “Replacing fuses” section of the Maintenance Procedures chapter.

  • Page 92: Electrical And Handling Symbols

    A Safety Advisories Electrical and handling symbols Electrical symbols The following electrical symbols and their associated statements can appear in instrument manuals and on an instrument’s front or rear panels. Electrical power on Electrical power off Standby Direct current Alternating current (single phase) Protective earth terminal Frame or chassis ground Fuse...

  • Page 93: Handling Symbols

    Electrical and handling symbols Handling symbols The following handling symbols and their associated statements can appear on labels affixed to the packaging in which instruments, devices, and component parts are shipped. Keep upright! Keep dry! Fragile! Use no hooks! September, 2019, 715003738IVD Rev. C...
  • Page 94 A Safety Advisories September, 2019, 715003738IVD Rev. C...

  • Page 95: B Specifications

    Specifications The specifications presented here depend on the conditions in individual laboratories. Refer to the ACQUITY UPLC I-Class (IVD) System Site Preparation Guide (715003724), or contact the Waters Technical Service organization for additional information about specifications. Contents: Topic Page Physical specifications ..............95 Environmental specifications ............

  • Page 96: Environmental Specifications

    B Specifications Environmental specifications The following table lists the environmental specifications for the ACQUITY UPLC I-Class IVD column heater: Environmental specifications: Attribute Specification Operating temperature 4 to 40 C (39.2 to 104 F) Operating humidity 20% to 80%, noncondensing Transportation and storage temperature 30 to 60 C (22 to 140 F) Transportation and storage humidity 20 to 85%, noncondensing Electrical specifications...

  • Page 97: Performance Specifications

    Performance specifications Performance specifications The following table lists the performance specifications for the ACQUITY UPLC I-Class IVD column heater: Performance specifications: Item Specification Column capacity Single column, up to 4.6 mm internal diameter (ID), up to 150 mm in length with filter or guard column.

  • Page 98: Wetted Materials Of Construction

    • Passive preheating (also recommended in CH-A only for legacy method support) Wetted materials of construction The following table lists the wetted materials of construction for the ACQUITY UPLC I-Class IVD column heater: Wetted materials of construction: Description Specification Wetted materials 316L stainless steel September, 2019, 715003738IVD Rev.

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