System Recommendations; Acquity Uplc I-Class Ivd System Recommendations; Binary Solvent Manager Recommendations - Waters ACQUITY UPLC I-Class IVD System Manual

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D Solvent Considerations

System recommendations

ACQUITY UPLC I-Class IVD system recommendations

Caution:
system filters and capillary lines, add a small amount (less than 10%) of
an organic solvent, such as acetonitrile or methanol, and completely
replace the mobile phase daily. Aqueous solvents must not remain in a
shut-down system because they serve as a substrate for microbial
growth.
Contact Waters for recommended system cleaning and flushing
procedures.
Contact your Waters sales representative or local technical support
organization to determine the typical chromatography conditions and/or
instrument operating parameters suitable for the ACQUITY I-Class
IVD system.
Chloroform, methylene chloride, halogenated solvents, and toluene can
be used in weak dilutions (less than 10% vol.) as additives, modifiers, or
sample diluents.
Methanesulfonic acid is not recommended for use in ACQUITY UPLC
I-Class IVD systems.
Always use properly cleaned and maintained glassware.

Binary solvent manager recommendations

The seal wash system must never run dry, particularly during
separations that use a polar mobile phase.
For reversed-phase applications, use aqueous seal wash solutions with a
weak organic component (for example 1:9 methanol/water).
Do not use nonvolatile buffers as seal wash solvents.
Ensure that the mobile phase is completely soluble in and compatible
with all of the solvents in use on the system.
86
July 7, 2014, 715003736IVD Rev. C
To prevent the proliferation of microbial colonies that clog

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