Solvent And Additive Information - Thermo Scientific Vanquish VH-P10 Operating Manual

2 • Safety
2.4

Solvent and Additive Information

Page 28
To protect optimal functionality of the Vanquish system, observe these
recommendations on the use of solvents and additives:
•
The system must be used with reversed-phase (RP) compatible
solvents and additives only.
•
Use only solvents and additives that are compatible with all parts in
the flow path.
For details about the materials that are used in the flow path of the
pump, see the Specifications chapter. For information about the
materials that are used in the flow path of the other modules in the
Vanquish system, refer to the Specifications chapter in the
Operating Manual for the module.
Observe the general guidelines and recommendations on the use of
solvents and additives in the chromatography system (see
section 6.5, page 87).
•
Allowed ranges and concentrations (standard system configuration):
♦
pH range: 2-12
♦
Chloride concentration: 1 mol/L or less
• Observe the following:
♦
pH values higher than 9.5 with optical detectors
Avoid using mobile phases with a pH value higher than 9.5
together with optical detectors. This can impair the functionality
and optical performance of the detector flow cell.
♦
pH values of 2 or less or high chloride concentration
With pH values of 2 or less or high chloride concentration, the
application time should be as short as possible. Flush the system
thoroughly after these applications.
♦ Mobile phases containing ammonium hydroxide
In rare cases, a shortened lifetime of reversed-phase (UHMW-
PE) piston seals has been observed with high pH, ammonium
hydroxide containing mobile phases and prolonged exposure.
Vanquish Pumps (VH-P10) Operating Manual